23 papers · ranked by Valyu relevance
Theodore Dimitrov, Vikas Munjal, Allison O’Brien, Matthew T. Rocco + 4 more
This study explores the potential of adeno-associated virus serotype 9 (AAV9) to deliver therapeutic genes directly into the memory circuit throughout the olfactory bulb (OB), a critical memory and sensory processing region. Using convection-enhanced delivery (CED) of AAV9 encoding green fluorescent protein (GFP), we…
Naina Bhatia-Dey, Thomas Heinbockel, Paul B. Tchounwou, Daniel F. Sarpong + 6 more
'Daniel F. Sarpong' 'Elizabeth O. Ofili' 'Emma Fernandez-Repollet' 'Richard J. Noel' 'Magda Shaheen' 'Kristen J. Wells' 'Richard Yanagihara'] Research studies that focus on understanding the onset of neurodegenerative pathology and therapeutic interventions to inhibit its causative factors, have shown a crucial role of…
Thomas Brandt, Doreen Huppert
Phylogenetically, the chemical sense of smell is the oldest of all sensory modalities in terrestrial and aquatic organisms. For most non-human species in the wild, it is essential like other senses for survival because it aids nutrition, detection of environmental threats, and mating. In contrast to other senses…
Kensaku Mori, Hiroyuki Manabe, Kimiya Narikiyo, Naomi Onisawa
The orbitofrontal cortex receives multi-modality sensory inputs, including olfactory input, and is thought to be involved in conscious perception of the olfactory image of objects. Generation of olfactory consciousness may require neuronal circuit mechanisms for the “binding” of distributed neuronal activities, with…
Irene Fatuzzo, Giovanni Francesco Niccolini, Federica Zoccali, Luca Cavalcanti + 8 more
'Luca Cavalcanti' 'Mario Giuseppe Bellizzi' 'Gabriele Riccardi' 'Marco de Vincentiis' 'Marco Fiore' 'Carla Petrella' 'Antonio Minni' 'Christian Barbato' 'Yasemin M. Akay'] Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction is one of the early signs of prodromal…
Sebastian H. Bitzenhofer, Elena A. Westeinde, Han-Xiong Bear Zhang, Jeffry S. Isaacson
Olfactory information is encoded in lateral entorhinal cortex (LEC) by two classes of layer 2 (L2) principal neurons: fan and pyramidal cells. However, the functional properties of L2 neurons are unclear. Here, we show in awake mice that L2 cells respond rapidly to odors during single sniffs and that LEC is essential…
Simon Daste, Tuan H. Pham, Max Seppo, Alexandre André + 8 more
Sensory processing in the mammalian cortex relies on extensive feedforward and feedback connections, yet how information is routed along these pathways remains poorly understood. Here, we examined the functional properties of feedback and feedforward neurons in the mouse olfactory (piriform) cortex. We selectively…
Nabil Imam, Matthew Kielo, Brandon M. Trude, Barbara L. Finlay
Analysis of brain volumes across mammalian taxonomic groups reveal a pattern of complementary and inverse covariation between major brain components, including a robust negative covariation between the limbic system and neocortex. To understand the computational basis of this covariation, we investigated the…
Dilara Aktas, Beyza E. Ortlek, Meltem Civas, Elham Baradari + 4 more
'Ayse Sila Okcu' 'Melanie Whitfield' 'Oktay Cetinkaya' 'Özgür B. Akan'] Abstract—Humankind mimics the processes and strategies that nature has perfected and uses them as a model to address its problems. That has recently found a new direction, i.e., a novel communication technology called molecular communication (MC)…
Bhushan Deshpande
Named Entity Recognition (NER) in low-resource languages suffers from limited supervision and a lack of high-quality pretrained embeddings. Biological olfaction, which relies on sparse combinatorial coding through receptor and glomerular organization, offers a compelling paradigm for learning robust representations…
Kate A. White, Yun-Feng Zhang, Zhijian Zhang, Janardhan P. Bhattarai + 8 more
Sensory cortices process stimuli in manners essential for perception. The piriform ‘primary’ olfactory cortex (PCX) extends dense association fibers into the ventral striatum’s olfactory tubercle (OT), yet the function of this cortico-striatal pathway is unknown. We optically stimulated channelrhodopsin-transduced PCX…
Jiawei Zhang
In this paper, we will provide an introduction to the brain structure and function. Brain is an astonishing living organ inside our heads, weighing about 1.5kg, consisting of billions of tiny cells. The brain enables us to sense the world around us (to touch, to smell, to see and to hear, etc.), to think and to respond…
Ganesh Elumalai, Harshita Chatterjee, Imran Shareef Syed, Valencia Brown + 10 more
Different aspects of spatial neglect, the disability to locate the position of the source of an external stimulus, has been studied frequently especially with regards to lack of response to visual stimuli. A modicum of papers fails to elaborate on that of the auditory field and even less conducted on the extraction of…
JF. Raspeño-García, S. González-Granero, V. Herranz-Pérez, A. Cózar-Cuesta + 4 more
The mammalian olfactory system is responsible for processing volatile chemical stimuli and is composed of several structures including the olfactory epithelium, olfactory bulb, olfactory peduncle (OP), and olfactory cortices. Despite the critical role played by the OP in the transport of information it has remained…
Xiuxin Xia, Yuchen Guo, Yanwei Wang, Yuchao Yang + 2 more
'Hong Men'] Abstract—Odor sensory evaluation has a broad application in food, clothing, cosmetics, and other fields. Traditional artificial sensory evaluation has poor repeatability, and the machine olfaction represented by the electronic nose (E-nose) is difficult to reflect human feelings. Olfactory…
Éric Guedj, Matthieu Million, P. Dudouet, Hervé Tissot‐Dupont + 3 more
Purpose: Several brain complications of SARS-CoV-2 infection have been reported. It has been moreover speculated that this neurotropism could potentially cause a delayed outbreak of neuropsychiatric and neurodegenerative diseases of neuroinflammatory origin. A propagation mechanism has been proposed across the…
Gulce Nazli Dikecligil, Andrew I Yang, Nisha Sanghani, Timothy Lucas + 3 more
The human olfactory system has two discrete channels of sensory input, arising from olfactory epithelia housed in the left and right nostrils. Here, we asked whether primary olfactory cortex (piriform cortex, PC) encodes odor information arising from the two nostrils as unified or distinct stimuli. We recorded…
Alexandra M. A. C. Pinto
The olfactory system is constantly solving pattern-recognition problems by the creation of a large space to codify odour representations and optimizing their distribution within it. A model of the Olfactory Bulb was developed by Z. Li and J. J. Hopfield Li and Hopfield (1989) based on anatomy and electrophysiology.…
Rui Alvites, Abby Caine, Giunio Bruto Cherubini, Justina Prada + 3 more
'Artur Severo P. Varejão' 'Ana Colette Maurício' 'Thomas Heinbockel'] The Olfactory Bulb is a component of the Olfactory System, in which it plays an essential role as an interface between the peripheral components and the cerebral cortex responsible for olfactory interpretation and discrimination. It is in this…
Anca Rǎdulescu, Rachel Marra
The neuronal circuit that controls obsessive and compulsive behaviors involves a complex network of brain regions (some with known involvement in reward processing). Among these are cortical regions, the striatum and the thalamus (which compose the CSTC pathway), limbic areas such as the amygdala and the hippocampus…
Authors not listed
Despite its ubiquity in nature, some details of the animal olfactory system remain unclear. One such mystery is the mechanism by which olfactory receptors (ORs) recognize the olfactant molecules they bind to. Some evidence indicates that ORs can distinguish between molecules that differ only in isotopic composition…
Authors not listed
The mechanisms underlying human odor recognition remain largely unclear, making it challenging to predict the scent of a novel molecule based solely on its molecular structure. Unlike taste, which is classified into a limited number of categories, odor perception is highly complex and lacks universally defined labels…
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Machine olfaction—the artificial replication of the sense of smell—faces significant challenges due to the absence of large, standardized training datasets. Unlike vision, language, and audio models, which benefit from extensive corpora such as ImageNet, GLUE, and AudioSet, olfaction lacks scaled equivalents and…