20 papers · ranked by Valyu relevance
Christopher C. Cline, Lily Forman, Winn Hartford, Jade Truong + 2 more
Image-guided positioning, or neuronavigation, is critical for precise targeting of transcranial magnetic stimulation (TMS) and other noninvasive brain stimulation. However, existing commercial systems have limitations in flexibility and extensibility for research applications. We present new open-source software for…
Wenzhi Bai, Andrew Weightman, Rory J O Connor, Zhengtao Ding + 3 more
— Transcranial magnetic stimulation (TMS) is a non-invasive and safe brain stimulation procedure with growing applications in clinical treatments and neuroscience research. However, achieving precise stimulation over prolonged sessions poses significant challenges. By integrating advanced robotics with conventional…
Marcin Karol Setlak, Bartłomiej Błaszczyk, Krzysztof Suszyński, Sylwia Szostek-Rogula + 3 more
Highlights What are the main findings?1. Neuronavigated rTMS may improve the precision, reproducibility, and documentation of stimulation targets in neurorehabilitation. 2. Current clinical evidence remains strongest for conventional rTMS protocols, particularly in post-stroke motor recovery, whereas data on…
Frank Preiswerk, Spencer T. Brinker, Nathan McDannold, Timothy Y. Mariano
'Timothy Y. Mariano'] Abstract. In recent years, non-invasive neuro-modulation methods such as Focused Ultrasound (FUS) have gained popularity. The aim of this work is to introduce the use of existing open-source technology for surgical navigation to the field of multimodal non-invasive brain stimulation. Unlike…
Sarah Gutmann, Miriam Heiderhoff, Robert Möbius, Tanja Siegel + 1 more
'Thomas Flegel'] Background Optical neuronavigation systems using infrared light to create a virtual reality image of the brain allow the surgeon to track instruments in real time. Due to the high vulnerability of the brain, neurosurgical interventions must be performed with a high precision. The aim of the…
Robrecht Dockx, Kathelijne Peremans, Romain Duprat, Lise Vlerick + 6 more
'Nick Van Laeken' 'Jimmy H. Saunders' 'Ingeborgh Polis' 'Filip De Vos' 'Chris Baeken' 'Darren Burke'] Background In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in dogs…
Dogu Baran Aydogan, Victor H. Souza, Renan H. Matsuda, Pantelis Lioumis + 1 more
State-of-the-art navigated transcranial magnetic stimulation (nTMS) systems can display the TMS coil position relative to the structural magnetic resonance image (MRI) of the subject’s brain and calculate the induced electric field. However, the local effect of TMS propagates via the white-matter network to different…
Albert Joseph Sulangi, Adam Husain, Haoyi Lei, Jessica Okun
Background Glioma resection aims for maximal tumor removal while preserving neurological function. Neuronavigation systems (NS), with intraoperative imaging, have revolutionized this process through precise tumor localization and detailed anatomical navigation. Objective To assess the efficacy and breadth of…
Xuyi Hu, Ke Ma, Siwei Liu, Per Ola Kristensson + 1 more
Once a fiducial marker is detected, the algorithm provides the 2D image coordinates of the tag corners. Then, the camera projection matrix as defined in Equation 1 establishes 3D-to-2D correspondences. Given a set of known 3D landmarks (e.g., AprilTag marker corners) and their corresponding 2D image projections, we…
Borna Mahmoudian, Hitarth Dalal, Jonathan Lau, Benjamin Corrigan + 5 more
Precise targeting of deep brain structures in humans and large animal models has been a challenge for neuroscientists. Conventional protocols used in animal models typically require large access chambers which are prone to infection and involve assembly and implantation of complex microdrives for semi-chronic…
Moritz Dannhauer, Ziping Huang, Lysianne Beynel, Eleanor Wood + 2 more
Transcranial magnetic stimulation (TMS) can modulate brain function via an electric field (E-field) induced in a region of interest (ROI) in the brain. The ROI E-field can be computationally maximized and set to match a specific reference using individualized head models to find the optimal coil placement and stimulus…
Maryam Rahimi-Balaei, Hugo Bergen, Jiming Kong, Hassan Marzban
Neuronal migration is a fundamental process in central nervous system (CNS) development. The assembly of functioning neuronal circuits relies on neuronal migration occurring in the appropriate spatio-temporal pattern. A defect in the neuronal migration may result in a neurological disorder. The cerebellum, as a part of…
Rui Ponte Costa
Axon guidance (AG) towards their target during embryogenesis or after injury is an important issue in the development of neuronal networks. During their growth, axons often face complex decisions that are difficult to understand when observing just a small part of the problem. In this work we propose a computational…
Jayesh Choudhary, Vivek A. Saraswat, Udayan Ganguly
In this work, we aim to devise an end-to-end spiking implementation for contour tracking in 3D media inspired by chemotaxis, where the worm reaches the region which has the given set concentration. For a planer medium, efficient contour tracking algorithms have already been devised, but a new degree of freedom has…
Xia Tang, William G. Wadsworth, Juan-Pablo Labrador
Axons in Caenorhabditis elegans are guided by multiple extracellular cues, including UNC-6 (netrin), EGL-20 (wnt), UNC-52 (perlecan), and SLT-1 (slit). How multiple extracellular cues determine the direction of axon guidance is not well understood. We have proposed that an axon's response to guidance cues can be…
Ana M. Mihut, Graham Morgan, Marcus Kaiser
Motivation: Neural development represents not only an exciting and complex field of study, with ongoing progress, but it also became the epicentre of neuroscience and developmental biology, as it strives to describe the underlying cellular and molecular mechanisms by which the central nervous system emerges during the…
Hua-Li Yu, Yun Peng, Yang Zhao, Yong-Sheng Lan + 9 more
Myosin X (Myo X) transports cargos to the tip of filopodia for cell adhesion, migration, and neuronal axon guidance. Deleted in Colorectal Cancer (DCC) is one of Myo X cargos essential for Netrin-1-regulated axon pathfinding. Myo X’s function in axon development in vivo and the underlying mechanisms remain poorly…
Ben Varkey Benjamin, Nicholas A Steinmetz, Nick N Oza, Jose J Aguayo + 1 more
A central challenge for systems neuroscience and artificial intelligence is to understand how cognitive behaviors arise from large, highly interconnected networks of neurons. Digital simulation is linking cognitive behavior to neural activity to bridge this gap in our understanding at great expense in time and…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…