19 papers · ranked by Valyu relevance
Lucie A. L. Descamps, Wesley P. Clawson, Miguel M. Carvalho, Thomas Rogerson + 4 more
Remembering object locations is crucial for survival, yet how the anterior cingulate cortex (ACC) encodes spatial features across repeated experiences has not been fully characterized. Using longitudinal calcium imaging in freely moving mice, we tracked excitatory ACC neurons while animals explored objects across…
Kyle Bojanek, Olivier Marre, Stephanie E. Palmer
Populations of sensory neurons are thought to be shaped by selective pressures for optimal information transmission, yet real neural circuits display substantial variability across stimulus repeats, across time, and between individuals. Reconciling this variability with normative theories requires understanding not…
Liam Lang, Camelia Yuejiao Zheng, Jennifer M Blackwell, Giancarlo La Camera + 1 more
Cortical circuits produce time-varying patterns of population and single neuron activity that play a fundamental role in perceptual and behavioral processes. However, the functional contributions of individual neuron activity to population dynamics and behavior remain unclear. Here we addressed this issue focusing on…
Toktam Samiei, Hafiz Fareed Ahmed, Edward Zagha, Erfan Nozari
Despite over a century of research into the neural code, the fundamental principles by which the brain encodes sensory information remain debated. In this study we provide converging evidence for the presence of a dynamic, fast-switching integration of rate and temporal coding in the thalamus, primary visual cortex…
Liam Lang, Camelia Yuejiao Zheng, Jennifer M Blackwell, Giancarlo La Camera + 3 more
Cortical circuits produce time-varying patterns of population and single-neuron activity that play a fundamental role in perceptual and behavioral processes. However, the functional contributions of individual neuron activity to population dynamics and behavior remain unclear. Here, we addressed this issue focusing on…
Shuhong Huang, Ruben Portugues, James E. Fitzgerald
The ultimate goal of sensory coding is to extract and represent the cues required for adaptive motor output. This suggests that sensory codes and behavioral outcomes may align, and a variety of studies have argued that both biological and engineered sensory systems represent stimuli similarly when they play similar…
Taiane de Azevedo Cardoso, Alicia Stone, William Gray, Natalia Calanzani + 6 more
Background The North Central London (NCL) Cancer Alliance carried out a quality improvement (QI) project to fill a distinct knowledge gap regarding the quality of clinical coded data in a primary care electronic health care record system across the whole cancer pathway. Objective This study aims to establish the…
Keira Markey, Robyn Hamilton, Rohan Ahmed, Joyutpal Das + 7 more
Objectives To use automated coding to identify broad neurological diagnoses and link to sociodemographic data. Design Retrospective observational study. Setting Tertiary outpatient neurology services covering Greater Manchester and East Cheshire. Participants All adult patients attending neurology appointments between…
Barragan, Sandra, Pérez-Bote, Adrián + 6 more
We provide a description of pilot and production experiences to streamline some business functions in the official statistical production process using statistical learning models. Our approach is quality-oriented searching for an improvement on accuracy, cost-efficiency, timeliness, granularity, response burden…
Austin Daigle, Jacob Marsh, Andrew Kay, Parul Johri
Although non-coding regions play important roles in gene regulation and contribute to individual fitness, the precise distribution of fitness effects (DFE) of new mutations in these regions remains poorly understood. Here, we carefully compile experimentally validated regulatory regions in non-coding regions in the…
Jiang Shu, Danai Kasambira Fannin, Geraldine Dawson, Gary Maslow + 3 more
We next applied the learned classification model to the population-based classification task. Using just the clinical notes, we classified any encounter as speech-language delay whenever the model-predicted probability of speech-language delay was greater than 90%. This high threshold was selected to prioritize…
Marcos De Andrés Montero, Luca Kis, Olga Spekker, Viktor Vig + 8 more
The resolution of commingled human skeletal remains is a phenomenon increasingly encountered by archaeologists and anthropologists. Its difficulty is due to the complexity of the task itself, but also to the limited methodological resources available for researchers. Parallelly, its importance derives from the fact…
Robert W. Hurley, Daniel Guth, Elaine L. Hill, Meredith C. B. Adams + 1 more
The low sensitivity and high specificity pattern indicate that Z79.891 functions as a confirmatory code: its presence signals clinician recognition of LTOT, but its absence does not exclude LTOT. This is consistent with the dependence on clinician documentation behavior rather than objective measurement. Notably, PPV…
Authors not listed
High-level quantum mechanical (QM) simulations provide accurate electronic information of chemical systems but scale unfavourably with system size, making calculations of applied systems challenging. Hierarchical quantum mechanics in quantum mechanics embedding (QM/QM) addresses this issue by localising the highly…
Elijah Zolduoarrati, Sherlock A. Licorish, Nigel Stanger
Developers frequently reuse Stack Overflow code snippets, yet the quality of these snippets remains unevenly understood, particularly across programming languages and geographic contexts. This study investigates code quality in Stack Overflow answers from contributors located in the United States, focusing on SQL…
Authors not listed
Accurate modeling of drug concentration--time (C--t) profiles is central to pharmacokinetics (PK) and plays a critical role in both early-stage compound selection and late-stage individualized dosing. Traditional PK model offer mechanistic interpretability but often rely on rigid assumptions, extensive…
Tilo Strutz, Roman Rischke
—The transmission or storage of signals typically involves data compression. The final processing step in compression systems is generally an entropy coding stage, which converts symbols into a bit stream based on their probability distribution. A distinct class of entropy coding methods operates not by mapping input…
Parfenova, Angelina, Marfurt, Andreas + 4 more
This paper investigates the automation of qualitative data analysis, focusing on inductive coding using large language models (LLMs). Unlike traditional approaches that rely on deductive methods with predefined labels, this research investigates the inductive process where labels emerge from the data. The study…
Authors not listed
We present a chemical framework in which adaptive organization is achieved by tuning a gated quantum resonator (adaptive genomic resonator) {driven quantum oscillator} across a driven, dissipative reaction manifold (fitness landscape) {Hamiltonian potential surface}. In this view, catalytic elements set gain and phase…