20 papers · ranked by Valyu relevance
Eike-Christian Wamhoff, Larance Ronsard, Jared Feldman, Blake M. Hauser + 8 more
Multivalent antigen display is a well-established design principle to enhance humoral immunity elicited by subunit vaccines. Protein-based virus-like particles (VLPs) are an important vaccine platform that implements this principle but also contain thymus-dependent off-target epitopes, thereby generating neutralizing…
Ana R. Humpierre, Yanira Méndez, Ahyoung Kim, Michael Niemeyer + 8 more
The ability to conjugate multiple molecules to a protein is of great interest for pharmaceutical and vaccine development, especially if this can be achieved in a one-pot procedure. Multicomponent reactions are powerful procedures that allow the assembly of complex constructs incorporating at least three molecular…
Xinyu Ning, Darshita Budhadev, Sara Pollastri, Inga Nehlmeier + 8 more
Multivalent lectin-glycan interactions (MLGIs) are widespread and vital for biology, making them attractive therapeutic tar-gets. Unfortunately, the structural and biophysical mechanisms of several key MLGIs remain poorly understood, limiting our ability to design spatially matched glycoconjugates as potent…
Zhong Wang, Xiuying Yang, Nicholas Zhou Lee, Xudong Cao + 2 more
'Jeroen Lammertyn' 'Nam-Trung Nguyen'] Aptamers are short and single-stranded DNA or RNA molecules with highly programmable structures that give them the ability to interact specifically with a large variety of targets, including proteins, cells, and small molecules. Multivalent aptamers refer to molecular constructs…
Bing Xu, Jingwei Chen, Ziyi Ding, Jianwei Hu + 3 more
'Haizeng Li' 'Huanlei Wang'] Electrochromic technology has witnessed numerous achievements in recent years both in research and commercialization. Electrochromic devices (ECD) based on different electrochemical mechanism have been developed for various applications, ranging from smart windows, thermal management, rear…
Bence Bruncsics, Wesley J. Errington, Casim A. Sarkar
Arising through multiple binding elements, multivalency can specify the avidity, duration, cooperativity, and selectivity of biomolecular interactions, but quantitative prediction and design of these properties has remained challenging. Here we present MVsim, an application suite built around a configurational network…
Rahman Basaran, Darshita Budhadev, Yuan Guo, Dejian Zhou
The dendritic cell tetrameric lectin, DC-SIGN, and its closely related endothelial cell lectin, DC-SIGNR, (collectively as DC-SIGN/R) play a key role in the binding and transmission of deadly viruses, including Ebola, HIV, HCV, and SARS-CoV-2. Their virus binding/release processes involve a gradually acidifying…
James Hooper, Darshita Budhadev, Dario Fernandez Ainaga Ainaga, Nicole Hondow + 2 more
Multivalent lectin-glycan interactions (MLGIs) are widespread and vital for biology, and also hold the key to many therapeutic applications. However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates that can potently target…
Zi Wang, Dong Zhao, Li Liang, Hengyi Wang + 3 more
Chromatic dispersion, an inherent wavelength-dependent phenomenon in optical systems, has traditionally been regarded as a detrimental effect to be minimized in imaging and display. Here, we present a paradigm shift by deliberately engineering and harnessing metalens dispersion as a functional mechanism for…
Seokyeong Lee, Jong Woong Park, Jihye Jang, Jin Woo Oh + 9 more
'Jioh Yoo' 'Jong Gun Jung' 'Hyowon Han' 'Wei Jiang' 'Chang Eun Lee' 'Jungwon Yoon' 'Kaiying Zhao' 'Cheolmin Park'] Title: Highlights 1. A rewritable triple-mode light-emitting display (RE-TriLED) was fabricated, enabled by stimuli-interactive fluorescence (FL), room-temperature phosphorescence (RTP), and…
Amelia C. Wood, Edwin C. Johnson, Ram R. R. Prasad, Mark V. Sullivan + 4 more
Peptides are important biomarkers for a range of diseases, however distinguishing different amino-acid sequences using artificial receptors remains a major challenge in biomedical sensing. Here we present a new approach to creating highly selective recognition surfaces using phage display biopanning against…
Matthew Isaacson, Lisa Ferguson, Frank Loesche, Ishani Ganguly + 5 more
Visual stimulation of animals in the laboratory is a powerful technique for studying sensory control of complex behaviors. Since commercial displays are optimized for human vision, we established a novel display system based on custom-built modular LED panels that provides millisecond refresh, precise synchronization…
Ziyang Huang, Zehao Zhang, Rongjie Zhang, Baofu Ding + 10 more
'Keyou Wu' 'Youan Xu' 'Gaokuo Zhong' 'Chuanlai Ren' 'Jiarong Liu' 'Yugan Hao' 'Menghao Wu' 'Teng Ma' 'Bilu Liu'] Title: ABSTRACT Electro-optical effect-based liquid crystal devices have been extensively used in optical modulation techniques, in which the Kerr coefficient reflects the sensitivity of the liquid crystals…
Suman Halder, Yunho Shin, Yidan Peng, Long Wang + 7 more
'Paul Schmalenberg' 'Guangkui Qin' 'Yuxi Gao' 'Ercan M. Dede' 'Deng‐Ke Yang' 'Sean P. Rodrigues'] - 1. Department of Physics, Kent State University, Kent, OH 44242 - 2. Advanced Materials and Liquid Crystal Institute, Kent State University, Kent, OH 442422 - 3. Central Research Institute, BOE Technology Group Co.…
Zhan-Ying Ma, Xianjin Liu, Yuqi Peng, Da-Sen Zhang + 2 more
'Jun-Jun Xiao'] On-chip integrated metasurface driven by in-plane guided waves is of great interests in various light field manipulation applications such as colorful augmented reality and holographic display. However, it remains a challenge to design colorful multichannel holography by a single on-chip metasurface.…
Sebastián Bordakevich, Lorena Rebón, Silvia Ledesma
Spatial light modulators are widely used to perform modulations of different properties of the electromagnetic field. In this work, a simple optimization method for general double-pass setups was developed. It takes into account the involved polarizing elements and displays, and a numerical simulation based on an…
Liam Tucker, Ethan Koland, Jasmyn Gooding, Hassan Boudjelal + 8 more
Display technologies are used extensively in the discovery of peptides and antibodies towards the development of new medicines and diagnostic tools. Phage display technology enables the filtering of <10^10^ random peptides/antibodies down to and enriched pool of candidates with favourable binding affinities. In recent…
Zeyu Yan, Hsuanling Lee, Liang He, Huaishu Peng
We present a pipeline for printing interactive and always-on magnetophoretic displays using affordable Fused Deposition Modeling (FDM) 3D printers. Using our pipeline, an end-user can convert the surface of a 3D shape into a matrix of voxels. The generated model can be sent to an FDM 3D printer equipped with an…
Zhengli Han, Christian Frydendahl, Noa Mazurski, Uriel Levy
Conventional optical displays using ITO (indium tin oxide) and LC (liquid crystal) materials present a lot of challenges in terms of long-term sustainability. We show here how it is possible to generate a cost-effective and CMOS compatible fast and full range electrically controlled RGB color display by combining…
Peter Andersson Ersman, Kathrin Freitag, Jun Kawahara, Jessica Åhlin
Electronic matrix addressed displays capable of presenting arbitrary grayscale images typically require complex device architectures including switching components to provide unique pixel addressability. Here, we demonstrate high-yield manufacturing of passive matrix addressed electrochromic displays on flexible…