26 papers · ranked by Valyu relevance
Sandeep Verma, Rajesh Kumar, Gajendra Kumar Katara, Laishram Chandreshwor Singh + 4 more
'Laishram Chandreshwor Singh' 'Narender Singh Negi' 'V. Ramesh' 'Poonam Salotra' 'Mauricio Martins Rodrigues'] A rapid and accurate method to detect and quantify Leishmania parasite is urgently needed to facilitate early diagnosis of Leishmaniasis and monitoring of antileishmania therapy. In this study, real-time assay…
Gustavo Fabián Enriquez, Jacqueline Bua, María Marcela Orozco, Natalia Paula Macchiaverna + 5 more
'Natalia Paula Macchiaverna' 'Julián Antonio Alvarado Otegui' 'Hernán Darío Argibay' 'María del Pilar Fernández' 'Ricardo Esteban Gürtler' 'Marta Victoria Cardinal'] Background The distribution of parasite load across hosts may modify the transmission dynamics of infectious diseases. Chagas disease is caused by a…
Tatyana Kobets, Marie Čepičková, Valeriya Volkova, Yahya Sohrabi + 4 more
'Helena Havelková' 'Milena Svobodová' 'Peter Demant' 'Marie Lipoldová'] Leishmaniasis is a serious health problem in many countries, and continues expanding to new geographic areas including Europe and USA. This disease, caused by parasites of Leishmania spp. and transmitted by phlebotomine sand flies, causes up to 1.3…
Bradley A. Mullens, Katherine A. Luhring
Heleidomermis magnapapula parasitizes the blood-feeding midge Culicoides sonorensis. Most (84%) single mermithid infective second stage juveniles (J2) developed into adult females, while parasitism by multiple J2 yielded 97% male adults. Nematodes emerged from the midge larval host as adults and mated immediately…
Tom Sistermans, Juliane Hartke, Marah Stoldt, Romain Libbrecht + 1 more
Parasites with complex life cycles are known to induce phenotypic changes in their intermediate hosts to increase transmission to the final host. The magnitude of these changes could increase with the number of parasites, which would be beneficial to co-infecting parasites. Yet, adverse effects of high parasite load…
Aubrey J. Cunnington, Glenn F. Rall
It seems obvious that the number of pathogens should be important in the pathogenesis of an infectious disease [1], [2]. The relationship between the pathogen load and severity is one of the most fundamental questions, and yet, strangely, one of the most difficult to answer [3]. One reason for this is that it is often…
Hermien Viljoen, Nigel C. Bennett, Edward A. Ueckermann, Heike Lutermann + 1 more
'Heike Lutermann' 'Matty Knight'] The distribution of parasites among hosts is often characterised by a high degree of heterogeneity with a small number of hosts harbouring the majority of parasites. Such patterns of aggregation have been linked to variation in host exposure and susceptibility as well as parasite…
Romain Pigeault, Camille-Sophie Cozzarolo, Jérôme Wassef, Jérémy Gremion + 3 more
Although avian haemosporidian parasites are widely used as model organisms to study fundamental questions in evolutionary and behavorial ecology of host-parasite interactions, some of their basic characteristics, such as seasonal variations in within-host density, are still mostly unknown. In addition, their interplay…
Gonzalo Maximiliano Lopez, Juan Pablo Aparicio
The basic models are derived from general probabilistic models for the parasite density-dependent mating probability. Here we considered the particular, and common case, of a negative binomial distribution for the number of parasites in hosts. We find the basic reproductive number and we show that the system exhibit a…
Aurélie Jeantet, Fabienne Audebert, Simon Agostini, Beatriz Decencière + 5 more
Within a host, parasites form a community and interact with each another. They can interact directly through competition for space or indirectly through competition for resources, or even via the host’s immune response. These interactions can influence infection patterns within the host. In particular, helminths are…
Alex A. Volinsky, Nikolai V. Gubarev, Galina M. Orlovskaya, Elena V. Marchenko
'Elena V. Marchenko'] Human intestinal helminths are described in this paper. They can be over a meter long, with an irregular cylindrical shape, resembling a rope. These anaerobic intestinal "rope" parasites differ significantly from other well-known intestinal parasites. Rope parasites can leave human body with…
Rafiatu Imoro, Maica Krizna Gavina, Vachel Gay Paller, Jomar Rabajante + 2 more
'Jomar Rabajante' 'Mark Jayson Cortez' 'Editha Jose'] - Developed a mathematical model to show the dynamics of STH transmission with human-animal-environment interactions - Ingestion rate, disease progression rate, and shedding rate, increase infection while higher clearance and recovery rates decrease infection - The…
Philipp Kirstahler, Frank M. Aarestrup, Sünje Johanna Pamp
Despite a yearly death toll of up to one million people due to parasite-related infections, parasites are still neglected in genomics research. While there is progress in the detection of bacteria and viruses using metagenomics in the context of infectious diseases, there are still challenges in metagenomics-based…
R. McVinish
acquisition Authors: ['R. McVinish'] Abstract. The Tallis-Leyton model is a simple model of parasite acquisition where there is no interaction between the host and the acquired parasites. We examine the effect of model parameters on the distribution of the host's parasite burden in the sense of the Lorenz order. This…
Juan Diego González-Luna, Francisco Gaytán
Human parasitic infections are major contributors to global disease load, compromising the human life and resulting in considerable morbidity and mortality worldwide. However, many parasitic diseases have been neglected and little investigated in western medicine. Although recently developed molecular techniques have…
Colin J. Carlson, Oliver C. Muellerklein, Anna J. Phillips, Kevin R. Burgio + 11 more
Parasite conservation is a rapidly growing field at the intersection of ecology, epidemiology, parasitology, and public health. The overwhelming diversity of parasitic life on earth, and recent work showing that parasites and other symbionts face severe extinction risk, necessitates infrastructure for parasite…
Usman Sanusi, Sona John, Johannes Mueller, Aurélien Tellier
Mathematical modelling of epidemiological and coevolutionary dynamics is widely being used to improve disease management strategies of infectious diseases. Many diseases present some form of intra-host quiescent stage, also known as covert infection, while others exhibit dormant stages in the environment. As…
Marie J. E. Charpentier, Peter M. Kappeler
In a recent article, Bicca-Marques and Calegaro-Marques [2016] discussed the putative assumptions related to an interpretation we provided regarding an observed positive relationship between weekly averaged parasite richness of a group of mandrills (Mandrillus sphinx) and their daily path lengths (DPL), published…
Oksana Desiatkina, Martin Mösching, Nicoleta Anghel, Ghalia Boubaker + 4 more
Aiming to generate novel compounds with improved antitoxoplama activity by exploiting the parasite auxotrophies, a library of nucleic base-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates - was synthesized and evaluated. Various structural features as the nucleobase (adenine, uracil, cytosine…
Authors not listed
Trypanosomiasis is one of the World’s Neglected Tropical Diseases (NTDs) that affects both man and animals. The current control measures are mostly chemotherapeutic which face numerous challenges such as non availability of drugs, toxicity and long term protocol. These challenges have made researchers look for…
Christopher Finn McQuaid, N. F. Britton
Patterns of nestedness and specialization asymmetry, where specialist species interact mainly with generalists while generalists interact with both generalists and specialists, are often observed in mutualistic and antagonistic bi-partite ecological networks. These have been explained in terms of the relative abundance…
Authors not listed
Neglected tropical diseases caused by trypanosomatid parasites such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi present a major public healthcare issue due in part to emerging resistance. Exploring multiple targeting ligands, conjugates composed of analogs from the ribosomal inhibitor anisomycin and…
Authors not listed
In this study, we investigated the antiplasmodial properties of a series of fluorinated peptoid-capped histone deacetylase inhibitors (HDACi) against asexual blood stages of the drug-sensitive 3D7 and drug-resistant Dd2 strains of Plasmodium falciparum, as well as the exo-erythrocytic liver stages and mature…
wenzhong liu, hualan li
Malaria symptoms are very similar to those of COVID-19, and infections can be symptomatic or asymptomatic. Common immunodominant epitopes are shared by the SARS-CoV-2 proteins and the Plasmodium falciparum antigen. Through bioinformatics methods such as domain search, this study discovered that the S, ORF3a proteins…
Sodeeq Babalola, Hayatudeen Muhammad, Abdullah Idris, Asmau Hamza
Malaria remain an epidermic infectious disease that is ravaging the world most especially sub-Sahara Africa. Due to the prevalence of Plasmodium parasites that are resistant to first-line antimalarial drugs, it is urgently necessary to create new scaffolds and find strategies to overcome drug resistance. Chalcones are…
Authors not listed
Background: Leishmania parasites cause neglected tropical diseases such as cutaneous and visceral leishmaniasis, which have limited treatment options and rising drug resistance. Protein kinases are pivotal in Leishmania biology and attractive drug targets, but their functional status in the parasite remains largely…