15 papers · ranked by Valyu relevance
Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda, Marco Mangone
The body muscle is an important tissue used in organisms for proper viability and locomotion. The contractile unit of the muscle is the sarcomere, which is ultimately responsible for the contraction reaction leading to movement. Although this tissue is generally well studied and characterized, and many pathways have…
Tooba Abbassi-Daloii, Salma el Abdellaoui, Lenard M. Voortman, Thom Veeger + 7 more
Skeletal muscles support the stability and mobility of the skeleton but differ in biomechanical properties and physiological functions. The intrinsic factors that regulate muscle-specific characteristics are poorly understood. To study these, we constructed a large atlas of RNA-seq profiles from six leg muscles and two…
Jer-En Hsu, Lloyd Ruiz, Yongha Hwang, Steve Guzman + 10 more
Skeletal muscle is essential for both movement and metabolic processes, characterized by a complex and ordered structure. Despite its importance, a detailed spatial map of gene expression within muscle tissue has been challenging to achieve due to the limitations of existing technologies, which struggle to provide…
Anna L. Schorr, Alejandro Felix Mejia, Martina Y. Miranda, Marco Mangone
'Marco Mangone'] The body muscle is an important tissue used in organisms for proper viability and locomotion. Although this tissue is generally well studied and characterized, and many pathways have been elucidated throughout the years, we still lack a comprehensive understanding of its transcriptome and how it…
Kevin A. Murach, Charlotte A. Peterson
In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult skeletal muscle to reveal complex cell type-specific regulation of muscle plasticity. Expanding -omics technology at single cell resolution, complimented by advanced computational approaches, promise…
Tooba Abbassi-Daloii, Salma el Abdellaoui, Lenard M Voortman, Thom TJ Veeger + 9 more
'Thom TJ Veeger' 'Davy Cats' 'Hailiang Mei' 'Duncan E Meuffels' 'Ewoud van Arkel' "Peter AC 't Hoen" 'Hermien E Kan' 'Vered Raz' 'Christopher L-H Huang' 'Mone Zaidi'] Skeletal muscles support the stability and mobility of the skeleton but differ in biomechanical properties and physiological functions. The intrinsic…
Alix Simon, Sarah Djeddi, Pauline Bournon, David Reiss + 2 more
'Julie Thompson' 'Jocelyn Laporte'] Title: ABSTRACT Gene differential expression and alternative splicing are mechanisms that give rise to a plethora of tissue-specific transcripts. Although these mechanisms have been studied in various tissues, their role during muscle maturation is not well understood. Because this…
Roger Moreno-Justicia, Thibaux Van der Stede, Ben Stocks, Jenni Laitila + 18 more
Skeletal muscle is an inherently heterogenous tissue comprised primarily of myofibers, which are historically classified into three distinct fiber types in humans: one “slow” (type 1) and two “fast” (type 2A and type 2X), delineated by the expression of myosin heavy chain isoforms (MYHs). However, whether discrete…
Jonathan C. Mcleod, Changhyun Lim, Tanner Stokes, Jalil-Ahmad Sharif + 13 more
A majority of human genes produce non-protein-coding RNA (ncRNA), and some have roles in development and disease. Neither ncRNA nor human skeletal muscle is ideally studied using short-read sequencing, so we used a customised RNA pipeline and network modelling to study cell-type specific ncRNA responses during muscle…
Michael J. Stec, Zachary A. Graham, Qi Su, Christina Adler + 9 more
Chronic exercise training substantially improves skeletal muscle function and performance. The repeated demands and stressors of each exercise bout drive coordinated molecular adaptations within multiple cell types in muscle tissue, leading to enhanced neuromuscular recruitment and contractile function, stem cell…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Unmod Senapati, Barsha Priyadarshini Kar, Sunil Pani, Naresh Chandra Bal
Skeletal muscle undergo remarkable changes during aging including anatomical, ultrastructural, and moreover biochemical. The aging associated reduction of muscle mass, termed as sarcopenia, is a major factor in geriatric functional decline and frailty, contributing to the lowering of self-confidence. In an adult…
Susumu Muroya
Skeletal muscle metabolism regulates homeostatic balance in animals. The metabolic impact persists even after farm animal skeletal muscle is converted to edible meat through postmortem rigor mortis and aging. Muscle metabolites resulting from animal growth and postmortem storage have a significant impact on meat…
James Titus‐McQuillan, Adalena V. Nanni, Lauren M. McIntyre, Rebekah L. Rogers
'Rebekah L. Rogers'] Genomic complexity is a growing field of evolution, with case studies for comparative evolutionary analyses in model and emerging non-model systems. Understanding complexity and the functional components of the genome is an untapped wealth of knowledge ripe for exploration. With the "remarkable…
Atif Khan, Conor Lawless, Amy E. Vincent, Charlotte Warren + 3 more
'Valeria Di Leo' 'Tiago Gomes' 'A. Stephen McGough'] Single cell analysis of skeletal muscle (SM) tissue is a fundamental tool for understanding many neuromuscular disorders. For this analysis to be reliable and reproducible, identification of individual fibres within microscopy images (segmentation) of SM tissue…