26 papers · ranked by Valyu relevance
Robert L. Perlman
The use of mice as model organisms to study human biology is predicated on the genetic and physiological similarities between the species. Nonetheless, mice and humans have evolved in and become adapted to different environments and so, despite their phylogenetic relatedness, they have become very different organisms.…
Channabasavaiah B. Gurumurthy, Kevin C. Kent Lloyd
Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. This At a Glance article highlights several recent technical advances in mouse genome manipulation that have transformed our ability to manipulate and study gene expression in the…
Franck Dernoncourt
—In a few months the computer mouse will be half-acentury-old. It is known to have many drawbacks, the main ones being: loss of productivity due to constant switching between keyboard and mouse, and health issues such as RSI. Like the keyboard, it is an unnatural human-computer interface. However the vast majority of…
Bart Ellenbroek, Jiun Youn
Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical science compared to rats. This shift was primarily instigated by…
Mohamad Fakih, Rahul Dharmaji, Youssef Mahmoud, Halima Bouzidi + 1 more
—Modern optical mouse sensors, with their advanced precision and high responsiveness, possess an often overlooked vulnerability: they can be exploited for side-channel attacks. This paper introduces Mic-E-Mouse, the first-ever side-channel attack that targets high-performance optical mouse sensors to covertly eavesdrop…
Holger Maier, Christoph Lengger, Bruno Simic, Helmut Fuchs + 2 more
'Valérie Gailus-Durner' 'Martin Hrabé de Angelis'] Background Large-scale, comprehensive and standardized high-throughput mouse phenotyping has been established as a tool of functional genome research by the German Mouse Clinic and others. In all these projects, vast amounts of data are continuously generated and need…
Saori Mizuno-Iijima, Toshiaki Nakashiba, Shinya Ayabe, Hatsumi Nakata + 10 more
'Hatsumi Nakata' 'Fumio Ike' 'Noriko Hiraiwa' 'Keiji Mochida' 'Atsuo Ogura' 'Hiroshi Masuya' 'Shoko Kawamoto' 'Masaru Tamura' 'Yuichi Obata' 'Toshihiko Shiroishi' 'Atsushi Yoshiki'] The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The…
Cristina Sisu, Paul Muir, Adam Frankish, Ian Fiddes + 8 more
Pseudogenes are ideal markers of genome remodeling. In turn, the mouse is an ideal platform for studying them, particularly with the availability of developmental transcriptional data and the sequencing of 18 strains. Here, we present a comprehensive genome-wide annotation of the pseudogenes in the mouse reference…
Bo Hu, Bryan Seybold, Shan Yang, David A. Ross + 3 more
'Graham Ruby' 'Yi Liu'] We present a method to infer the 3D pose of mice, including the limbs and feet, from monocular videos. Many human clinical conditions and their corresponding animal models result in abnormal motion, and accurately measuring 3D motion at scale offers insights into health. The 3D poses improve…
Anne Habedank, Birk Urmersbach, Pia Kahnau, Lars Lewejohann
Existing methods for analysis of home cage based preference tests are either time consuming, not suitable for group management, expensive and/or based on proprietary equipment that is not freely available. For this reason, we developed an automated system for group housed mice based on radio frequency identification…
Sunjun Kim, Byungjoo Lee, Thomas van Gemert, Antti Oulasvirta
Computer mice have their displacement sensors in various locations (center, front, and rear). However, there has been little research into the effects of sensor position or on engineering approaches to exploit it. This paper first discusses the mechanisms via which sensor position affects mouse movement and reports the…
Feixiang Zhou, Zheheng Jiang, Zhihua Liu, Fang Chen + 7 more
'Lei Tong' 'Zhile Yang' 'Haikuan Wang' 'Minrui Fei' 'Ling Li' 'Huiyu Zhou'] Abstract—Automated analysis of mouse behaviours is crucial for many applications in neuroscience. However, quantifying mouse behaviours from videos or images remains a challenging problem, where pose estimation plays an important role in…
Bernardo A. Arús, Emily D. Cosco, Joycelyn Yiu, Ilaria Balba + 3 more
Extracting biological information from awake and unrestrained mice is imperative to in vivo basic and pre-clinical research. Accordingly, imaging methods which preclude invasiveness, anesthesia, and/or physical restraint enable more physiologically relevant biological data extraction by eliminating these extrinsic…
Sheldon L. Reeves, Kelsey E. Fleming, Lin Zhang, Annalisa Scimemi + 1 more
'Timothée Poisot'] Grooming is a complex and robust innate behavior, commonly performed by most vertebrate species. In mice, grooming consists of a series of stereotyped patterned strokes, performed along the rostro-caudal axis of the body. The frequency and duration of each grooming episode is sensitive to changes in…
Yingjian Li, Xiaoya Huang, Jikai Deng, Xue Tan + 3 more
Animal models are essential for understanding the pathogenesis of SARS-CoV-2 and for developing therapeutic strategies. Replicon delivery particles (RDPs) were a component of trans-complementary systems for SARS-CoV-2, which is a safe and convenient tool in researching SARS-CoV-2 in animal biosafety level-II laboratory…
Joanna Buchthal, Emma J. Chory, Zachary Hill, Christy Dennison + 9 more
CRISPR/Cas9 technology has revolutionized the production of animal models by reducing experimental timelines, slashing costs and streamlining gene editing, leading to a rapid expansion in the number of unique models for the study of human disease and gene function. However, most non-model animals, many of which are…
Nyle Siddiqui, Rushit Dave, Naeem Seliya
—Mouse dynamics has grown in popularity as a novel, irreproducible behavioral biometric. Datasets which contain general, unrestricted mouse movements from users are sparse in the current literature. The Balabit mouse dynamics dataset, produced in 2016, was made for a data science competition and despite some of its…
Simon Khan, Daqing Hou
Utilization of the Internet in our everyday lives has made us vulnerable in terms of privacy and security of our data and systems. Therefore, there is a pressing need to protect our data and systems by improving authentication mechanisms, which are expected to be low cost, unobtrusive, and ideally ubiquitous in nature.…
Masataka Nakayama, Shigeru Kyuwa
Mouse hepatitis virus (MHV) is a murine coronavirus and one of the most important pathogens in laboratory mice. Although various strains of MHV have been isolated, they are generally excreted in the feces and transmitted oronasally via aerosols and contaminated bedding. In this study, we attempted to determine the…
Anna Fagre, Juliette Lewis, Miles Eckley, Shijun Zhan + 11 more
Coronavirus disease-19 (COVID-19) emerged in November, 2019 in China and rapidly became pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus originated in horseshoe bats (Rhinolophus spp.) and likely underwent a recombination event in an intermediate host prior to entry into human…
Timm O. Koller, Ullrich Scheid, Teresa Kösel, Jennifer Herrmann + 23 more
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against Mycobacterium tuberculosis. To ensure compound…
Rananjaya Gamage, Bradley Smith
Indocyanine Blue (ICB) is the deep-red, pentamethine analogue of the widely used clinical near-infrared heptamethine cyanine dye, Indocyanine Green (ICG). The two fluorophores have the same number of functional groups and molecular charge and vary only by a single vinylene unit in the polymethine chain which produces a…
Authors not listed
Imaging small polar metabolites and analyzing their in vivo dynamics with stable isotope labeled (SIL) tracing through various biochemical pathways, including citric acid (TCA) cycle, glycolysis, and amino acid metabolism, has gained substantial interest over the years. However, imaging these small polar metabolites…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…
Yan-Zhen Wang, Peng-Cheng Mei, Pei-Rong Bai, Na An + 4 more
Bile acids (BAs) are a class of vital gut microbiota-host cometabolites, and they play an important role in maintaining gut microbiota-host metabolic homeostasis. Very recently, a new mechanism of BA anabolic metabolism mediated by gut microbiota (BA-amino acid conjugation) has been revealed, which provides a…
Rebecca Howell, Rinco Wang, David McDonald, David Spiegel
We present the application of Angiopep-2 as a molecular degrader of extracellular proteins (MoDE) promoting target protein removal by both transcytosis and lysosomal degradation mechanisms in brain endothelial cells. The accumulation of pathogenic proteins is a hallmark of many neurodegenerative diseases, and removal…