22 papers · ranked by Valyu relevance
Jillian V. Berry, Bryan M. Tran, Ginny Wu, Zhiqun Tan + 45 more
High-quality neurotypical postmortem human brain tissue is essential but difficult to obtain for constructing comprehensive human brain cell atlases. Here we describe the establishment of UC Irvine’s Brain Procurement Program, a coordinated initiative to collect and process neurotypical donor brains for multiomic…
Carolina Gonzalez-Riano, Silvia Tapia-González, Antonia García, Alberto Muñoz + 2 more
'Alberto Muñoz' 'Javier DeFelipe' 'Coral Barbas'] Understanding the human brain is the ultimate goal in neuroscience, but this is extremely challenging in part due to the fact that brain tissue obtained from autopsy is practically the only source of normal brain tissue and also since changes at different levels of…
Karolina Dulka, Noémi Lajkó, Kálmán Nacsa, Karoly Gulya + 2 more
'Ivana De la Serna' 'Che-Kun James Shen'] Temporal and spatial epigenetic modifications in the brain occur during ontogenetic development, pathophysiological disorders, and aging. When epigenetic marks, such as histone methylations, in brain autopsies or biopsy samples are studied, it is critical to understand their…
Anton Sdobnov, Alexander Bykov, Gennadi Piavchenko, Vassiliy Tsytsarev + 1 more
We use Laser Speckle Contrast Imaging (LSCI) for transcranial visualization of cerebral blood flow microcirculation in mice during and after cardiac arrest. Analyzing time series of LSCI images, we observed temporal variations in blood flow distribution across the brain surface for up to several hours postmortem.…
Sujan C. Das, Danli Chen, W. Brandon Callor, Eric Christensen + 2 more
Most cognitive and psychiatric disorders are thought to be disorders of the synapse, yet the precise synapse defects remain unknown. Because synapses are highly specialized anatomical structures, defects in synapse formation and function can often be observed as changes in micro-scale neuroanatomy. Unfortunately, few…
Yuto Uchida, Hyeong-Geol Shin, Laura Gomez-Isaza, Juan C. Troncoso + 11 more
The human cerebral cortex consists of anatomically and functionally distinct regions defined by heterogeneous cytoarchitectonic, myelin-related microstructural organization. Quantitative magnetic resonance imaging (MRI) provides a noninvasive framework to resolve subtle regional differences across the cortical mantle.…
Weiya Ma, Yashar Zeighami, Mahsa Dadar
Immunohistochemical (IHC) and histochemical (HC) staining is widely used for human brains postfixed in formalin for years and decades. Understanding the effect of prolonged post-fixation, postmortem interval (PMI) and age on these staining procedures is important for interpreting their outcomes, thus improving…
Eve-Marie Frigon, Amy Gérin-Lajoie, Mahsa Dadar, Denis Boire + 1 more
2.1### Population We used a convenience sample of 42 human brains (NBF: N = 12; SSS: N = 13; AFS: N = 17) from our body donation program (Université du Québec à Trois-Rivières, Canada) as well as the Douglas-Bell Canada Brain Bank (Douglas Mental Health University Institute, McGill University, Montréal, Canada). Prior…
Pulkit Khandelwal, Michael Tran Duong, Shokufeh Sadaghiani, Sydney Lim + 32 more
'Sydney Lim' 'Amanda E Denning' 'Eunice Chung' 'Sadhana Ravikumar' 'Sanaz Arezoumandan' 'Claire M. Peterson' 'Madigan L. Bedard' 'Noah Capp' 'Ranjit Ittyerah' 'Elyse Migdal' 'Grace Choi' 'Emily Kopp' 'Bridget Loja' 'Eusha Hasan' 'Jiacheng Li' 'Karthik Prabhakaran' 'Gabor Mizsei' 'M. Gabrielyan' 'Theresa Schuck'…
Go Shirota, Wataru Gonoi, Masanori Ishida, Hidemi Okuma + 7 more
'Yukako Shintani' 'Hiroyuki Abe' 'Yutaka Takazawa' 'Masako Ikemura' 'Masashi Fukayama' 'Kuni Ohtomo' 'Jean-Claude Baron'] The purpose of this study was to evaluate the brain by postmortem computed tomography (PMCT) versus antemortem computed tomography (AMCT) using brains from the same patients. We studied 36…
Maryana Alegro, Eduardo Joaquim Lopes Alho, Maria da Graça Morais Martin, Lea Teneholz Grinberg + 4 more
'Maria da Graça Morais Martin' 'Lea Teneholz Grinberg' 'Helmut Heinsen' 'Roseli de Deus Lopes' 'Edson Amaro' 'Lilla Zöllei'] Abstract. Although the latest advances in MRI technology have allowed the acquisition of higher resolution images, reliable delineation of cytoarchitectural or subcortical nuclei boundaries is…
Macy Garrood, Alicia Keberle, Allison Sowa, William Janssen + 5 more
The ultrastructural analysis of postmortem brain tissue can provide important insights into cellular architecture and disease-related changes. For example, connectomics studies offer a powerful emerging approach for understanding neural circuit organization. However, electron microscopy (EM) data is difficult to…
Ryuta Mizutani, Rino Saiga, Akihisa Takeuchi, Kentaro Uesugi + 15 more
'Yasuko Terada' 'Yoshio Suzuki' 'Vincent De Andrade' 'Francesco De Carlo' 'Susumu Takekoshi' 'Chie Inomoto' 'Naoya Nakamura' 'Itaru Kushima' 'Shuji Iritani' 'Norio Ozaki' 'Soichiro Ide' 'Kazutaka Ikeda' 'Kenichi Oshima' 'Masanari Itokawa' 'Makoto Arai'] Ryuta Mizutani1 *, Rino Saiga1 , Akihisa Takeuchi2 , Kentaro…
Beata Toczylowska, Piotr Kalinowski, Agata Kacka-Piotrowska, Paulina Duda + 3 more
'Paulina Duda' 'Michał Grąt' 'Elzbieta Zieminska' 'Ilya A. Khodov'] The aim of this study was to gain insight into the biochemical status of cerebrospinal fluid in the presence of brain death in life-supported patients. The biochemical status was determined via in vitro NMR spectroscopy of cerebrospinal fluid (CSF)…
Benedict Breitling, Robert Brunkhorst, Marcel Verhoff, Christian Foerch + 1 more
This prospective study was undertaken between January 2015 and April 2016 at the Department of Neurology and the Department of Forensic Medicine, Hospital of the Goethe University, Frankfurt am Main, Germany. All procedures performed in studies involving human participants were in accordance with the ethical standards…
Peter Coppola
How subjective experience (i.e., consciousness) arises out of objective material processes has been called the hard problem. The neuroscience of consciousness has set out to find the sufficient conditions for consciousness and theoretical and empirical endeavours have placed a particular focus on the cortex and…
Xuehai Wu, Jiaying Zhang, Zaixu Cui, Weijun Tang + 11 more
'Jin Hu' 'Jianhong Zhu' 'Liangfu Zhou' 'Yao Zhao' 'Lu Lu' 'Gang Chen' 'Georg Northoff' 'Gaolang Gong' 'Ying Mao' 'Yong He'] This study aimed to identify white matter (WM) deficits underlying the loss of consciousness in disorder of consciousness (DOC) patients using Diffusion Tensor Imaging (DTI) and to demonstrate the…
Mateusz Trokielewicz, Adam Czajka, Piotr Maciejewicz
—This paper presents a comprehensive study of postmortem human iris recognition carried out for 1,200 nearinfrared and 1,787 visible-light samples collected from 37 deceased individuals kept in the mortuary conditions. We used four independent iris recognition methods (three commercial and one academic) to analyze…
Eliane Meuwly, Maria Feldmann, Walter Knirsch, Michael von Rhein + 7 more
'Kelly Payette' 'Hitendu Dave' 'Ruth Tuura' 'Raimund Kottke' 'Cornelia Hagmann' 'Beatrice Latal' 'András Jakab'] Eliane Meuwly1 and Maria Feldmann1**, Walter Knirsch2,3 , Michael von Rhein1 , Kelly Payette4 , Hitendu Dave5 , Ruth O'Gorman Tuura3,4 , Raimund Kottke6 , Cornelia Hagmann7 , Beatrice Latal1, 3† and András…
Wojciech Michno, Patrick Wehrli, Srinivas Koutarapu, Christian Marsching + 9 more
Understanding of Alzheimer’s disease (AD) pathophysiology, requires molecular assessment of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the surrounding microenvironment. Here, neuronal lipids are particularly of interest as these are implicated in pathological- and neurodegenerative…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…