25 papers · ranked by Valyu relevance
Stephen D. Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often…
Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress…
A. Bersano, J. Engele, M.K.E. Schäfer
Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory…
She, Xutong
Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review synthesizes the evolving understanding of AD pathogenesis, moving beyond the linear…
Yejia Xu, Bowen Jia, Jing Li, Qianqian Li + 2 more
'Pamela A. Maher'] Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain diseases, traumatic brain injury, epilepsy, depression, and more. The involved pathogenesis is notably…
She Xutong
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. It is characterized by various pathological markers in the brain——large numbers ofamyloid plaques surrounded by neurons containing neurofibrillary tangles, vascular damage from extensive plaque…
Emmanuel Moyse, Slavica Krantic, Nesrine Djellouli, Sébastien Roger + 5 more
'Denis Angoulvant' 'Camille Debacq' 'Victoire Leroy' 'Bertrand Fougere' 'Amal Aidoud'] Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm’aging. Neuroinflammation is…
Mario García-Domínguez, Wenqiang Fan
Neuroinflammation represents a fundamental component in the development and progression of a wide range of neurological disorders, including neurodegenerative diseases, psychiatric conditions, and cerebral injuries. This review examines the complex mechanisms underlying neuroinflammatory responses, with a focus on the…
Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini + 10 more
'Adriano Cressoni Araújo' 'Karina Torres Pomini' 'Cristiano Machado Galhardi' 'Claudia Rucco Penteado Detregiachi' 'Luíza Santos de Argollo Haber' 'Domingos Donizeti Roque' 'Marcelo Dib Bechara' 'Marcela Vialogo Marques de Castro' 'Eliana de Souza Bastos Mazuqueli Pereira' 'Ricardo José Tofano' 'Iris Jasmin Santos…
Vandana Blossom, Sheetal D. Ullal, Melisha M. D’Souza, Anu V. Ranade + 2 more
'Nayanatara A. Kumar' 'Rajalakshmi Rai'] Neuroinflammation is known to be a contributing factor for several neurological disorders as well as cognitive dysfunction. Different signalling pathways, and a variety of supporting cells of CNS are suggested to be involved in the progression of neurodegeneration. Among the…
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia + 4 more
Acute activation of innate immune response in the brain, or neuroinflammation, protects this vital organ from a range of external pathogens and promotes healing after traumatic brain injury. However, chronic neuroinflammation leads to the activation of immune cells like microglia and astrocytes causes damage to the…
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall + 10 more
It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential of diffusion MRI (dMRI) to characterize changes in microglial density and morphology associated with neuroinflammation, but these were…
Hongwei Cai, Zheng Ao, Liya Hu, Younghye Moon + 4 more
Neuroinflammation plays a central role in the progression of many neurodegenerative diseases such as Alzheimer’s disease, and challenges remain in modeling the complex pathological or physiological processes. Here, we report an acoustofluidic 3D cell culture device that can rapidly construct 3D neurospheroids and…
Fan Li, Jazlyn Gallego, Natasha N Tirko, Jenna Greaser + 12 more
Microglia are important players in surveillance and repair of the brain. Their activation mediates neuroinflammation caused by intracortical microelectrode implantation, which impedes the application of intracortical brain-computer interfaces (BCIs). While low-intensity pulsed ultrasound stimulation (LIPUS) can…
Blanca Diaz-Castro, Alexander M. Bernstein, Giovanni Coppola, Michael V. Sofroniew + 1 more
Astrocytes are widely implicated in CNS diseases, but their contributions to disease related phenotypes remain incompletely explored. Anhedonia accompanies several neurological and psychiatric diseases, including major depressive disorder (MDD) and Alzheimer’s disease (AD), both of which are associated with…
Sahil Threja, Nathan Ryzewski Strogulski, Janeen Laabei, Gloria Vegliante + 9 more
Traumatic brain injury (TBI) initiates a rapidly evolving neuroinflammatory response; however, the temporal relationship between early innate immune activation, T cell polarization, and neurobehavioural recovery remains poorly understood. Here, we hypothesize that interleukin-1β (IL-1β) is a critical upstream mediator…
Paula Desplats, Ashley Gutierrez, Marta C. Antonelli, Martin G. Frasch
'Martin G. Frasch'] We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic…
Sara Amato, Andrea Arnold
Neural inflammation immediately follows the onset of ischemic stroke. During this process, microglial cells can be activated into two different phenotypes: the M1 phenotype, which can worsen brain injury by producing pro-inflammatory cytokines; or the M2 phenotype, which can aid in long term recovery by producing…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…
Marc Courchesne, Colin Wakefield, Karen Nygard, Patrick Burns + 4 more
'Gilles Fecteau' 'André Desrochers' 'Mingju Cao' 'Martin G. Frasch'] Biotron, Western University, London, ON, Canada Department of Biology, Western University, London, ON, Canada Drexel University College of Medicine, Philadelphia, PA, USA Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Université de…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Hao Yan, Xiangyang Cao, Meng Ma, Qianxiong He + 6 more
Ischemic stroke is a leading cause of disability and mortality, with neuroinflammation playing a key role in post-stroke injury. The molecular mechanisms remain incompletely defined. This study explored the functions of IRF7 and its downstream target ISG15 in stroke-associated neuroinflammation and prognosis of…
Authors not listed
Fluoroquinolones are recognized widely for their efficacies against bacterial infection, as they are mainly associated with QT interval prolongation due to the inhibition of the hERG potassium channels. Although repurposing of drug development offers cost-effective therapeutic opportunities, the mechanistic role of…
Jessica Valero-Rojas, Camilo Ramírez, Laura Pacheco-Paternina, Paulina Valenzuela-Hormazabal + 5 more
Alzheimer’s disease (AD), a prevalent neurodegenerative disorder, presents significant challenges in drug development due to its multifactorial nature. The AlzyFinder Platform presented here addresses this by providing a comprehensive, free web-based tool for ligand-based virtual screening and network pharmacology…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…