13 papers · ranked by Valyu relevance
Paul G. Fahey, Taliah Muhammad, Cameron Smith, Emmanouil Froudarakis + 7 more
In primates and most carnivores, neurons in primary visual cortex are spatially organized by their functional properties. For example, neurons with similar orientation preferences are grouped together in iso-orientation domains that smoothly vary over the cortical sheet. In rodents, on the other hand, neurons with…
Xu Han, Ben Vermaercke, Vincent Bonin
Understanding visual processing requires a detailed description of computations performed by neurons across stages of the visual system. However, the diverse tunings of neurons beyond the primary visual cortex (V1) have yet to be fully characterized. Using two-photon calcium imaging and stochastic visual stimuli, we…
Alessandro La Chioma, Tobias Bonhoeffer, Mark Hübener
Binocular disparity, the difference between left and right eye images, is a powerful cue for depth perception. Many neurons in the visual cortex of higher mammals are sensitive to binocular disparity, with distinct disparity tuning properties across primary and higher visual areas. Mouse primary visual cortex (V1) has…
Declan P. Rowley, Madineh Sedigh-Sarvestani
The mouse has become one of the main organisms for studies of the visual system. As a result, there is increased effort to understand universal principles of visual processing by comparing the mouse visual system to that of other species. In primates and other well-studied species including cats and tree shrews, the…
Zaina A. Zayyad, John H. R. Maunsell, Jason N. MacLean
When multiple stimuli appear together in the receptive field of a visual cortical neuron, the response is typically close to the average of that neuron’s response to each individual stimulus. The departure from a linear sum of each individual response is referred to as normalization. In mammals, normalization has been…
Mai M. Morimoto, Emi Uchishiba, Aman B. Saleem
Context dependent top-down modulation in visual processing has been a topic of wide interest. Recent findings on context dependent modulation, combined with the tools available to investigate network mechanisms in the mouse, make the mouse primary visual cortex an ideal system to investigate context-dependent…
Luis O. Jimenez, Elaine Tring, Joshua T. Trachtenberg, Dario L. Ringach
Local populations of neurons in mouse visual cortex exhibit diverse tuning preferences. We show this seeming disorder can be untangled — the similarity of tuning between pairs of neurons is correlated better with the overlap between their receptive fields in visual space rather than with their distance in the cortex.…
Eve Ben Yehoshua, Hamutal Slovin
Recently, mice became a popular research model for the visual system including objects processing. However, while primates use their fovea to inspect objects at high resolution, mice have low visual acuity and lack a foveal region. Thus, how objects are encoded in the visual cortex of mice and whether monkeys and mice…
Christopher P Burgess, Armin Lak, Nicholas A Steinmetz, Peter Zatka-Haas + 11 more
Research in neuroscience relies increasingly on the mouse, a mammalian species that affords unparalleled genetic tractability and brain atlases. Here we introduce high-yield methods for probing mouse visual decisions. Mice are head-fixed, which facilitates repeatable visual stimulation, eye tracking, and brain access.…
Yiyi Yu, Jeffrey N. Stirman, Christopher R. Dorsett, Spencer L. Smith
Mice have a constellation of higher visual areas, but their functional specializations are unclear. Here, we used a data-driven approach to examine neuronal representations of complex visual stimuli across mouse higher visual areas, measured using large field-of-view two-photon calcium imaging. Using specialized…
Thi Ngoc Anh Dinh, Won Beom Jung, Hyun-Ji Shim, Seong-Gi Kim
The functional characteristics of the mouse visual system have not previously been well explored using fMRI. In this research, we examined 9.4 T BOLD fMRI responses to visual stimuli of varying pulse durations (1 – 50 ms) and temporal frequencies (1 – 10 Hz) under ketamine and xylazine anesthesia, and compared fMRI…
Simon Weiler, Vahid Rahmati, Marcel Isstas, Johann Wutke + 9 more
Tactile sensation and vision are often both utilized for the exploration of objects that are within reach though it is not known whether or how these two distinct sensory systems might combine such information. Here in mice we find that stimulation of the contralateral whisker array suppresses visually evoked activity…
Dorothee M. Günther, Mykhailo Y. Batiuk, Viktor Petukhov, Romain De Oliveira + 4 more
Recently, single-cell RNA-sequencing (scRNA-seq) has enabled unprecedented insights to the cellular landscape of the brains of many different species, among them the rhesus macaque as a key animal model. Building on previous, broader surveys of the macaque brain, we closely examined five immediately neighboring areas…