28 papers · ranked by Valyu relevance
Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias + 3 more
Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and Huntington’s disease represent a major challenge in neuroscience due to their complex, multifactorial nature and the absence of curative treatments. These disorders share common molecular mechanisms, including oxidative…
Federico Zoila, Maria Ida de Stefano, Alessia Sgobbio, Maria Antonietta Panaro + 9 more
Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent a growing global health concern with no definitive cure. Increasing evidence suggests that mind-body practices like yoga may offer neuroprotective benefits by modulating stress, neuroinflammation, and…
Alexander Muacevic, John R Adler, Julia P Bethea, Hasin Sharma + 10 more
Neurodegenerative diseases are comprised of a host of chronic conditions that impair the central nervous system. Osteopathic manipulative treatment (OMT) consists of many non-invasive modalities that can be used to treat a wide variety of ailments and conditions. OMT is reported to increase the range of motion and…
Alyssa Ealy, Amanda M. Serapiglia, Nikhil Panicker
Neurodegenerative diseases are characterized by the dysfunction and death of susceptible neuronal populations. Increasing evidence has demonstrated that sustained neuroinflammation and activation of innate immune complexes underlie neurodegeneration, worsening disease progression and outcomes. Sterile inflammation…
She, Xutong
Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review synthesizes the evolving understanding of AD pathogenesis, moving beyond the linear…
Deboral Eshak, Mohanapriya Arumugam
The World Health Organization (WHO) has identified neurological disorders (NDs) as one of the major health concerns worldwide, resulting in high mortality rates. NDs are conditions affecting the central and peripheral nervous systems, including the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots…
Ana Margarida Salgueiro, Marisa Ferreira-Marques, Rodrigo F. N. Ribeiro, Sara M. Lopes + 5 more
The ketogenic diet (KD) is increasingly recognized as a promising therapeutic strategy for neurodegenerative disorders because of its multifaceted impacts on key pathophysiological mechanisms. This review explores the molecular pathways through which KD may protect against neurodegeneration, including the use of ketone…
Zitin Wali, Neha, Moyad Shahwan, Khuzin Dinislam + 3 more
The most persistent biomedical challenges of the 21st century are neurodegenerative disorders (NDs), where molecular alterations lead to devastating clinical consequences and progressive neuronal loss. The prevalence of neurodegeneration is continuously rising and becoming the main contributor to chronic disability and…
Xue Jiang, Dongqing Wei, Jing Ye, Eric Gilson
Alzheimer’s disease (AD) is a most common age-related neurodegenerative disease with no effective treatments, is one of the leading contributions to global disease burden. AD is represented by complicated biological mechanisms and complexity of brain tissues, often manifested histologically by the parenchymal…
Qian Hu, Jiasheng Wang, Ruiyang Cao, Wenkai Liu + 1 more
Neurodegenerative diseases are a group of chronic, progressive neurological disorders caused by the degeneration and functional loss of neurons and glial cells, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD). Although numerous treatments are available for these diseases…
Ramkumar Balaji, Himanshu Joshi, Basant K Patel
Aberrant mitochondrial localization of the RNA/DNA-binding protein TDP-43 is implicated in amyotrophic lateral sclerosis (ALS) which may affect mitochondrial dynamics and contribute to neuronal toxicity. Inhibitors of the cytoplasmic aggregation of TDP-43 were reported previously, but their effect on the mitochondrial…
Krishnakumar Vaithianathan
Neurodegenerative disorders such as Alzheimer's disease exhibit highly organized patterns of regional brain vulnerability, yet the biological mechanisms underlying this spatial selectivity remain incompletely understood. Existing imaging-transcriptomic studies have largely relied on correlation-based analyses between…
Pablo Miaja, Marcos Martinez-Baños, María Jesús Martin-Bermejo, Inmaculada Moreno + 2 more
Alzheimer’s disease (AD) is characterized by early synaptic dysfunction followed by progressive amyloid-β (Aβ) accumulation, neuroinflammation, and cognitive decline. We previously identified Secreted Frizzled-Related Protein 1 (SFRP1) as a multifactorial contributor to AD pathogenesis and provided initial evidence…
Katherine Fodder, Megha Murthy, Joshua Harvey, Ehsan Pishva + 6 more
Myelin associated oligodendrocyte basic protein (MOBP) is an abundantly expressed oligodendrocyte gene. Genetic variation at the MOBP locus has been associated with risk for multiple neurodegenerative disorders, including progressive supranuclear palsy (PSP), amyotrophic lateral sclerosis (ALS), and frontotemporal…
Authors not listed
The amyloid-β (Aβ) peptides are crucial biomarkers for the diagnosis of Alzheimer's disease (AD), the most common neurodegenerative disease. The high diversity of the Aβ family provides a significant challenge for recognizing various Aβ forms, which may differ by a single amino acid or a post-translational…
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic Ibarra Javonillo + 11 more
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. It is characterized by cognitive decline and accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles. Accumulating evidence indicates that viral infection may worsen and/or increase development of…
Patrycja M. Forster, Oliver Bracko, Ruslan Rust
The blood-brain barrier (BBB) plays a central role in brain function and is increasingly implicated in neurodegenerative disease. Major neurodegenerative disorders, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), and Huntington’s disease (HD), share overlapping pathological features. Yet, the extent…
Nehal Adel Abdelsalam, Muhammad Elsadany, Eman Badr
Neurodegenerative diseases are a major threat to older adults and represent a growing global health burden as the elderly population continues to expand. The complexity of neurodegenerative diseases and the incomplete understanding of their pathophysiology limit the development of effective therapeutics. To study…
Authors not listed
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and widespread neurovascular disturbances. Traditional fMRI provides valuable spatial maps of blood-oxygen-level-dependent (BOLD) changes but often lacks the capacity to quantify the interplay of cerebral blood flow…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…
Authors not listed
The de novo total synthesis of position-selectively glycosylated aggregation-prone proteins has established the importance of posttranslational glycosylation in suppressing aggregation and reducing cytotoxicity. Here, building on our strategy of disrupting intermolecular interactions, we focused on tyrosine carbon as a…
Authors not listed
Current methods for determining the neurotoxic potential of (agro)chemicals are not comprehensive enough, as is suggested by the increased incidence of Parkinson’s disease (PD) amongst people exposed to certain pesticides. Mechanism-based in silico screening can address this shortcoming by predicting molecular…
Authors not listed
Alzheimer's disease (AD) is a neurodegenerative disorder caused by multiple factors that require the development of multi-target directed ligands (MTDL) to treat its pathophysiology. Using Hyperoside, a major Himalayan plant extract, this study will report on the potential use of this compound as a therapeutic agent…
Vishaak Gangasandra, Finn Blain, Elise Delzant, Michelle Lupton + 3 more
INTRODUCTION. This study presents the first quantification of vertex-level grey-matter associations between Alzheimer's disease (AD) and Parkinson's disease (PD) using highresolution brain maps aggregated from large MRI datasets. The aim is to identify shared neuroanatomical signatures between the two diseases.…
Authors not listed
The intricate bidirectional communication between mitochondria and the gut microbiota – termed mitochondria-microbiome crosstalk – plays a pivotal role in regulating host metabolism, immune responses, and overall physiological homeostasis. Emerging evidence highlights how microbial-derived metabolites, such as…
Malinda Iluppangama, Dilmi Abeywardana
Background: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established PD treatment that improves motor symptoms and quality of life, but long-term survival and mortality risk remain poorly characterized. This study evaluated long-term survival and mortality-associated factors after STN-DBS. Methods…
Daniel Hegedus, Marton Barnabas Mora, Balint Varga, Vince Grolmusz
With the enormous advances in cerebral imaging techniques, a large amount of data is available for studying the aging and demented brain. In this contribution, we apply the OASIS-3 dataset for identifying small areas of the human gray matter, which have higher- or lower structural connectivity in dementia and aging. As…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…