22 papers · ranked by Valyu relevance
Piero Picci
Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells. The classic osteosarcoma is a rare (0.2% of all malignant tumours) highly malignant tumour, with an estimated incidence of 3 cases/million population/year.…
Ander Abarrategi, Juan Tornin, Lucia Martinez-Cruzado, Ashley Hamilton + 6 more
'Ashley Hamilton' 'Enrique Martinez-Campos' 'Juan P. Rodrigo' 'M. Victoria González' 'Nicola Baldini' 'Javier Garcia-Castro' 'Rene Rodriguez'] Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone. Although standard chemotherapy has significantly improved long-term survival over the…
Maurizio Cè, Michaela Cellina, Thirapapha Ueanukul, Gianpaolo Carrafiello + 6 more
'Gianpaolo Carrafiello' 'Rawee Manatrakul' 'Phatthawit Tangkittithaworn' 'Suphaneewan Jaovisidha' 'Praman Fuangfa' 'Donald Resnick' 'Franck Verrecchia'] Title: Simple Summary Osteosarcoma is a primary malignant bone tumor that produces an osteoid matrix. Imaging is crucial for detection, characterization, and treatment…
Neha Bhardwaj, Vikas Bachhal, Uma Nahar Saikia
Osteosarcoma is an intramedullary high-grade osteoid-producing sarcoma. It has a preference for sites of the most proliferative growth plates.1 They occur in the metaphysis of long bones, commonly with direct extension into the adjacent epiphysis and diaphysis. It has a bimodal presentation, with most cases between the…
K.A. Rejniak, M.C. Lloyd, D.R. Reed, M.M. Bui
Osteosarcoma is the most common primary bone tumor in pediatric and young adult patients. Successful treatment of osteosarcomas requires a combination of surgical resection and systemic chemotherapy, both neoadjuvant (prior to surgery) and adjuvant (after surgery). The degree of necrosis following neoadjuvant…
Yongfeng Dou, Kai Zhu, Zhaozhong Sun, Xiaopeng Geng + 1 more
Osteosarcoma is a common malignant bone tumor in children and adolescents under the age of 20. However, research on the pathogenesis and treatment of osteosarcoma is still insufficient. In the present study, based on gene-phenotype correlation network, an analysis was performed to screen disorders related to…
Xuejing zheng, Jin Yuan, Peng Jin, Xuejun Wang + 5 more
Osteosarcoma, a highly heterogeneous malignant bone tumor, exhibits profound interpatient and intratumoral heterogeneity. Through integrated single-cell RNA sequencing and spatial transcriptomics, we identified distinct transcriptional profiles in the tumor microenvironment (TME) across patients, underscoring…
D. M. Anisuzzaman, Hosein Barzekar, Ling Tong, Jake Luo + 1 more
In the U.S, 5-10% of new pediatric cases of cancer are primary bone tumors. The most common type of primary malignant bone tumor is osteosarcoma. The intention of the present work is to improve the detection and diagnosis of osteosarcoma using computer-aided detection (CAD) and diagnosis (CADx). Such tools as…
Jiaxun Song, Xiaofeng Yuan, Lianhua Piao, Jiawen Wang + 4 more
'Ming Zhuang' 'Jie Liu' 'Zhiwei Liu'] Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient sensitivity for the means of…
Raisa Fairooz Meem, Khandaker Tabin Hasan
The field of clinical image analysis has been applying transfer learning models increasingly due to their less computational complexity, better accuracy etc. These are pre-trained models that don't require to be trained from scratch which eliminates the necessity of large datasets. Transfer learning models are mostly…
Adepitan A. Owosho, Adeola M. Ladeji, Olufunlola M. Adesina, Kehinde E. Adebiyi + 8 more
Primary osteosarcomas of the jaw (OSJ) are rare, accounting for 6% of all osteosarcomas. This study aims to determine the value of SATB2 and MDM2 immunohistochemistry (IHC) in differentiating OSJ from other jawbone mimickers, such as benign fibro-osseous lesions (BFOLs) of the jaw or Ewing sarcoma of the jaw. Certain…
Liangrui Pan, Hetian Wang, Wang Lian, Boya Ji + 4 more
'Mitchai Chongcheawchamnan' 'Jin Yuan' 'Shaoliang Peng'] Abstract—The degree of malignancy of osteosarcoma and its tendency to metastasize/spread mainly depend on the pathological grade (determined by observing the morphology of the tumor under a microscope). The purpose of this study is to use artificial intelligence…
Lauren J. Mills, Milcah C. Scott, Pankti Shah, Anne R. Cunanan + 9 more
Osteosarcoma is an aggressive tumor of the bone that primarily affects young adults and adolescents. Osteosarcoma is characterized by genomic chaos and heterogeneity. While inactivation of tumor suppressor p53 TP53 is nearly universal other high frequency mutations or structural variations have not been identified.…
Habitha Sri Prabhakaran, Neil Alan Cross
Osteosarcoma is a bone malignancy most prevalent in adolescent populations. Despite advances in multi-agent chemotherapies and surgical procedures, the survival rate remains <30% for patients with metastasis. Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising anti-cancer agent, but when…
Qingzhu Liu, Cong Zhou, Ke Xu, Qikui Zhu + 11 more
Defining the transition from localized to metastatic osteosarcoma (OS) before overt dissemination is fundamental for improving survival. However, effective early diagnostic tools remain scarce, largely due to limited exploitation of the pre-metastatic tumor microenvironment’s own record of molecular barcode exposures…
Francesco R. Evola, Luciano Costarella, Vito Pavone, Giuseppe Caff + 4 more
'Luca Cannavò' 'Andrea Sessa' 'Sergio Avondo' 'Giuseppe Sessa'] Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in…
Carolina Vargas-Ecos, Edwin Salcedo
—According to the Pan American Health Organization, the number of cancer cases in Latin America was estimated at 4.2 million in 2022 and is projected to rise to 6.7 million by 2045. Osteosarcoma, one of the most common and deadly bone cancers affecting young people, is difficult to detect due to its unique texture and…
David Joon Ho, Narasimhan P. Agaram, M.-H. Jean, Stephanie D. Suser + 7 more
'Cynthia Chu' 'Chad Vanderbilt' 'Paul A. Meyers' 'Leonard H. Wexler' 'John H. Healey' 'Thomas J. Fuchs' 'Meera Hameed'] TJF is co-founder, chief scientist and equity holder of Paige.AI. CMV is a consultant (uncompensated) and equity holder in Paige.AI. DJH, NPA, CMV, TJF, and MRH have intellectual property interests…
Melissa Mathias, Alexander J Chou, Paul Meyers, Neerav Shukla + 6 more
Poorly differentiated round cell sarcomas present diagnostic challenges due to their variable morphology and lack of specific immunophenotypic markers. We present a case of a 15-year-old female with a tibial tumor that exhibited features of Ewing-like sarcoma, including apparent rearrangement of the EWSR1 gene.…
David Joon Ho, Narasimhan P. Agaram, Peter J. Schüffler, Chad Vanderbilt + 3 more
'Chad Vanderbilt' 'Marc-Henri Jean' 'Meera Hameed' 'Thomas J. Fuchs'] Abstract. Osteosarcoma is the most common malignant primary bone tumor. Standard treatment includes pre-operative chemotherapy followed by surgical resection. The response to treatment as measured by ratio of necrotic tumor area to overall tumor area…
Carley V. Cook, Ariel M. Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important…
Vidhyavathy Nagarajan, Shreya S. Karandikar, Mary S.J. Dhevanayagam
Sarcoma is a rare malignancy with poor prognosis, especially in older patients (≥ 65 years) as seen in our preliminary analysis and some previous studies. Moreover, these patients have limited treatment options due to therapy-associated adverse effects and altered tumor micro-environment, which could be associated with…