25 papers · ranked by Valyu relevance
Lav R. Varshney, Beth L. Chen, Eric Paniagua, David H. Hall + 2 more
Despite recent interest in reconstructing neuronal networks, complete wiring diagrams on the level of individual synapses remain scarce and the insights into function they can provide remain unclear. Even for Caenorhabditis elegans, whose neuronal network is relatively small and stereotypical from animal to animal…
Mark D. Humphries
Systems neuroscience is in a headlong rush to record from as many neurons at the same time as possible. As the brain computes and codes using neuron populations, it is hoped these data will uncover the fundamentals of neural computation. But with hundreds, thousands, or more simultaneously recorded neurons come the…
Mark D. Humphries
Systems neuroscience is in a head-long rush to record from as many neurons at the same time as possible. As the brain computes and codes using neuron populations, it is hoped these data will uncover the fundamentals of neural computation. But with hundreds, thousands, or more simultaneously recorded neurons comes the…
Daniele Poli, Vito P. Pastore, Paolo Massobrio
Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental…
Johanna Senk, Birgit Kriener, Mikael Djurfeldt, Nicole Voges + 7 more
'Han-Jia Jiang' 'Lisa Schüttler' 'Gabriele Gramelsberger' 'Markus Diesmann' 'Hans E. Plesser' 'Sacha J. van Albada' 'Roberto Toro'] Sustainable research on computational models of neuronal networks requires published models to be understandable, reproducible, and extendable. Missing details or ambiguities about…
Przemyslaw Nowak, Paolo Massobrio, Sergio Martinoia
Computational capabilities of the brain emerge from the activity of large networks of neurons. Consequently, to better understand how the brain processes information, the relationship between neuronal network behavior and various network characteristics needs to be determined. Such an investigation, however, may be too…
June Hoan Kim, Jae Ryun Ryu, Boram Lee, Uikyu Chae + 4 more
'Bae Ho Park' 'Il-Joo Cho' 'Woong Sun'] The function of a neural circuit can be determined by the following: (1) characteristics of individual neurons composing the circuit, (2) their distinct connection structure, and (3) their neural circuit activity. However, prior research on correlations between these three…
Michael W. Reimann, Daniela Egas-Santander
Neuronal connectivity has been characterized at various scales and with respect to various structural aspects. In models of connectivity, it has so far remained difficult to match all of them at once, in particular the higher-order structure appears to be elusive. Here we introduce a new type of graph model that…
Antonio G. Zippo, Riccardo Storchi, Giuliana Gelsomino, Sara Nencini + 3 more
'Gian Carlo Caramenti' 'Maurizio Valente' 'Gabriele E. M. Biella'] Small-World Networks (SWNs) represent a fundamental model for the comprehension of many complex man-made and biological networks. In the central nervous system, SWN models have been shown to fit well both anatomical and functional maps at the…
Marina Vegué, Rodrigo Perin, Alex Roxin
The structure in cortical micro-circuits deviates from what would be expected in a purely random network, which has been seen as evidence of clustering. To address this issue we sought to reproduce the non-random features of cortical circuits by considering several distinct classes of network topology, including…
Stefano De Blasi
Understanding the complexity of biological neural networks like the human brain is one of the scientific challenges of our century. The organization of the brain can be described at different levels, ranging from small neural networks to entire brain regions. Existing methods for the description of functionally or…
Stefano De Blasi
- This work was done wholly or mainly while in candidature for a research degree at the University of Applied Sciences (UAS) Aschaffenburg. - Where any part of this report has previously been submitted for a degree at the UAS Aschaffenburg, this has been clearly stated. - Where I have consulted the published work of…
Julian M. L. Budd, Zoltán F. Kisvárday
In cerebral cortex, the huge mass of axonal wiring that carries information between near and distant neurons is thought to provide the neural substrate for cognitive and perceptual function. The goal of mapping the connectivity of cortical axons at different spatial scales, the cortical connectome, is to trace the…
Richard Betzel, Maria Grazia Puxeddu, Caio Seguin
One of the longstanding aims of network neuroscience is to link a connectome’s topological properties–i.e. features defined from connectivity alone–with an organism’s neurobiology. One approach for doing so is to compare connectome properties with maps of metabolic, functional, and neurochemical annotations. This type…
Betzel, Richard, Seguin, Caio + 2 more
Richard F. Betzel1, 2 , ∗ Caio Seguin 3 , and Maria Grazia Puxeddu 4 1 - Department of Neuroscience, University of Minnesota, Minneapolis MN 55419 2 - Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis MN 55413 3 - Department of Psychiatry, University of Melbourne, Melbourne AUS and 4 -…
Danielle S. Bassett, Perry Zurn, Joshua I. Gold
From interacting cellular components to networks of neurons and neural systems, interconnected units comprise a fundamental organizing principle of the nervous system. Understanding how their patterns of connections and interactions give rise to the many functions of the nervous system is a primary goal of…
Christian Donner, Julian Bartram, Philipp Hornauer, Taehoon Kim + 4 more
Probing the architecture of neuronal circuits and the principles that underlie their functional organization remains an important challenge of modern neurosciences. This holds true, in particular, for the inference of neuronal connectivity from large-scale extracellular recordings. Despite the popularity of this…
Rodrigo Muñoz-Castañeda, Brian Zingg, Katherine S. Matho, Quanxin Wang + 78 more
An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits and systems can be integrated and interpreted. Here, through a collaborative effort from the Brain Initiative Cell…
Marius Buibas, Gabriel A. Silva
Cellular neural circuit and networks consisting of interconnected neurons and glia are ultimately responsible for the information processing associated with information processing in the brain. While there are major efforts aimed at mapping the structural and (electro)physiological connectivity of brain networks, such…
Nathan Frey, Ryan Soklaski, Simon Axelrod, Siddharth Samsi + 3 more
Massive scale, both in terms of data availability and computation, enables significant breakthroughs in key application areas of deep learning such as natural language processing (NLP) and computer vision. There is emerging evidence that scale may be a key ingredient in scientific deep learning, but the importance of…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…