20 papers · ranked by Valyu relevance
Peijia Yu, Ha Yun Anna Yoon, Yuhan Yang, Yunlong Xu + 4 more
The quality of sensory information flow in the brain may be affected by uninstructed free animal behavior. However, the specific circuit pathways that merge sensory and free behavior remain obscure. In mouse primary visual cortex (V1), we combine two-photon calcium imaging of cortical neurons and thalamo-cortical LGN…
Ronan T. O’Shea, Xue-Xin Wei, Nicholas J. Priebe
Natural environments contain behaviorally relevant information along many stimulus dimensions, each of which sensory systems must encode in order to guide behaviors. For example, the mammalian visual cortex encodes features of visual scenes such as spatial information related to object identity and temporal information…
Mathis Bassler, Lilian Emming, Christopher J. Whyte, Gerjan Huis In ‘t Veld + 2 more
We investigated whether binocularly conflicting stimuli adapted from primate binocular rivalry studies could induce binocular response suppression in mouse visual cortex. We presented binocularly conflicting stimuli adapted from the paradigm of continuous flash suppression to awake and anesthetized mice and examined…
Atika Syeda, Miguel Angel Nunez-Ochoa, Lin Zhong, Marius Pachitariu + 1 more
Neural activity in mouse primary visual cortex (V1) correlates strongly with orofacial movements. Such strong modulation has not been found in the primate visual cortex during eye fixation [1], which led to the suggestion that the modulation may primarily depend on eye movements in both species [2]. Here we examined…
Nikhil Bhatla, Kathryn Cheong, Sho Takahashi, Corliss Lay + 26 more
Title: SUMMARY The phenomenon of blindsight provides a unique opportunity to uncover brain areas important for conscious vision. Patients with blindsight lose the conscious experience of seeing while still being able to detect and locate visual stimuli. Blindsight occurs after damage to the primary visual cortex (V1).…
Diya Prasanth, Matthew Tivnan
We present BioNIC, a multi-layer feedforward neural network for emotion classification, inspired by detailed synaptic connectivity graphs from the MICrONs dataset [1, 2]. At a structural level, we incorporate architectural constraints derived from a single cortical column of the mouse Primary Visual Cortex(V1)…
Mai M Morimoto, Julien Fournier, Aman B. Saleem
Neurons in cortical areas often integrate signals from different origins. In the primary visual cortex (V1), neural responses are modulated by non-visual context such as the animal's position. However, the spatial profile of these position signals across the environment remains unknown. Here, we propose a new framework…
Konstantin F. Willeke, Polina Turishcheva, Alex Gilbert, Goirik Chakrabarty + 17 more
Scaling data and artificial neural networks has transformed AI, driving breakthroughs in language and vision. Whether similar principles apply to modeling brain activity remains unclear. Here we leveraged a dataset of 3.1 million neurons from the visual cortex of 73 mice across 323 sessions, totaling more than 150…
Mathis Bassler, Lilian Emming, Christopher J. Whyte, Gerjan Huis In ’t Veld + 2 more
Title: Summary We investigated whether binocularly conflicting stimuli may induce binocular response suppression in the mouse visual cortex. We presented stimuli adapted from the paradigm of continuous flash suppression to awake and anesthetized mice and examined neuronal responses in visual areas V1 and LM. Neuronal…
Kuwook Cha, Aline Giselle Rangel Olguin, Reza Sharif-Naeini, Erik P. Cook + 1 more
Title: Summary Humans and other mammals show spatial biases in their perception of visual features. Although the primary visual cortex is considered a source of these biases, earlier structures may also contribute. Recent work shows feature biases in the retina, but little is known about how they evolve as signals flow…
Bertram, Johannes, Dyballa, Luciano + 6 more
Foundation models have shown remarkable success in fitting biological visual systems; however, their black-box nature inherently limits their utility for understanding brain function. Here, we peek inside a SOTA foundation model of neural activity (Wang et al., 2025) as a physiologist might, characterizing each…
Lupeng Wang, Christian Quaia, Kerry Elliott, Kara K. Cover + 1 more
Visual selective attention is not wired into the brain fully formed and immutable but is acquired and refined as animals learn by interacting with their environment. Here we investigated this process by studying neuronal activity in the superior colliculus (SC) of male and female mice that learned different meanings of…
Katharine Borges, Qiqi Xian, Rongwen Lu, Yajie Liang + 3 more
The superior colliculus (SC) is critical in detecting and responding to salient stimuli. However, it is unknown whether salience signals are inherited from external sources such as retina and cortex, or arise from the intrinsic circuitry within SC. We used in vivo 2-photon calcium imaging with adaptive optics to…
Matteo Tripodi, Hiroki Asari
Retinotopy is a fundamental organizational principle of the visual system, where neighboring neurons represent adjacent points in visual space. This spatial relationship is established by precise anatomical wiring across successive areas, from the retina to the lateral geniculate nucleus (LGN) to the visual cortex. To…
Federica B. Rosselli, Marc Büttner, Annalisa Bucci, Felix Franke
Animals need to infer properties of the environment that are only ambiguously encoded by neurons in the sensory periphery. In vision, local edge motion seen through small receptive fields does not uniquely specify the direction of global or object motion. Can these ambiguous local motion signals drive behavior…
Li Zhaoping
Progress in vision research has been slower downstream than upstream of primary visual cortex (V1). Traditional frameworks have largely overlooked a central constraint: only a tiny fraction of retinal input is recognized. Thus, to a first approximation, vision is better formulated as looking and seeing through a…
Carmen Anna Pizka, David Linhardt, Adam Coates, Dominik Zuschlag + 2 more
The claustrum is a thin, bilateral sheet of grey matter between the insula and putamen that stands out by its high interconnectivity with almost the entire cortex. Despite continuing research in humans and animals, its functional role remains largely unknown. In the present study, we explored the topographic…
Shengyang Luo, Shengyao Luo, Xiaolei Guo, Fengze Zhang + 2 more
Tutorial videos are widely used for learning feature-rich software, yet following screencast tutorials often breaks down in practice. Through a survey and contextual inquiry, we found that learners frequently rewind or get stuck because critical input information, especially mouse actions and keyboard-modified…
Authors not listed
This paper formally defines an operational isomorphism between spectral damping in molecular vibronic systems and neuromodulatory control in biological sensory systems. Without asserting causal continuity or physical identity across scales, we show that both domains instantiate the same class of output-selective…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…