18 papers · ranked by Valyu relevance
Chang Liu, Alfredo Cardenas-Rivera, Shayna Teitelbaum, Austin Birmingham + 2 more
Neuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD). Numerous studies have asserted a close association between neuroinflammation and disrupted cerebral energetics. During AD progression and other neurodegenerative disorders, a persistent…
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia + 4 more
Acute activation of innate immune response in the brain, or neuroinflammation, protects this vital organ from a range of external pathogens and promotes healing after traumatic brain injury. However, chronic neuroinflammation leads to the activation of immune cells like microglia and astrocytes causes damage to the…
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall + 10 more
It is becoming increasingly apparent that neuroinflammation plays a critical role in an array of neurological and psychiatric disorders. Recent studies have demonstrated the potential of diffusion MRI (dMRI) to characterize changes in microglial density and morphology associated with neuroinflammation, but these were…
Hongwei Cai, Zheng Ao, Liya Hu, Younghye Moon + 4 more
Neuroinflammation plays a central role in the progression of many neurodegenerative diseases such as Alzheimer’s disease, and challenges remain in modeling the complex pathological or physiological processes. Here, we report an acoustofluidic 3D cell culture device that can rapidly construct 3D neurospheroids and…
I. Pediaditakis, K. R. Kodella, D. V. Manatakis, C. Y. Le + 8 more
Species differences in the brain and the blood-brain barrier (BBB) biology hamper the translation from animal models to humans and impede the development of specific therapeutics for brain diseases. Here we present a human Brain-Chip engineered to recapitulate critical aspects of the complex brain cell-cell…
Md Shamim Hossain, Shalman Dipto, Honsho Masanori, Tatsuo Okauchi + 2 more
Neuroinflammation is a key driver of neurodegenerative disorders, with chronic activation of the NF-κB pathway contributing to neuronal dysfunction and disease progression. In this study, we report that KIT-8, a synthetic alkyl ether lipid, exerts potent anti-inflammatory and neuroprotective effects despite its…
Fan Li, Jazlyn Gallego, Natasha N Tirko, Jenna Greaser + 12 more
Microglia are important players in surveillance and repair of the brain. Their activation mediates neuroinflammation caused by intracortical microelectrode implantation, which impedes the application of intracortical brain-computer interfaces (BCIs). While low-intensity pulsed ultrasound stimulation (LIPUS) can…
Isha Mhatre-Winters, Aseel Eid, Nicole Blum, Yoonhee Han + 3 more
Alzheimer’s disease (AD) is characterized by the presence of amyloid-β plaques, neurofibrillary tangles, and neuroinflammation. Previously, we reported serum levels of dichlorodiphenyldichloroethylene (DDE), the primary metabolite of the pesticide dichlorodiphenyltrichloroethane (DDT), were significantly higher in AD…
Blanca Diaz-Castro, Alexander M. Bernstein, Giovanni Coppola, Michael V. Sofroniew + 1 more
Astrocytes are widely implicated in CNS diseases, but their contributions to disease related phenotypes remain incompletely explored. Anhedonia accompanies several neurological and psychiatric diseases, including major depressive disorder (MDD) and Alzheimer’s disease (AD), both of which are associated with…
Claire L Davies, Anirudh Patir, Barry W McColl
Inflammation contributes to tissue repair and restoration of function after infection or injury. However, some forms of inflammation can cause tissue damage and disease, particularly if inappropriately activated, excessive, or not resolved adequately. The mechanisms that prevent excessive or chronic inflammation are…
Sahil Threja, Nathan Ryzewski Strogulski, Janeen Laabei, Gloria Vegliante + 9 more
Traumatic brain injury (TBI) initiates a rapidly evolving neuroinflammatory response; however, the temporal relationship between early innate immune activation, T cell polarization, and neurobehavioural recovery remains poorly understood. Here, we hypothesize that interleukin-1β (IL-1β) is a critical upstream mediator…
Gaia Brezzo, Julie Simpson, Kamar E. Ameen-Ali, Jason Berwick + 1 more
Brain health relies on a tightly regulated system known as neurovascular function whereby the cellular constituents of the neurovascular unit (NVU) regulate cerebral haemodynamics in accordance with neuronal metabolic demand. Disruption of neurovascular function impairs brain health and is associated with the…
Mario Villa-González, Marina Rubio, Gerardo Martín-López, Paula R Mallavibarrena + 4 more
Ischemic stroke is a sudden and acute disease characterized by neuronal death, glia activation, and a severe inflammatory process. Neuroinflammation is an early event after cerebral ischemia, with microglia playing a leading role. Microglial activation involves functional and morphological changes that drive a wide…
Changming Liu, Bingrui Zhu, Yuchun Liu, Qian Yu + 10 more
Subarachnoid hemorrhage (SAH) triggers a complex immune response that critically influences early brain injury (EBI) and long-term outcomes. However, the precise spatiotemporal dynamics and heterogeneity of immune cell infiltration and microglial reprogramming remain poorly understood. We aimed to construct a…
Sergio Castro-Gomez, Ana Vieira-Saecker, Juan Ignacio Muñoz-Manco, Tao Li + 7 more
NLRP3 plays an essential role in secondary neuroinflammatory damage following traumatic brain injury (TBI). However, the specific mechanisms mediating NLRP3’s effects in TBI remain poorly understood, and it is unknown whether its pharmacological inhibition with oral compounds during initial phases confers long-term…
Hao Yan, Xiangyang Cao, Meng Ma, Qianxiong He + 6 more
Ischemic stroke is a leading cause of disability and mortality, with neuroinflammation playing a key role in post-stroke injury. The molecular mechanisms remain incompletely defined. This study explored the functions of IRF7 and its downstream target ISG15 in stroke-associated neuroinflammation and prognosis of…
Alejandra Palomino-Antolin, Paloma Narros-Fernández, Víctor Farré-Alins, Javier Sevilla-Montero + 7 more
Post-ischemic inflammation contributes to worsening of ischemic brain injury and in this process, the inflammasomes play a key role. Inflammasomes are cytosolic multiprotein complexes which upon assembly activate the maturation and secretion of the inflammatory cytokines IL-1β and IL-18. However, participation of the…
Aminata P. Coulibaly, Pinar Pezuk, William Gartman, Danielle Triebwasser + 1 more
Neutrophil infiltration into the central nervous system (CNS) after aneurysmal subarachnoid hemorrhage (SAH) is critical to the development of delayed cerebral injury (DCI). The goal of the present study is to characterize the neutrophil activity that leads to DCI. We tested mice deficient in elastase, NADPH oxidase…