24 papers · ranked by Valyu relevance
Leonardo Bich, Thomas Pradeu, Jean-François Moreau
The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a…
Thomas C. Day, Pedro Márquez-Zacarías, Pablo Bravo, Aawaz R. Pokhrel + 3 more
'Kathryn A. MacGillivray' 'William C. Ratcliff' 'Peter J. Yunker'] The diversity of multicellular organisms is, in large part, due to the fact that multicellularity has independently evolved many times. Nonetheless, multicellular organisms all share a universal biophysical trait: cells are attached to each other. All…
Juliet C. Coates, Umm-E-Aiman, Bénédicte Charrier
Living organisms are unicellular, composed of a single cell, or multicellular, where a group of up to ~1012 cells functions co-operatively (Kaiser, ). All multicellular organisms evolved from single-celled ancestors; every individual organism arises from a unicell and reproduces by forming unicells. Multicellularity…
Kyle R. Allison
Biological organisms are simple at heart: cells, their basic units, perform a variety of behaviors by expressing proteins from DNA-encoded genes. Gene expression though depends on sets of often-convoluted regulatory interactions known as gene networks, contributing to biology's apparent complexity. Even in Escherichia…
Pina Marotta, Antonella Ruggiero, Gust Bilcke
The emergence of multicellular organisms has been one of the major transitions during the evolutionary history of life on Earth (), with multicellularity evolving several times independently in the Tree of Life (; ; ). Multicellularity can be simply defined as the result of cellular aggregation () or, if more stringent…
Paula Gregorio-Godoy, Guillermo Pérez del Pulgar, Marcos Rodríguez-Regueira, Alfonso Rodríguez-Patón
Division of Labor can occur as a consequence of a major evolutionary transition such as multicellularity but is also found in societies of similar individuals like microbes. It has been defined as a process that occurs when cooperating individuals specialize to carry out specific tasks in a distributed manner. This…
Ricardo O. Ramirez Flores, Philipp Schäfer, Leonie Küchenhoff, Julio Sáez-Rodríguez
'Julio Sáez-Rodríguez'] The application of single-cell molecular profiling coupled with spatial technologies has enabled charting cellular heterogeneity in reference tissues and in disease. This new wave of molecular data has highlighted the expected diversity of single-cell dynamics upon shared external queues and…
László G. Nagy, Krisztina Krizsán
Complex multicellularity comprises the most advanced level of organization evolved on Earth. It has evolved only a few times in metazoans, green plants, brown and red algae and fungi. Compared to other lineages, the evolution of multicellularity in fungi follows different principles; both simple and complex…
Matthew D. Herron, Josh M. Borin, Jacob C. Boswell, Jillian Walker + 4 more
The transition from unicellular to multicellular life was one of a few major events in the history of life that created new opportunities for more complex biological systems to evolve. However, understanding the proximate and ultimate causes of the resulting increases in complexity remains a major challenge for…
Anahit Penesyan, Ian T. Paulsen, Staffan Kjelleberg, Michael R. Gillings
'Michael R. Gillings'] Biofilms are organised heterogeneous assemblages of microbial cells that are encased within a self-produced matrix. Current estimates suggest that up to 80% of bacterial and archaeal cells reside in biofilms. Since biofilms are the main mode of microbial life, understanding their biology and…
Alexandre P. Fernandes, Renske M. A. Vroomans, Enrico Sandro Colizzi
During the transition to multicellularity, cells evolved novel regulatory mechanisms to coordinate cell division and differentiation, which enabled the emergence of group reproduction. These mechanisms were repurposed from molecular and cellular traits that once mediated interactions between single-celled organisms.…
Eduardo P. Olimpio, Diego R. Gomez‐Alvarez, Hyun Youk
Living systems, particularly multicellular systems, often seem hopelessly complex. But recent studies have suggested that beneath this complexity, there may be unifying quantitative principles that we are only now starting to unravel. All cells interact with their environments and with other cells. Communication among…
Núria Ros-Rocher, Josean Reyes-Rivera, Uzuki Horo, Chantal Combredet + 7 more
Multicellularity evolved multiple times independently during eukaryotic diversification^1–4^. Two distinct mechanisms underpin multicellularity^5^: clonal development (serial cell division of a single precursor cell) and aggregation (in which independent cells assemble into a multicellular entity). Clonal and…
Devina Puri, Kyle R. Allison
Escherichia coli has long been a trusty companion, maintaining health in our guts and advancing biological knowledge in the laboratory. In light of recent findings, we discuss E. coli's multicellular self-organization and develop general ideas for multicellularity, including the necessity for multicellular dynamics and…
Alexandre Porcher Fernandes, Renske M. A. Vroomans, Enrico Sandro Colizzi
During the transition to multicellularity, nascent multicellular organisms evolved reproductive strategies that relied on coordinating behaviour across cells in the group. Cell-cell interactions that once occurred between independent single-celled organisms in an ecological context were integrated into the…
James Edward Trosko, Maurizio Battino
Throughout the history of biological/medicine sciences, there has been opposing strategies to find solutions to complex human disease problems. Both empirical and deductive approaches have led to major insights and concepts that have led to practical preventive and therapeutic benefits for the human population. The…
Hanna Isaksson, Peter Lind, Eric Libby
Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is…
Eran Agmon
> Abstract: Composition is a powerful principle for systems biology, focused on the interfaces, interconnections, and orchestration of distributed processes. Whereas most systems biology models focus on the structure or dynamics of specific subsystems in controlled conditions, compositional systems biology aims to…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Carley V. Cook, Ariel M. Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important…
Authors not listed
The Single-probe is a multifunctional device that can be coupled to mass spectrometry (MS) for molecular analysis of microscale samples, such as single cells, tissue slices, and multicellular spheroids, under ambient conditions. In Single-probe single cell MS (SCMS) studies, this technique leverages direct sampling and…
Authors not listed
Vertex models have been established as powerful tools for the cell-based simulation of epithelial tissues as they allow a detailed description of their mechanical development with respect to the properties of individual cells. Thus, they suit the challenges of simulating intestinal organoids which arise from the…
Juerg Straubhaar, Alexandria D’Souza, Zachary Niziolek, Bogdan Budnik
Single-cell analysis has clearly established itself in biology and biomedical fields as an invaluable tool that allows one to comprehensively understand the relationship between cells, including their types, states, transitions, trajectories, and spatial position. Scientific methods such as fluorescence labeling…
Amit Kahana, Lior Segev, Doron Lancet
The origin of life must have involved an unlikely transition from chaotic chemistry to reproducing supramolecular structures. Previous quantitative analyses of reproducing mutually catalytic networks made of simple molecules have led to increasing popularity of this pre-RNA scenario for life’s origin. Here, we…