24 papers · ranked by Valyu relevance
Daniel Keller, Csaba Erö, Henry Markram
The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure when attempting to understand a brain. The synthesized…
Chih-Hsu Huang, Chou-Ching K. Lin
Nowadays, building low-dimensional mean-field models of neuronal populations is still a critical issue in the computational neuroscience community, because their derivation is difficult for realistic networks of neurons with conductance-based interactions and spike-frequency adaptation that generate nonlinear…
Valentin Schmutz, Eva Löcherbach, Tilo Schwalger
Population equations for infinitely large networks of spiking neurons have a long tradition in theoretical neuroscience. In this work, we analyze a recent generalization of these equations to populations of finite size, which takes the form of a nonlinear stochastic integral equation. We prove that, in the case of…
Tilo Schwalger, Anton V. Chizhov
- Generalized integrate-and-fire (GIF) models permit efficient extraction of point neuron parameters, which reproduce the spiking behavior of multiple cell types and are available from a public database. - Populations of GIF or conductance-based neuron models can be described by a single state variable – the "time…
Tilo Schwalger, Moritz Deger, Wulfram Gerstner
Neural population equations such as neural mass or field models are widely used to study brain activity on a large scale. However, the relation of these models to the properties of single neurons is unclear. Here we derive an equation for several interacting populations at the mesoscopic scale starting from a…
Thomas Jungas, Mathieu Joseph, Mohamad-Ali Fawal, Alice Davy
The mammalian neocortex is composed of different subtypes of projection neurons that are generated sequentially during embryogenesis by differentiation of neural progenitors. While molecular mechanisms that control neuronal production in the developing neocortex have been extensively studied, the dynamics and absolute…
Thomas Jungas, Mathieu Joseph, Mohamad-Ali Fawal, Alice Davy
The mammalian neocortex is composed of different subtypes of neurons which are generated during embryogenesis by sequential differentiation of neural progenitors. While molecular mechanisms that control neuronal production in the developing neocortex have been extensively studied, the dynamics and absolute numbers of…
Csaba Erö, Marc-Oliver Gewaltig, Daniel Keller, Henry Markram
Despite vast numbers of studies of stained cells in the mouse brain, no current brain atlas provides region-by-region neuron counts. In fact, neuron numbers are only available for about 4% of brain of regions and estimates often vary by as much as 3-fold. Here we provide a first 3D cell atlas for the whole mouse brain…
Katiele V. P. Brito, Fernanda S. Matias
Several experiments and models have highlighted the importance of neuronal heterogeneity in brain dynamics and function. However, how such a cell-to-cell diversity can affect cortical computation, synchronization, and neuronal communication is still under debate. Previous studies have focused on the effect of neuronal…
Sean R. Bittner, Ryan C. Williamson, Adam C. Snyder, Ashok Litwin-Kumar + 5 more
'Ashok Litwin-Kumar' 'Brent Doiron' 'Steven M. Chase' 'Matthew A. Smith' 'Byron M. Yu' 'Konrad P. Kording'] Many studies use population analysis approaches, such as dimensionality reduction, to characterize the activity of large groups of neurons. To date, these methods have treated each neuron equally, without taking…
Sarojini M. Attili, Keivan Moradi, Diek W. Wheeler, Giorgio A. Ascoli
Quantifying the population sizes of distinct neuron types in different anatomical regions is an essential step towards establishing a brain cell census. Although estimates exist for the total neuronal populations in different species, the number and definition of each specific neuron type are still intensively…
Bruno Mota, Suzana Herculano-Houzel
How does the size of the glial and neuronal cells that compose brain tissue vary across brain structures and species? Our previous studies indicate that average neuronal size is highly variable, while average glial cell size is more constant. Measuring whole cell sizes in vivo, however, is a daunting task. Here we use…
Mi Lu, Trung Le, Tianxing He, Eli Shlizerman + 1 more
Neurons can display highly variable dynamics. While such variability presumably supports the wide range of behaviors generated by the organism, their gene expressions are relatively stable in the adult brain. This suggests that neuronal activity is a combination of its time-invariant identity and the inputs the neuron…
Hao Si, Xiaojuan Sun
Neural coding is a key problem in neuroscience, which can promote people's understanding of the mechanism that brain processes information. Among the classical theories of neural coding, the population rate coding has been studied widely in many works. Most computational studies considered the neurons and the…
Lara Eid, Martin Parent
In the abstract, one should read ≪ Estimation of the neuronal population in the GPe (3.47 ± 0.15 × 103 neurons/mm3) and GPi (2.69 ± 0.18 × 103) ≫ instead of ≪ Estimation of the neuronal population in the GPe (3.47 ± 0.15 × 103 neurons/mm3) and GPi (2.69±0.18 × 106) ≫. Original article has been updated. Conflict of…
Li Yao, Hui Xu
This paper studies a stochastic neural field model that is extended from our previous paper [14]. The neural field model consists of many heterogeneous local populations of neurons. Rigorous results on the stochastic stability are proved, which further imply the well-definedness of quantities including mean firing rate…
Stefano Luccioli, Eshel Ben‐Jacob, Ari Barzilai, P. Bonifazi + 1 more
'Alessandro Torcini'] It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in…
Wei Jiao, Gard Spreemann, Evelyne Ruchti, Soumya Banerjee + 5 more
Establishing with precision the quantity and identity of the cell types of the brain is a prerequisite for a detailed compendium of gene and protein expression in the central nervous system. Currently however, strict quantitation of cell numbers has been achieved only for the nervous system of C.elegans. Here we…
S. Luccioli, A. Barzilai, E. Ben-Jacob, P. Bonifazi + 1 more
We consider a sparse random network of excitatory leaky integrate-andfire neurons with short-term synaptic depression. Furthermore to mimic the dynamics of a brain circuit in its first stages of development we introduce for each neuron correlations among in-degree and out-degree as well as among excitability and the…
Manfred J. Oswald, Malinda L. S. Tantirigama, Ivo Sonntag, Stephanie M. Hughes + 1 more
'Stephanie M. Hughes' 'Ruth M. Empson'] In the primary motor cortex (M1), layer 5 projection neurons signal directly to distant motor structures to drive movement. Despite their pivotal position and acknowledged diversity these neurons are traditionally separated into broad commissural and corticofugal types, and until…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…