18 papers · ranked by Valyu relevance
Jillian V. Berry, Bryan M. Tran, Ginny Wu, Zhiqun Tan + 45 more
High-quality neurotypical postmortem human brain tissue is essential but difficult to obtain for constructing comprehensive human brain cell atlases. Here we describe the establishment of UC Irvine’s Brain Procurement Program, a coordinated initiative to collect and process neurotypical donor brains for multiomic…
Joy Mojumder, Yuan-Chiao Lu, Alexa M. Diano, Ahmed A. Alshareef + 5 more
Traumatic brain injury (TBI) is a serious health condition that can cause neurological dysfunction to varying degrees depending on the nature of the mechanical insult. In biomechanical studies of TBI under high loading conditions, post-mortem human subjects (PMHS) are often used since ethical concerns prohibit such…
Pulkit Khandelwal, Michael Tran Duong, Lisa M. Levorse, Winifred Trotman + 27 more
The impact of different neuropathologies on deep brain structures remains to be understood. Here, we distinguish subcortical and limbic volumetry in neurodegenerative diseases involving p-tau, α-synuclein and TDP-43. We acquired neuropathological measures and brain segmentations from postmortem analysis of 132 donors…
Eve-Marie Frigon, Weiya Ma, Cecilia Tremblay, Dominique Mirault + 6 more
Postmortem human brains stored in brain banks are important research resources to study the mechanisms underlying normal brain functions as well as various neurodegenerative disorders. Immunohistochemical (IHC) and histochemical (HC) staining have been used to examine human brains fixed in neutral-buffered formalin…
Aurelia Song, Anna LaVergne, Borys Wróbel
Building a high-fidelity computational model of the whole human brain will require preservation of the ultrastructure at the level of the entire organ, post-mortem. For such a model to reflect as closely as possible the brain in the living state, artifacts that arise during both the agonal phase and the postmortem…
Brian H. Kopell, Deepak A. Kaji, Lora E. Liharska, Eric Vornholt + 33 more
Due to the unavailability of living human brain tissue for molecular research, postmortem brain samples are currently the standard tissue source for molecular studies of the human brain. The Living Brain Project (LBP) was designed to test the assumption that the postmortem brain is an accurate molecular representation…
Yuto Uchida, Hyeong-Geol Shin, Laura Gomez-Isaza, Juan C. Troncoso + 11 more
The human cerebral cortex consists of anatomically and functionally distinct regions defined by heterogeneous cytoarchitectonic, myelin-related microstructural organization. Quantitative magnetic resonance imaging (MRI) provides a noninvasive framework to resolve subtle regional differences across the cortical mantle.…
Ran Barzilay, Katherin Sudol, Nikolaos P. Daskalakis, Maura B. Dupont + 1 more
Suicide is the second leading cause of death for American adolescents and young adults and is transdiagnostic. Suicide risk is impacted by genetic and both distal and proximal environmental factors, particularly stress exposures. This review encompasses the past 10 years of research comparing biological measures…
Jacob Berardinelli, Jr-Jiun Liou, Nadim Farhat, Jinghang Li + 10 more
Postmortem imaging at ultrahigh field strengths, such as 7 Tesla (7T) magnetic resonance imaging (MRI), enables unprecedented visualization of fine brain structures and pathology. However, precise registration between MRI and histology is often compromised by tissue deformation and lack of standardized tools for…
Andrea Hill, Fenglai Xiao, Maria Thom, David Maudgil + 6 more
1. SUDEP is a major cause of epilepsy-related death, yet validated biological risk markers remain scarce. 2. Postmortem MRI showed relative hippocampal and amygdala volume preservation or enlargement in SUDEP cases. 3. These structural findings complement clinical risk factors, mainly frequent GTCS and sleeping alone.…
Andrew T. McKenzie, Alicia Keberle, Andria Slaughter, Macy Garrood + 5 more
Expansion microscopy (ExM) physically enlarges biological specimens to enable ultrastructural imaging with conventional fluorescence microscopes. However, its performance in postmortem human brain tissue is unclear. Here, we evaluated how a previously established ExM protocol performs on cortical tissue from eight…
Medardo Aguirre, Jonathan Williams-Ramirez, Dina Zemlyanker, Xiaoling Hu + 12 more
- 1 Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, United States 2 Federal Institute of Technology (ETH), Zurich, Switzerland - 3 BioRepository and Integrated Neuropathology (BRaIN) Laboratory and Precision Neuropathology Core, University of Washington School of…
Alexander Muacevic, John R Adler, Toshal D Wankhade, Chaitanya Mittal + 3 more
Introduction: Head injury is a major cause of morbidity and mortality worldwide, and accurate assessment of traumatic head injuries is important for both clinical management and medicolegal investigations. Computed tomography (CT) is routinely used for the evaluation of head injuries in living patients, whereas…
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Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Authors not listed
The amyloid-β (Aβ) peptides are crucial biomarkers for the diagnosis of Alzheimer's disease (AD), the most common neurodegenerative disease. The high diversity of the Aβ family provides a significant challenge for recognizing various Aβ forms, which may differ by a single amino acid or a post-translational…
Jin‐Hao Yang, Shaojiong Zhou, Zhibin Wang, Jiahua Xu + 13 more
Jinhao Yang a,b,1 , Shaojiong Zhou c,1 , Zhibin Wang c , Jiahua Xu a,b , Jia Cheng a,b , Zhouqian Yin a,b , Tao Wei c , Chaofan Geng c , Xiaoduo Liu c , Xiang Lia,b , Xiaoyu Zhou a,b , Kun Lid,e , Ruolei Gu f,g , Raymond Dolan a,h,i, Yi Tang c,j,\ & Yunzhe Liu a,b,\
Nicolas Elbaz, Valérie Biran, Chloé Ghozland, Laurie Devisscher + 9 more
- 1 Service d'Imagerie Pédiatrique, Hôpital Robert-Debré, AP-HP Paris, Université Paris-Cité - 2 Service de réanimation et pédiatrie néonatales, Hôpital Robert-Debré, AP-HP Paris, Université Paris-Cité - 3 Université Paris-Cité, Inserm U1141, NeuroDiderot, F-75019 Paris - 4 Université Paris-Saclay, CEA, NeuroSpin…
Adam M. Saunders, Michael E. Kim, Gaurav Rudravaram, Lucas W. Remedios + 7 more
a Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA; b Department of Computer Science, Vanderbilt University, Nashville, TN, USA; c Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; d Publicis Sapient, Arlington, VA, USA; e Department of…