21 papers · ranked by Valyu relevance
Rebecca Kohnken, Pierluigi Porcu, Anjali Mishra
Murine models have been adopted as a significant and powerful tool in the study of cancer. The applications of murine models of cancer are numerous: mechanism discovery, oncogenesis, molecular genetics, microenvironment, metastasis, and therapeutic efficacy. Leukemias and lymphomas are a group of highly heterogeneous…
Bo-Tao Zhang, Jia-Ying Xu, Wei Wang, Yang Zeng + 1 more
There is increasing evidence that obesity is associated with the occurrence and development of malignant tumors. When studying the relationship between obesity and malignant tumors, it is very important to choose an appropriate animal model. However, BALB/c nude mice and other animals commonly used to study tumor…
Vinodhini Krishnakumar, Siva Sundara Kumar Durairajan, Kalichamy Alagarasu, Min Li + 1 more
'Kalichamy Alagarasu' 'Min Li' 'Aditya Prasad Dash'] Well-developed mouse models are important for understanding the pathogenesis and progression of immunological response to viral infections in humans. Moreover, to test vaccines, anti-viral drugs and therapeutic agents, mouse models are fundamental for preclinical…
Dale A. Begley, Debra M. Krupke, John P. Sundberg, Emily L. Jocoy + 3 more
'Joel E. Richardson' 'Steven B. Neuhauser' 'Carol J. Bult'] Title: ABSTRACT The laboratory mouse has served for decades as an informative animal model system for investigating the genetic and genomic basis of cancer in humans. Although thousands of mouse models have been generated, compiling and aggregating relevant…
Natal van Riel, Ralph Müller, Enrico Dall’Ara
Computational models can be used to study the mechanistic phenomena of disease. Current mechanistic computer simulation models mainly focus on (patho)physiology in humans. However, often data and experimental findings from preclinical studies are used as input to develop such models. Biological processes underlying…
Yingjian Li, Xiaoya Huang, Jikai Deng, Xue Tan + 3 more
Animal models are essential for understanding the pathogenesis of SARS-CoV-2 and for developing therapeutic strategies. Replicon delivery particles (RDPs) were a component of trans-complementary systems for SARS-CoV-2, which is a safe and convenient tool in researching SARS-CoV-2 in animal biosafety level-II laboratory…
Yuan Zhong, Jingxiang Sun, Zhongbin Zhang, Liang An + 1 more
Laboratory mice, as widely used model animals, are fundamental to disease modeling and neuroscience studies. Understanding their three-dimensional (3D) motion dynamics provides valuable insights for medical and life sciences[[13]]. Over the last decade, deep learning has revolutionized both 2D and 3D animal pose…
Jesús Ruberte, Paul N. Schofield, John P. Sundberg, Alfonso Rodriguez-Baeza + 2 more
'Alfonso Rodriguez-Baeza' 'Ana Carretero' 'Colin McKerlie'] The laboratory mouse is the foremost mammalian model used for studying human diseases and is closely anatomically related to humans. Whilst knowledge about human anatomy has been collected throughout the history of mankind, the first comprehensive study of the…
Jesse I. Gilmer, Susan Coltman, Geraldine C. Velasco, John R. Hutchinson + 3 more
Mice are key model organisms in genetics, neuroscience and motor systems physiology. Fine motor control tasks performed by mice have become widely used in assaying neural and biophysical motor system mechanisms, including lever or joystick manipulation, and reach-to-grasp tasks (4; 6; 13). Although fine motor tasks…
Alpha Tom Kodamullil, Anandhi Iyappan, Reagon Karki, Sumit Madan + 2 more
'Erfan Younesi' 'Martin Hofmann-Apitius'] Perturbance in inflammatory pathways have been identified as one of the major factors which leads to neurodegenerative diseases (NDD). Owing to the limited access of human brain tissues and the immense complexity of the brain, animal models, specifically mouse models, play a…
Malachy Guzman, Brian Geuther, Gautam Sabnis, Vivek Kumar
Changes in body mass are a key indicator of health and disease in humans and model organisms. Animal body mass is routinely monitored in husbandry and preclinical studies. In rodent studies, the current best method requires manually weighing the animal on a balance which has at least two consequences. First, direct…
Feixiang Zhou, Zheheng Jiang, Zhihua Liu, Fang Chen + 7 more
'Lei Tong' 'Zhile Yang' 'Haikuan Wang' 'Minrui Fei' 'Ling Li' 'Huiyu Zhou'] Abstract—Automated analysis of mouse behaviours is crucial for many applications in neuroscience. However, quantifying mouse behaviours from videos or images remains a challenging problem, where pose estimation plays an important role in…
Hyungju Jeon, Jiwon Kim, Jayoung Kim, Yoon Kyoung Choi + 5 more
The gray mouse lemur (Microcebus murinus), one of the smallest living primates, emerges as a promising model organism for neuroscience research. This is due to its genetic similarity to humans, its evolutionary position between rodents and humans, and its primate-like features encapsulated within a rodent-sized brain.…
Teng Xu, Taotao Zhou, Youjia Wang, Peng Yang + 11 more
'Kuixiang Shao' 'Zifeng Tang' 'Yifei Liu' 'Xinyuan Chen' 'Hongshuang Wang' 'Xiaohui Wang' 'Huoqing Luo' 'Jingya Wang' 'Ji Hu' 'Jingyi Yu'] behaviors, fall short due to limited interpretability and reliance on manual labeling, which restricts the exploration of the full behavioral spectrum. Here, we introduce MouseGPT…
Koichi Handa, Daichi Fujita, Mariko Hirano, Saki Yoshimura + 2 more
Given the aging populations in advanced countries globally, many pharmaceutical companies have focused on developing central nervous system (CNS) drugs. However, due to the blood-brain barrier, drugs do not easily reach the target area in the brain. Although conventional screening methods for drug discovery involve the…
Hamed R. Tavakoli, Fawad Ahmed, Ali Borji, Jorma Laaksonen
This paper revisits visual saliency prediction by evaluating the recent advancements in this field such as crowdsourced mouse tracking-based databases and contextual annotations. We pursue a critical and quantitative approach towards some of the new challenges including the quality of mouse tracking versus eye tracking…
Franck Dernoncourt
—In a few months the computer mouse will be half-acentury-old. It is known to have many drawbacks, the main ones being: loss of productivity due to constant switching between keyboard and mouse, and health issues such as RSI. Like the keyboard, it is an unnatural human-computer interface. However the vast majority of…
Rananjaya Gamage, Bradley Smith
Indocyanine Blue (ICB) is the deep-red, pentamethine analogue of the widely used clinical near-infrared heptamethine cyanine dye, Indocyanine Green (ICG). The two fluorophores have the same number of functional groups and molecular charge and vary only by a single vinylene unit in the polymethine chain which produces a…
Authors not listed
Imaging small polar metabolites and analyzing their in vivo dynamics with stable isotope labeled (SIL) tracing through various biochemical pathways, including citric acid (TCA) cycle, glycolysis, and amino acid metabolism, has gained substantial interest over the years. However, imaging these small polar metabolites…
Simon Khan, Daqing Hou
Utilization of the Internet in our everyday lives has made us vulnerable in terms of privacy and security of our data and systems. Therefore, there is a pressing need to protect our data and systems by improving authentication mechanisms, which are expected to be low cost, unobtrusive, and ideally ubiquitous in nature.…
Carley V. Cook, Ariel M. Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important…