25 papers · ranked by Valyu relevance
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz + 17 more
'Larry I. Benowitz' 'Adriana Di Polo' 'Cheryl Wellington' 'Jeffrey L. Goldberg' 'Zhigang He' 'Xin Duan' 'Guojun Bu' 'Albert A. Davis' 'Karthik Shekhar' 'Anna La Torre' 'David C. Chan' 'M. Valeria Canto-Soler' 'John G. Flanagan' 'Preeti Subramanian' 'Sharyn Rossi' 'Thomas Brunner' 'Diane E. Bovenkamp' 'David J.…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias…
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh + 10 more
'Neelam Sharma' 'Gokhan Zengin' 'Simona Bungau' 'Felicia Liana Andronie-Cioara' 'Mihai Alexandru Munteanu' 'Mihaela Cristina Brisc' 'Diana Uivarosan' 'Ciprian Brisc' 'Giuseppe Lazzarino' 'Anne Vejux'] The human body is highly complex and comprises a variety of living cells and extracellular material, which forms…
Elodie Kip, Louise C. Parr-Brownlie
Since the mid-20th century, Western societies have considered productivity and economic outcomes are more important than focusing on people’s health and wellbeing. This focus has created lifestyles with high stress levels, associated with overconsumption of unhealthy foods and little exercise, which negatively affect…
Marin Kuntić, Omar Hahad, Thomas Münzel, Andreas Daiber + 2 more
'Judit Marsillach' 'Ashley I. Bush'] Neurodegenerative diseases are often referred to as diseases of old age, and with the aging population, they are gaining scientific and medical interest. Environmental stressors, most notably traffic noise and air pollution, have recently come to the forefront, and have emerged as…
Vasileios Siokas, Efthimios Dardiotis
A multitude of diseases presenting a wide variety of phenotypic appearances are included in neurodegenerative disorders. They are mainly characterized by the loss of specific populations of neural cells. Moreover, several pathophysiological mechanisms can lead to neuronal dysfunction and death, and thus, to…
Shih-Ching Chou, Akanksha Aggarwal, Valina L Dawson, Ted M Dawson + 1 more
'Tae-In Kam'] The worldwide health-care burden of neurodegenerative diseases is on the rise-a crisis created through a combination of increased caseload and lack of effective treatments. The limitations of pharmacotherapy in these disorders have led to an urgent shift toward research and clinical trials for the…
Eli J. Cornblath, John L. Robinson, Virginia M.-Y. Lee, John Q. Trojanowski + 1 more
In current models of neurodegeneration, individual diseases are defined by the presence of one or two pathogenic protein species. Yet, it is the rule rather than the exception that a patient meets criteria for more than one disease. This fact often remains hidden until autopsy, when neuropathological evaluation can…
Christoffer G. Alexandersen, Georgia S. Brennan, Julia K. Brynildsen, Michael X. Henderson + 2 more
—Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our understanding of these processes, but efforts have traditionally focused on either neuronal dynamics or the underlying biological mechanisms of…
Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa
Neurodegenerative diseases affect a high percentage of older adults worldwide, and may become a public health issue. In the last century, the increase in the aging population has been accompanied by the development of neurodegenerative diseases characterized by dementia, cognitive impairment, and comorbidities with…
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar + 2 more
For over a century, brain research narrative has mainly centered on neuron cells. Accordingly, most whole-brain neurodegenerative studies focus on neuronal dysfunction and their selective vulnerability, while we lack comprehensive analyses of other major cell-types’ contribution. By unifying spatial gene expression…
Matthew J Leventhal, Camila A Zanella, Byunguk Kang, Jiajie Peng + 14 more
Despite years of intense investigation, the mechanisms underlying neuronal death in Alzheimer’s disease, the most common neurodegenerative disorder, remain incompletely understood. To define relevant pathways, we integrated the results of an unbiased, genome-scale forward genetic screen for age-associated…
Annalena Kenzelmann, Christina Boch, Ronny Schmidt, Mario Richter + 1 more
Neurodegenerative diseases are a major cause of morbidity and mortality world-wide, and their public health burden continues to increase. There is an urgent need to develop reliable and sensitive biomarkers to aid the timely diagnosis, disease progression monitoring, and therapeutic development for neurodegenerative…
Daisy Sproviero, Stella Gagliardi, Susanna Zucca, Maddalena Arigoni + 17 more
Identifying robust biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Melissa Grant-Peters, Aine Fairbrother-Browne, Amy Hicks, Boyi Guo + 10 more
Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk genes. We have investigated whether ligand-receptor interactions (LRIs) are a mechanism by which distinct genes associated with disease risk can impact overlapping outcomes. We found that…
Abdulahad Bayraktar, Tuğba Önal-Süzek, Barış Ethem Süzek, Ömür Baysal
Neurodegenerative diseases are defined as loss of structure and function of specific neural cell groups resulting in mortality. These diseases are mostly associated with aging, due to the high prevalence in elder age groups (Feigin et al., 2017). Although aging association has been shown experimentally to a degree…
Jessica Valero-Rojas, Camilo Ramírez, Laura Pacheco-Paternina, Paulina Valenzuela-Hormazabal + 5 more
Alzheimer’s disease (AD), a prevalent neurodegenerative disorder, presents significant challenges in drug development due to its multifactorial nature. The AlzyFinder Platform presented here addresses this by providing a comprehensive, free web-based tool for ligand-based virtual screening and network pharmacology…
Hina Shaheen, Roderick Melnik
Disorders: A Review Authors: ['Hina Shaheen' 'Roderick Melnik'] ABSTRACT It is essential to understand the complex structure of the human brain to develop new treatment approaches for neurodegenerative disorders (NDDs). This review paper comprehensively discusses the challenges associated with modelling the complex…
Jingwen Zhang, Defu Yang, Wei He, Guorong Wu + 1 more
Currently, many studies of Alzheimer's disease (AD) are investigating the neurobiological factors behind the acquisition of beta-amyloid (A), pathologic tau (T), and neurodegeneration ([N]) biomarkers from neuroimages. However, a system-level mechanism of how these neuropathological burdens promote neurodegeneration…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Wyatt Powell, Ruiheng Jing, Maciej Walczak
Deposits of the microtubule-associated protein tau (MAPT) serve as a hallmark of neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated that in diseases such as Alzheimer’s disease (AD), tau undergoes extensive remodeling. The attachment of post-translational modifications distributed…
Authors not listed
Caenorhabditis elegans (C. elegans) is a well-established nematode model for studying metabolism and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s disease (PD). Non-targeted metabolomics via liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has proven useful for uncovering…
Irina Kareva
Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse. We begin by tracing the historical merger of early- and…
Arnav Bhakta, Carolyn Byrne
Creutzfeldt-Jakob disease (CJD) is a rapidly progressive and fatal neurodegenerative disease, that causes approximately 350 deaths in the United States every year. In specific, it is a prion disease that is caused by a misfolded prion protein, termed PrPSc, which is the infectious form of the prion protein PrPC. Rather…