27 papers · ranked by Valyu relevance
Nicole M. Gilbert, Amanda L. Lewis, Kimberly A. Kline
Our understanding of microbial pathogenesis is founded largely on the assumption that the microbe responsible for causing a disease is the one that is abundantly present at the time and site of disease symptoms. This situation can be compared to the scenario in which a criminal is caught red-handed at the scene of the…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias…
Ambreen Talib, Rabbya Rayan Shah, Rameen Atique, Hafiza Arshi Saeed + 5 more
'Ayesha Haidar' 'Ayesha Nadeem' 'Areesha Naveed' 'Javeria Sharif' 'Abdul Samad'] Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public health. It is a member of the Togaviridae family and alphavirus genus and causes an arthritogenic disease known as Chikungunya fever (CHIKF). It is a…
Anjali Gupta, Robert L. Unckless
The pathogenicity of a microbe is difficult to define in a comparative context: across microbes with varying virulence or across host genotypes with varying susceptibilities. Several different statistical approaches have been employed to investigate pathogenicity and susceptibility. Measures like proportional mortality…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Liise-anne Pirofski, Arturo Casadevall
Proof of the Germ theory of disease and acceptance of Koch’s postulates in the late 1890’s launched the fields of microbial pathogenesis and infectious diseases and provided the conceptual framework that has guided thought and research in these fields. A central tenet that emerged from studies with microbes that…
Lawrence S. Young
Infection ranks alongside cardiovascular disease as the major cause of human death across the world. Word Health Organization data for 2002 shows that 26% of all deaths, almost 15 million in number, were due to infectious disease with HIV/AIDS, TB and malaria being the top three responsible infections. A significant…
Crispin Zavala-Alvarado, Odile Sismeiro, Rachel Legendre, Hugo Varet + 7 more
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. During infection, Leptospira are confronted with dramatic adverse environmental changes such as deadly reactive oxygen species (ROS). Withstanding ROS produced by the host innate immunity is an important strategy…
Anna Onisiforou, George M. Spyrou
During the course of a viral infection, virus-host protein-protein interactions (PPIs) play a critical role in allowing viruses to evade host immune responses, replicate and hence survive within the host. These interspecies molecular interactions can lead to viral-mediated perturbations of the human interactome causing…
Crispin Zavala-Alvarado, Samuel Garcia Huete, Antony T. Vincent, Odile Sismeiro + 9 more
Pathogenic Leptospira are the causative agents of leptospirosis, the most widespread zoonotic infectious disease. Leptospirosis is a potentially severe and life-threatening emerging disease with highest burden in sub-tropical areas and impoverished populations. Mechanisms allowing pathogenic Leptospira to survive…
Rafael Guillermo Villarreal-Julio, Valeria Isabel Manjarrez Montes, Brayan Estiven Ordoñez Perez, Jonny Andrés Yepes-Blandón
In Colombia, pathogenic knowledge of endemic Leptospira species is limited. Leptospira santarosai serogroup Autumnalis serovar Alice Strain JET was isolated from a patient from Urabá Antioquia, so it is necessary to know more about its genomic components and pathogenomics. A comparative analysis of the bacterial genome…
David Papo, Javier M. Buldú
If brain anatomy and dynamics have a genuine complex network structure as it has become standard to posit, it is also reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and…
Biplab Chattopadhyay, Nirmalendu Hui
- Disease psoriasis occurs as chronic inflammation of skin and appears as scaly red lesions on skin surface. Advent of several immunosuppressive drugs established that the disease stems from immunopathogenic disorder in human blood. Cell biological as well as clinical research on the disease reveals that the helper…
Mikhail Peslyak
Model of pathogenesis of psoriasis Part 2. Local processes Edition e1.3 Mikhail Peslyak UDC 616.5:616-092 Mikhail Yuryevich Peslyak Model of pathogenesis of psoriasis. Part 2. Local processes. Edition e1.3 (revised and updated), Russia, Moscow, MYPE, 2012.– 110 p. ISBN 978-5-905504-04-4 Copyright © 2011-2012, Mikhail…
Max L. Addison, Alexia Hapeshi, Elena Carter, Zi Xin Wong + 2 more
Photorhabdus asymbiotica is a species of the insect pathogenic Photorhabdus genus that has been isolated as an etiological agent in human infections. Since then, multiple isolates have been identified worldwide, however actual clinical infections have so far only been identified in North America, Australia and Nepal.…
Kyle Macauslane, Cassandra Pegg, Kirsty Short, Benjamin Schulz
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability, and the greatest burden of disease impacts children, pregnant women, and the elderly. Respiratory viruses account for the majority of ARIs. The unfolded protein response (UPR) is a host homeostatic defence mechanism primarily…
Chuang Li, Yichen Wei, Chao Qin, Shifan Chen + 1 more
line-encoded receptors Authors: ['Chuang Li' 'Yichen Wei' 'Chao Qin' 'Shifan Chen' 'Xiaolong Shao'] - 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China - 3 School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia - 4 Section of Infection and…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
C.J. Carter
Multiple pathogens have been detected in Alzheimer’s disease (AD) brains. A bioinformatics approach was used to assess relationships between pathogens and AD genes (GWAS), the AD hippocampal transcriptome and plaque or tangle proteins. Host/pathogen interactomes (C.albicans, C.Neoformans, Bornavirus, B.Burgdorferri…
Siobhán M. O'Connor, Christopher E. Taylor, James M. Hughes
Infectious agents, often through complex systems, likely determine more chronic diseases than is currently appreciated.
Daniel Adesse, Anne Caroline Marcos, Michele Siqueira, Cynthia M. Cascabulho + 3 more
Congenital toxoplasmosis is a parasitic disease that occurs due vertical transmission of the protozoan Toxoplasma gondii (T. gondii) during pregnancy. The parasite crosses the placental barrier and reaches the developing brain, infecting progenitor, glial, neuronal and vascular cell types. Although the role of Radial…
Alfonso Vivanco-Lira, R. Luna‐Banenelli
Measles is an infectious disease caused by the Morbilivirus Measles Virus which has accompanied the human race since the 4th millennium BC, it is a disease usually concerning the paediatric population and in the past, before the advent of vaccination, almost all the population suffered from it, and in some cases the…
Alexander Muacevic, John R Adler, George S Stoyanov, Galina Naskovska + 3 more
'Galina Naskovska' 'Emran Lyutfi' 'Rumiana Kirneva' 'Kameliya Bratoeva'] Pathophysiology is a medical science whose subject is the change in regulatory mechanisms related to the onset, development, and outcome of diseases. The first lectures on pathophysiology were held in 1790 at the University of Erfurt, Germany, by…
Steven A. Frank
The motor neuron disease amyotrophic lateral sclerosis (ALS) typically begins with localized muscle weakness. Progressive, widespread paralysis often follows over a few years. Does the disease begin with local changes in a small piece of neural tissue and then spread? Or does neural decay happen independently across…
Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich + 12 more
Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson’s disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known as “reduced penetrance”), with factors including age and geographic region…
Brian J. Balin, Christine J. Hammond, Christopher Scott Little, Susan T. Hingley + 4 more
'Susan T. Hingley' 'Zein Al-Atrache' 'Denah M. Appelt' 'Judith A. Whittum-Hudson' 'Alan P. Hudson'] The disease known as late-onset Alzheimer’s disease is a neurodegenerative condition recognized as the single most commonform of senile dementia. The condition is sporadic and has been attributed to neuronal damage and…
Jean-Laurent Casanova
In 1955, René Dubos famously expressed his “second thoughts on the germ theory”, attributing infectious diseases to various “changing circumstances” that weaken the host by unknown mechanisms. He rightly stressed that only a small minority of individuals infected by almost any microbe develop clinical disease.…