18 papers · ranked by Valyu relevance
Erin E Terry, Xiping Zhang, Christy Hoffmann, Laura D Hughes + 12 more
'Scott A Lewis' 'Jiajia Li' 'Matthew J Wallace' 'Lance A Riley' 'Collin M Douglas' 'Miguel A Gutierrez-Monreal' 'Nicholas F Lahens' 'Ming C Gong' 'Francisco Andrade' 'Karyn A Esser' 'Michael E Hughes' 'Andrew Brack'] Skeletal muscle comprises a family of diverse tissues with highly specialized functions. Many acquired…
Barbara Meissner, Adam Warner, Kim Wong, Nicholas Dube + 14 more
'Sheldon J. McKay' 'Jaswinder Khattra' 'Teresa Rogalski' 'Aruna Somasiri' 'Iasha Chaudhry' 'Rebecca M. Fox' 'David M. Miller III' 'David L. Baillie' 'Robert A. Holt' 'Steven J. M. Jones' 'Marco A. Marra' 'Donald G. Moerman' 'Stuart K. Kim'] A crucial step in the development of muscle cells in all metazoan animals is…
Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda, Marco Mangone
The body muscle is an important tissue used in organisms for proper viability and locomotion. The contractile unit of the muscle is the sarcomere, which is ultimately responsible for the contraction reaction leading to movement. Although this tissue is generally well studied and characterized, and many pathways have…
Jer-En Hsu, Lloyd Ruiz, Yongha Hwang, Steve Guzman + 10 more
Skeletal muscle is essential for both movement and metabolic processes, characterized by a complex and ordered structure. Despite its importance, a detailed spatial map of gene expression within muscle tissue has been challenging to achieve due to the limitations of existing technologies, which struggle to provide…
Kevin A. Murach, Charlotte A. Peterson
In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult skeletal muscle to reveal complex cell type-specific regulation of muscle plasticity. Expanding -omics technology at single cell resolution, complimented by advanced computational approaches, promise…
Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda, Marco Mangone
'Marco Mangone'] The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout the years, we still lack a comprehensive understanding of its transcriptome and how it…
Tooba Abbassi-Daloii, Salma el Abdellaoui, Lenard M. Voortman, Thom Veeger + 7 more
Skeletal muscles support the stability and mobility of the skeleton but differ in biomechanical properties and physiological functions. The intrinsic factors that regulate muscle-specific characteristics are poorly understood. To study these, we constructed a large atlas of RNA-seq profiles from six leg muscles and two…
Alix Simon, Sarah Djeddi, Pauline Bournon, David Reiss + 2 more
'Julie Thompson' 'Jocelyn Laporte'] Title: ABSTRACT Gene differential expression and alternative splicing are mechanisms that give rise to a plethora of tissue-specific transcripts. Although these mechanisms have been studied in various tissues, their role during muscle maturation is not well understood. Because this…
Alvin T Kho, Peter B Kang, Isaac S Kohane, Louis M Kunkel
Background Mouse and human skeletal muscle transcriptome profiles vary by muscle type, raising the question of which mouse muscle groups have the greatest molecular similarities to human skeletal muscle. Methods Orthologous (whole, sub-) transcriptome profiles were compared among four mouse-human transcriptome…
Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila + 18 more
Skeletal muscle is an inherently heterogenous tissue comprised primarily of myofibers, which are historically classified into three distinct fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X), delineated by the expression of myosin heavy chain isoforms (MYHs). However, whether discrete…
Darren M. Blackburn, Felicia Lazure, Theodore J. Perkins, Vahab D. Soleimani
Skeletal muscle is a heterogeneous tissue. Individual myofibers that make up the contractile muscle tissue exhibit variation in their metabolic and contractile properties. Although there are biochemical and histological assays to study myofiber heterogeneity, efficient methods to analyze the whole transcriptome of…
Douglas W Van Pelt, Yalda A Kharaz, Dylan C Sarver, Logan R Eckhardt + 6 more
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease characterized by extensive muscle weakness. Patients with DMD lack a functional dystrophin protein, which transmits force and organizes the cytoskeleton of skeletal muscle. Multiomic studies evaluate combined changes in the transcriptome…
Diana David-Rus
Age-related muscle decline, a condition referred to as sarcopenia and defined as loss in muscle mass and muscle strength over time, is one of the most pervasive problems of the elderly, such that significant declines in strength and mobility affects essentially every old person We have found that aging C. elegans body…
Diana David-Rus
My analysis uses methods developed for data mining microarray experiments, adapted for aging research. Methods bridge knowledge of statistical mechanics with data mining methods developed in statistical mathematics. Analyses can reveal how the transcriptional regulation of genes might coincide, thereby implicating…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Susumu Muroya
Skeletal muscle metabolism regulates homeostatic balance in animals. The metabolic impact persists even after farm animal skeletal muscle is converted to edible meat through postmortem rigor mortis and aging. Muscle metabolites resulting from animal growth and postmortem storage have a significant impact on meat…
Unmod Senapati, Barsha Priyadarshini Kar, Sunil Pani, Naresh Chandra Bal
Skeletal muscle undergo remarkable changes during aging including anatomical, ultrastructural, and moreover biochemical. The aging associated reduction of muscle mass, termed as sarcopenia, is a major factor in geriatric functional decline and frailty, contributing to the lowering of self-confidence. In an adult…
Atif Khan, Conor Lawless, Amy E. Vincent, Charlotte Warren + 3 more
'Valeria Di Leo' 'Tiago Gomes' 'A. Stephen McGough'] Single cell analysis of skeletal muscle (SM) tissue is a fundamental tool for understanding many neuromuscular disorders. For this analysis to be reliable and reproducible, identification of individual fibres within microscopy images (segmentation) of SM tissue…