25 papers · ranked by Valyu relevance
Carmelo Biondo
Pathogenicity, or the ability of a microorganism to cause disease, depends on several factors, among which the immune status of the host and the microbial species involved in the exposure play a key role. Microbial pathogenicity is a complex, multifactorial process, governed by genetic and molecular features associated…
Anjali Gupta, Robert L. Unckless
The pathogenicity of a microbe is difficult to define in a comparative context: across microbes with varying virulence or across host genotypes with varying susceptibilities. Several different statistical approaches have been employed to investigate pathogenicity and susceptibility. Measures like proportional mortality…
Axel Cloeckaert, Daniel Pletzer, Svetlana Khaiboullina
Microbiology is a fast-growing research field. The rapid expansion of this field is driven by ongoing discoveries of emerging pathogens, microbial adaptation, resistance mechanisms and technological advancements. While these trends will likely continue to drive new discoveries and novel solutions for infectious…
Lingrong Yang, Wenwen Jin, Yanli Liu, Wei Hu + 4 more
Purulent meningitis is a common disease of the central nervous system affecting children. It arises from various pathogens transmitted through diverse routes and can lead to significant sequelae, even death. The pathogenesis involves varying degrees of meningeal damage by pathogens, breaching the blood-brain barrier…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias…
Martin Fischer, Tim Engelgeh, Patricia Rothe, Stephan Fuchs + 2 more
The Gram-positive bacterium Listeria monocytogenes occurs widespread in the environment and infects humans when ingested along with contaminated food. Such infections are particularly dangerous for risk group patients, for whom they represent a life-threatening disease. To invent novel strategies to control…
Ambreen Talib, Rabbya Rayan Shah, Rameen Atique, Hafiza Arshi Saeed + 5 more
'Ayesha Haidar' 'Ayesha Nadeem' 'Areesha Naveed' 'Javeria Sharif' 'Abdul Samad'] Chikungunya virus (CHIKV) is currently one of the most relevant arboviruses to public health. It is a member of the Togaviridae family and alphavirus genus and causes an arthritogenic disease known as Chikungunya fever (CHIKF). It is a…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Gemma G. R. Murray, A. S. Md. Mukarram Hossain, Eric Miller, Sebastian Bruchman + 26 more
The expansion and intensification of livestock production is predicted to promote the emergence of pathogens. As pathogens sometimes jump between species this can affect the health of humans as well as livestock. Here we investigate how livestock microbiota can act as a source of these emerging pathogens through…
Alexandre Giraud-Gatineau, Cecilia Nieves, Luke B. Harrison, Nadia Benaroudj + 2 more
Pathogenic Leptospira are spirochete bacteria which cause leptospirosis, a re-emerging zoonotic disease of global importance. Here, we use a recently described lineage of environmental-adapted leptospires, which are evolutionarily the closest relatives of the highly virulent Leptospira species, to explore the key…
Rafael Guillermo Villarreal-Julio, Valeria Isabel Manjarrez Montes, Brayan Estiven Ordoñez Perez, Jonny Andrés Yepes-Blandón
In Colombia, pathogenic knowledge of endemic Leptospira species is limited. Leptospira santarosai serogroup Autumnalis serovar Alice Strain JET was isolated from a patient from Urabá Antioquia, so it is necessary to know more about its genomic components and pathogenomics. A comparative analysis of the bacterial genome…
Elena Righetti, Alice Antonello, Luca Marchetti, Enrico Domenici + 1 more
'Federico Reali'] Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, yet there is no disease-modifying therapy up to this date. The biological complexity underlying PD hampers the investigation of the principal contributors to its pathogenesis. In this context, mechanistic models…
David Papo, Javier M. Buldú
If brain anatomy and dynamics have a genuine complex network structure as it has become standard to posit, it is also reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and…
William Monteith, Ben Pascoe, Evangelos Mourkas, Jack Clark + 6 more
Listeria monocytogenes is an opportunistic food-borne bacterium that is capable of infecting humans with high rates of hospitalisation and mortality. Natural populations are genotypically and phenotypically variable, with some lineages being responsible for most human infections. The success of L. monocytogenes is…
Max L. Addison, Alexia Hapeshi, Elena Carter, Zi Xin Wong + 2 more
Photorhabdus asymbiotica is a species of the insect pathogenic Photorhabdus genus that has been isolated as an etiological agent in human infections. Since then, multiple isolates have been identified worldwide, however actual clinical infections have so far only been identified in North America, Australia and Nepal.…
Kyle Macauslane, Cassandra Pegg, Kirsty Short, Benjamin Schulz
Acute respiratory infections (ARIs) are amongst the leading causes of death and disability, and the greatest burden of disease impacts children, pregnant women, and the elderly. Respiratory viruses account for the majority of ARIs. The unfolded protein response (UPR) is a host homeostatic defence mechanism primarily…
Shimi Chettiparambil Mohanan, Christina Surulescu, Neslihan Nesliye Pelen
Buruli ulcer (BU) is caused by Mycobacterium ulcerans, a member of the family of bacteria causing tuberculosis and leprosy. It is a neglected tropical or subtropical disease [16] characterised by destructive skin lesions and tissue damage. Delay of treatment results in prolonged periods in the hospital [4] and…
Chuang Li, Yichen Wei, Chao Qin, Shifan Chen + 1 more
line-encoded receptors Authors: ['Chuang Li' 'Yichen Wei' 'Chao Qin' 'Shifan Chen' 'Xiaolong Shao'] - 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China - 3 School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia - 4 Section of Infection and…
Menghan Zhang, Yuehua Liu
Obstructive sleep apnea (OSA) is a sleep respiratory disease characterized by sleep snoring accompanied by apnea and daytime sleeplessness. It is a complex disease, with the multifactorial etiology, and the pathology is incompletely understood. Genioglossus (GG), the largest dilator of upper airway, whose fatigue is…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Sanda Jurja, Alina Zorina Stroe, Mihaela Butcaru Pundiche, Silviu Docu Axelerad + 6 more
Cat-scratch disease is an illness caused by Bartonella henselae that occurs as a result of contact with an infected kitten or dog, such as a bite or scratch. It is more prevalent in children and young adults, as well as immunocompromised individuals. There are limited publications examining the features of CSD in…
Yingchao Li, Yuqing Wu, Suolin Li, Lin Liu + 3 more
'Jiaxun Lv' 'Qinqin Li'] Intestinal microecology is established from birth and is constantly changing until homeostasis is reached. Intestinal microecology is involved in the immune inflammatory response of the intestine and regulates the intestinal barrier function. The imbalance of intestinal microecology is closely…
Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich + 12 more
Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson’s disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known as “reduced penetrance”), with factors including age and geographic region…
Noely Evangelista Ferreira, Antonio C. da Costa, Esper G. Kallas, Cassia G. T. Silveira + 12 more
'Cassia G. T. Silveira' 'Ana Carolina S. de Oliveira' 'Layla Honorato' 'Heuder G. O. Paião' 'Silvia H. Lima' 'Dewton de M. Vasconcelos' 'Marina F. Côrtes' 'Silvia F. Costa' 'Tania R. T. Mendoza' 'Hélio R. Gomes' 'Steven S. Witkin' 'Maria C. Mendes-Correa' 'Sherif T. S. Hassan'] Parvovirus B19 infection is associated…
Jean-Laurent Casanova
In 1955, René Dubos famously expressed his “second thoughts on the germ theory”, attributing infectious diseases to various “changing circumstances” that weaken the host by unknown mechanisms. He rightly stressed that only a small minority of individuals infected by almost any microbe develop clinical disease.…