21 papers · ranked by Valyu relevance
Kylan Szeto, Sarah J. Reinholt, Fabiana M. Duarte, John M. Pagano + 4 more
'Abdullah Ozer' 'Li Yao' 'John T. Lis' 'Harold G. Craighead'] We describe a versatile 96-well microplate-based device that utilizes affinity microcolumn chromatography to complement downstream plate-based processing in aptamer selections. This device is reconfigurable and is able to operate in serial and/or parallel…
Arturo Tozzi, James F. Peters, Ottorino Ori
James F. Peters Department of Electrical and Computer Engineering, University of Manitoba 75A Chancellor's Circle, Winnipeg, MB R3T 5V6, Canada and Department of Mathematics, Adıyaman University, 02040 Adıyaman, Turkey, Department of Mathematics, Faculty of Arts and Sciences, Adıyaman University 02040 Adıyaman, Turkey…
Denis Larionov, Nikolay Bazenkov, М. Г. Киселев
Continual learning is a key feature of biological neural systems, but artificial neural networks often suffer from catastrophic forgetting. Instead of backpropagation, biologically plausible learning algorithms may enable stable continual learning. This study proposes columnar-organized spiking neural networks (SNNs)…
Linh T.P. Le, Omkar Hegde, Wei-Huan Wu, Ayesha Ejaz + 3 more
High-throughput microfluidics has transformed biomedical research by enabling precise and parallel sample handling, but most devices are single-use due to channel occlusion and contamination from experiments. Alongside low fabrication yield and reduced experimental success associated with dense microfeatures, this…
Jialin Wu, Hui Fang, Jun Zhang, Sheng Yan
The advancement of microfluidics has enabled numerous discoveries and technologies in life sciences. However, due to the lack of industry standards and configurability, the design and fabrication of microfluidic devices require highly skilled technicians. The diversity of microfluidic devices discourages biologists and…
Xiaochen Lai, Mingpeng Yang, Hao Wu, Dachao Li + 1 more
This review mainly studies the development status, limitations, and future directions of modular microfluidic systems. Microfluidic technology is an important tool platform for scientific research and plays an important role in various fields. With the continuous development of microfluidic applications, conventional…
Arno Granier, Walter Senn
Both biological cortico-thalamic networks and artificial transformer networks use canonical computations to perform a wide range of cognitive tasks. In this work, we propose that the structure of cortico-thalamic circuits is well suited to realize a computation analogous to multihead self-attention, the main…
Pojchanun Kanitthamniyom, Aiwu Zhou, Shilun Feng, Aiqun Liu + 2 more
'Shawn Vasoo' 'Yi Zhang'] Magnetic digital microfluidics (MDM) manipulates fluids in the form of droplets on an open substrate, and incorporates surface energy traps (SETs) to facilitate the droplet manipulation. Conventional MDM devices are fabricated monolithically, which makes it difficult to modify the device…
Yi Liu, Fuliang Wang, Roberto Pizzoferrato
Local electrochemical deposition (LECD) is an innovative additive manufacturing technology capable of achieving precise deposition of metallic microstructures. This study delves into the ramifications of pivotal operational parameters-namely, the initial electrode gap, deposition voltage, and additive concentration-on…
Siyu Chen, Zezhi Li, Quanping Yan, Chenfeng Hua + 6 more
'Kejian Liu' 'Junwei Zhao' 'Guangxiang Jin' 'Xiang Li' 'Fuwei Xie'] Formaldehyde poses a significant threat to human health, yet its toxicity assessment is limited by current detection methods. This study developed a modular biomimetic lung chip which consists of gas concentration gradient generator module and cell…
Adeel Ahmed, Indranil M. Joshi, Mehran Mansouri, Ann M. Byerley + 3 more
Randomly oriented type I collagen (COL1) fibers in the extracellular matrix (ECM) in vivo are reorganized by biophysical forces into aligned domains extending several millimeters and with varying degrees of fiber alignment. These aligned fibers can transmit traction forces, guide tumor cell migration, facilitate…
Sergio Garcia, Cong T. Trinh
Microbial metabolism can be harnessed to produce a large library of useful chemicals from renewable resources such as plant biomass. However, it is laborious and expensive to create microbial biocatalysts to produce each new product. To tackle this challenge, we have recently developed modular cell (ModCell) design…
Sergio Garcia, Cong T. Trinh
Living cells optimize their fitness against constantly changing environments to survive. Goal attainment optimization is a mathematical framework to describe the simultaneous optimization of multiple conflicting objectives that must all reach a performance above a threshold or goal. In this study, we applied goal…
Graham M. Gibson, Robert B. Archibald, Mark Main, Akhil Kallepalli
Delivering light to an object is one of the key steps in any imaging exercise. Tools such as LEDs and lasers are available to achieve this. These components are integrated into systems such as microscopy, medical imaging, remote sensing, and so many more. Motivated by the need for affordable and open access…
Brandon Wilbanks, Donovan S. Layton, Sergio Garcia, Cong T. Trinh
When aiming to produce a target chemical at high yield, titer, and productivity, various combinations of genetic parts available to build the target pathway can generate a large number of strains for characterization. This engineering approach will become increasingly laborious and expensive when seeking to develop…
Sergio Garcia, Cong T. Trinh
Diversity of cellular metabolism can be harnessed to produce a large space of molecules. However, development of optimal strains with high product titers, rates, and yields required for industrial production is laborious and expensive. To accelerate the strain engineering process, we have recently introduced a modular…
Campagnari, Claudio, Cho, Sungwoong + 46 more
Claudio Campagnari ID 1 , Sungwoong Cho† 2 , Suyong Choi ID 2 , Seokju Chung ID ‡2 , Matthew Citron ID 3 , Albert De Roeck ID 4 , Martin Gastal 4 , Seungkyu Ha ID 2 , Andy Haas 5 , Christopher Scott Hill ID 6 , Byeong Jin Hong 2 , Haeyun Hwang 2 , Insung Hwang ID § 2 , Hoyong Jeong ID 2 , Hyunki Moon ID 2 , Jayashri…
Stephen Harwood, Maximilian Palkowitz, Cara Gannett, Paulo Perez + 5 more
The synthesis of terpenes is a large field of research that is woven deeply into the history of chemistry. Terpene biosynthesis is a case-study of how the logic of a modular design can lead to diverse structures with unparalleled efficiency. This work mimics Nature by leveraging modern Ni-catalyzed electrochemical…
Anna Matuszyńska, Oliver Ebenhöh, Matias D. Zurbriggen, Daniel C. Ducat + 1 more
Synthetic biology designs and constructs new biological parts, devices and systems with predetermined functionalities. With the unlimited ability to synthesise any DNA and RNA and transfer it to almost any organism, we are at the dawn of a new era in which biology is being recreated in ways never before possible. It…
Authors not listed
The capacity to pattern biomolecules within microfluidic devices expands the scope of microfluidic technologies. In such patterned systems, surface-bound components remained localized, while the microfluidic network supplies reagents and removes waste products. This approach has enabled continuous protein expression…
Silvia Tea Calzuola, Gwenyth Newman, Thomas Feaugas, Cécile M. Perrault + 5 more
Microfluidic devices with integrated membranes that enable control of mass transport in constrained environments have shown considerable growth over the last decade. Membranes are a key component in several industrial processes such as chemical, pharmaceutical, biotechnological, food, and metallurgy separation…