16 papers · ranked by Valyu relevance
Stephen D. Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often…
Yuanjie Sun, Yoshihisa Koyama, Shoichi Shimada
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress…
Manoj Banjara, Chaitali Ghosh
Sterile neuroinflammation is essential for the proper brain development and tissue repair. However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes. The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that…
Alexander Muacevic, John R Adler, Zahieh Suleiman Khoury, Fatima Sohail + 8 more
'Fatima Sohail' 'Jada Wang' 'Moises Mendoza' 'Mohammed Raake' 'Mohammed Tahoor Silat' 'Manoj Reddy Bathinapatta' 'Amirali Sadeghzadegan' 'Patel Meghana' 'Janisha Paul'] This review offers a comprehensive review of the signals and the paramount role neuroinflammation plays in neurodegenerative diseases such as…
A. Bersano, J. Engele, M.K.E. Schäfer
Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory…
Yejia Xu, Bowen Jia, Jing Li, Qianqian Li + 2 more
'Pamela A. Maher'] Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain diseases, traumatic brain injury, epilepsy, depression, and more. The involved pathogenesis is notably…
Mi Eun Kim, Jun Sik Lee, Wenqiang Fan
Neuroinflammation is a complex and dynamic response of the central nervous system (CNS) to injury, infection, and disease. While acute neuroinflammation plays a protective role by facilitating pathogen clearance and tissue repair, chronic and dysregulated inflammation contributes significantly to the progression of…
Morena Zusso, Leanne Stokes, Stefano Moro, Pietro Giusti
Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric disorders (e.g., Alzheimer's disease, AD; Parkinson's disease, PD…
Emmanuel Moyse, Slavica Krantic, Nesrine Djellouli, Sébastien Roger + 5 more
'Denis Angoulvant' 'Camille Debacq' 'Victoire Leroy' 'Bertrand Fougere' 'Amal Aidoud'] Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm’aging. Neuroinflammation is…
Ali Gorji
Neuroinflammation is implicated in the pathophysiology of several neurological diseases. The key role of neuroinflammation in a wide range of neurological disorders makes it highly attractive for diagnostic examinations and therapeutic interventions in recent years [1]. The objective of this Special Issue is to collect…
Mario García-Domínguez, Wenqiang Fan
Neuroinflammation represents a fundamental component in the development and progression of a wide range of neurological disorders, including neurodegenerative diseases, psychiatric conditions, and cerebral injuries. This review examines the complex mechanisms underlying neuroinflammatory responses, with a focus on the…
Lucas Fornari Laurindo, Jefferson Aparecido Dias, Adriano Cressoni Araújo, Karina Torres Pomini + 10 more
'Adriano Cressoni Araújo' 'Karina Torres Pomini' 'Cristiano Machado Galhardi' 'Claudia Rucco Penteado Detregiachi' 'Luíza Santos de Argollo Haber' 'Domingos Donizeti Roque' 'Marcelo Dib Bechara' 'Marcela Vialogo Marques de Castro' 'Eliana de Souza Bastos Mazuqueli Pereira' 'Ricardo José Tofano' 'Iris Jasmin Santos…
Vandana Blossom, Sheetal D. Ullal, Melisha M. D’Souza, Anu V. Ranade + 2 more
'Nayanatara A. Kumar' 'Rajalakshmi Rai'] Neuroinflammation is known to be a contributing factor for several neurological disorders as well as cognitive dysfunction. Different signalling pathways, and a variety of supporting cells of CNS are suggested to be involved in the progression of neurodegeneration. Among the…
Ludmila Müller, Svetlana Di Benedetto, Viktor Müller
Neuroinflammation is a dynamic, context-sensitive process that plays essential roles in brain development, maintenance, and response to injury. It reflects a finely balanced neuroimmune state-facilitating repair and adaptation under homeostatic conditions, while also contributing to dysfunction when dysregulated or…
Sarosh R Irani, Avindra Nath, Frauke Zipp
Neuroinflammation is a rapidly evolving field with the realization that inflammatory cascades play an important role in the pathogenesis of several neurological diseases. However, the inflammatory response is complex and the cell types and signalling pathways involved may be disease-specific. Further, neuroinflammation…
Junhui Wang, Hongxing Wang, Dirk M. Hermann
Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a major and growing global health challenge. These disorders are characterized by the progressive loss of neuronal structure and function within…