25 papers · ranked by Valyu relevance
Letizia Lanzetti
By the time a tumor reaches clinical detectability, it contains around 108-109 cells. However, during tumor formation, significant cell loss occurs due to cell death. In some estimates, it could take up to a thousand cell generations, over a ~ 20-year life-span of a tumor, to reach clinical detectability, which would…
Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Seyed Mohammad Tavangar
'Seyed Mohammad Tavangar'] The new aspect of oncometabolite can be an indicator of genetic and epigenetic change and cancer biomarker.
Shukla Sarkar, Chien-I Chang, Jussekia Jean, Meng-Ju Wu
Oncometabolites are aberrant metabolic byproducts that arise from mutations in enzymes of the tricarboxylic acid (TCA) cycle or related metabolic pathways and play central roles in tumor progression and immune evasion. Among these, 2-hydroxyglutarate (2-HG), succinate, and fumarate are the most well-characterized…
David S. Wishart, Rupasri Mandal, Avalyn Stanislaus, Miguel Ramirez-Gaona + 2 more
'Miguel Ramirez-Gaona' 'Claudiu T. Supuran' 'Natalie Serkova'] The application of metabolomics towards cancer research has led to a renewed appreciation of metabolism in cancer development and progression. It has also led to the discovery of metabolite cancer biomarkers and the identification of a number of novel…
GaRyoung Lee, Sang Mi Lee, Sungyoung Lee, Chang Wook Jeong + 5 more
Oncometabolites, often generated as a result of a gene mutation, show pro-oncogenic function when abnormally accumulated in cancer cells. Identification of such mutation-associated metabolites will facilitate developing treatment strategies for cancers, but is challenging due to a large number of metabolites in a cell…
Samaneh Mostafavi, Hamidreza Zalpoor, Zuhair Mohammad Hassan
Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that suppress their anti-tumor activity. Toxic metabolites, such as lactate and ketone bodies, are produced mainly by catabolic cancer-associated fibroblasts (CAFs) to feed anabolic cancer cells. These…
Revathy Nadhan, Srishti Kashyap, Ji Hee Ha, Muralidharan Jayaraman + 4 more
'Yong Sang Song' 'Ciro Isidoro' 'Danny N. Dhanasekaran' 'Petr G. Lokhov'] Peritoneal cancers present significant clinical challenges with poor prognosis. Understanding the role of cancer cell metabolism and cancer-promoting metabolites in peritoneal cancers can provide new insights into the mechanisms that drive tumor…
Emanuela Di Gregorio, Gianmaria Miolo, Asia Saorin, Agostino Steffan + 3 more
'Giuseppe Corona' 'Karel Smetana Jr.' 'Michal Masarik'] Over the last decades, the study of cancer metabolism has returned to the forefront of cancer research and challenged the role of genetics in the understanding of cancer development. One of the major impulses of this new trend came from the discovery of…
Nader H. Mahmoudzadeh, Alexander J. Fitt, Daniel B. Schwab, William E. Martenis + 10 more
The oncometabolite L-2-hydroxyglutarate (L-2HG) is considered an abnormal product of central carbon metabolism that is capable of disrupting chromatin architecture, mitochondrial metabolism, and cellular differentiation. Under most circumstances, mammalian tissues readily dispose of this compound, as aberrant L-2HG…
Meena Kusi, Maryam Zand, Chun-Lin Lin, Chiou-Miin Wang + 5 more
Metabolic reprogramming in cancer cells not only sustains bioenergetic and biosynthetic needs but also influences transcriptional programs, yet how chromatin regulatory networks are rewired by altered metabolism remains elusive. Here we investigate genome-scale chromatin remodeling in response to 2-hydroxyglutarate…
Anja Karlstaedt, Heidi Vitrac, Rebecca L. Salazar, Benjamin D. Gould + 16 more
About 20-30% of cancer-associated deaths are due to complications from cachexia which is characterized by skeletal muscle atrophy. Metabolic reprogramming in cancer cells causes body-wide metabolic and proteomic remodeling, which remain poorly understood. Here, we present evidence that the oncometabolite…
Jonathan K. Yan, Ying Yang, Wenqi Wang
Cancer metastasis is a leading cause of cancer-related deaths, while its underlying mechanisms remain incompletely understood. To colonize distant organs, cancer cells reprogram their metabolism to adapt to diverse environmental challenges. Therefore, elucidating the metabolic pathways that drive cancer metastasis will…
Pavana Thomas, Chandra Bhavani, Sweta Srivastava
In their quest for autonomy, tumor cells are known to reroute metabolic networks to aid their proliferation and survival. These metabolic alterations are governed by the tumor sub-population, thereby contributing towards an additional layer of complexity within the already heterogeneous tumor. For instance, bulk…
Vidhi Kulkarni, Igor Tsigelny, Valentina Kouznetsova
Feline mammary carcinoma (FMC) is a prevalent and fatal carcinoma that predominantly affects unsprayed female cats. FMC is the third most common carcinoma in cats but is still underrepresented in research. Current diagnosis methods include physical examinations, imaging tests, and fine-needle aspiration. The diagnosis…
Loan Vulliard, Teresa Glauner, Sven Truxa, Miray Cetin + 7 more
Colorectal cancer (CRC) is highly heterogeneous, with five-year survival rates dropping from ~90% in localized disease to ~15% with distant metastases. Disease progression is shaped not only by tumor-intrinsic alterations but also by the reorganization of the tumor microenvironment (TME). Metabolic, compositional, and…
Neeltje van den Berg, Matouš Elphick, Kevin Mulder, Omar Bouricha + 3 more
- 1The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK - 2Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK - 3Cancer Research UK Scotland Institute, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK - 4School…
Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung + 8 more
'Sukjin Yang' 'Shubham Tripathi' 'Madeline Galbraith' 'Youyuan Deng' 'Mohit Kumar Jolly' 'Benny Abraham Kaipparettu' 'José N. Onuchic' 'Herbert Levine'] 1 Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA; 2 Department of Molecular and Human Genetics, Baylor College of Medicine…
Jayden Mckinnon, Heloisa Milioli, Carley Purcell, Christine Chaffer + 4 more
Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) of metabolites can reveal how metabolism is altered throughout heterogeneous tissues. Here MALDI-MSI has been coupled with laser post-ionsiation (MALDI-2) and applied to the MSI of metabolites for the first time. Using mouse kidney and…
Roba Abukwaik, Elías Vera-Sigüenza, Daniel A. Tennant, Fabian Spill
Warburg Effect Authors: ['Roba Abukwaik' 'Elías Vera-Sigüenza' 'Daniel A. Tennant' 'Fabian Spill'] Cancer cells exhibit significant alterations in their metabolism, characterised by a reduction in oxidative phosphorylation (OXPHOS) and an increased reliance on glycolysis, even in the presence of oxygen. This metabolic…
Authors not listed
Imaging small polar metabolites and analyzing their in vivo dynamics with stable isotope labeled (SIL) tracing through various biochemical pathways, including citric acid (TCA) cycle, glycolysis, and amino acid metabolism, has gained substantial interest over the years. However, imaging these small polar metabolites…
Authors not listed
A quantitative high throughput screen (qHTS) of 7,988 compounds with annotated libraries using biliary tract cancer cell lines with or without isocitrate dehydrogenase I (IDH1) mutations had identified YC-1 as being selectively cytotoxic against the IDH1 mutant cell lines. We present the structure-activity relationship…
Authors not listed
Carnitine and its acyl derivatives are essential for the transport of fatty acids from the cytosol into the mitochondrial matrix for β-oxidation, which supplies the cell with energy. Altered transport and metabolism of carnitine are associated with multiple diseases and disorders, including heart disease, insulin…
Ali Cakmak, M. Hasan Celik
— The metabolic wiring of patient cells is altered drastically in many diseases, including cancer. Understanding the nature of such changes may pave the way for new therapeutic opportunities, as well as the development of personalized treatment strategies for patients. In this paper, we propose an algorithm…
Ying Li
I would like to take this opportunity to express my sincere gratitude to my supervisor. I can honestly say that without you, this thesis would not exist. Thank you for being a role model and inspiring me into pursuing an education in the field of Occupational Health. Dr. Héroux runs the lab with his own money, and…
Authors not listed
Cell therapies (CT) have demonstrated life-changing benefits and curative options to patients with unmet medical needs. Recent commercial successes have strengthened support for the industry; strong clinical responses are propelling additional CT products toward commercialisation. However, manufacturing of CT products…