26 papers · ranked by Valyu relevance
Ricardo J. Pais, Pietro Pinoli, Anna Bernasconi
Clinical bioinformatics is a newly emerging field that applies bioinformatics techniques for facilitating the identification of diseases, discovery of biomarkers, and therapy decision. Mathematical modelling is part of bioinformatics analysis pipelines and a fundamental step to extract clinical insights from genomes…
Daniel S. Hain, Roman Jurowetzki
Recent years have seen a substantial development of quantitative methods, mostly led by the computer science community with the goal to develop better machine learning application, mainly focused on predictive modeling. However, economic, management, and technology forecasting research has up to now been hesitant to…
Addisu Jember Zeleke, Pierpaolo Palumbo, Paolo Tubertini, Rossella Miglio + 1 more
'Rossella Miglio' 'Lorenzo Chiari'] Objective This study aims to develop and compare different models to predict the Length of Stay (LoS) and the Prolonged Length of Stay (PLoS) of inpatients admitted through the emergency department (ED) in general patient settings. This aim is not only to promote any specific model…
Alicja Wolny–Dominiak, Tomasz Żądło
strategy Authors: ['Alicja Wolny–Dominiak' 'Tomasz Żądło'] This paper addresses the topic of choosing a prediction strategy when using parametric or nonparametric regression models. It emphasizes the importance of ex ante prediction accuracy, ensemble approaches, and forecasting not only the values of the dependent…
Banne Nemeth, Mark J.R. Smeets, Suzanne C. Cannegieter, Maarten van Smeden
'Maarten van Smeden'] Clinical prediction modeling has become an increasingly popular domain of venous thromboembolism research in recent years. Prediction models can help healthcare providers make decisions regarding starting or withholding therapeutic interventions, or referrals for further diagnostic workup, and can…
Malte Schierholz
A common approach in forecasting problems is to estimate a least-squares regression (or other statistical learning models) from past data, which is then applied to predict future outcomes. An underlying assumption is that the same correlations that were observed in the past still hold for the future. We propose a model…
Authors not listed
Background: Janus Kinase 2 (JAK2) is a key kinase in cellular signal transduction. Its abnormal activation is closely related to various myeloproliferative neoplasms and inflammatory diseases. Developing selective JAK2 inhibitors is an important direction in drug discovery. Accurate prediction of compound inhibitory…
Amir Sorayaie Azar, Samin Babaei Rikan, Amin Naemi, Jamshid Bagherzadeh Mohasefi + 3 more
'Jamshid Bagherzadeh Mohasefi' 'Habibollah Pirnejad' 'Matin Bagherzadeh Mohasefi' 'Uffe Kock Wiil'] Background Ovarian cancer is the fifth leading cause of mortality among women in the United States. Ovarian cancer is also known as forgotten cancer or silent disease. The survival of ovarian cancer patients depends on…
Lorena Hafermann, Nadja Klein, Geraldine Rauch, Michael Kammer + 2 more
There is an increasing interest in machine learning (ML) algorithms for predicting patient outcomes, as these methods are designed to automatically discover complex data patterns. For example, the random forest (RF) algorithm is designed to identify relevant predictor variables out of a large set of candidates. In…
Roemer J Janse, Ameen Abu-Hanna, Iacopo Vagliano, Vianda S Stel + 5 more
'Kitty J Jager' 'Giovanni Tripepi' 'Carmine Zoccali' 'Friedo W Dekker' 'Merel van Diepen'] Title: ABSTRACT An artificial intelligence boom is currently ongoing, mainly due to large language models, leading to significant interest in artificial intelligence and subsequently also in machine learning (ML). One area where…
Joshua P. Jahner, C. Alex Buerkle, Dustin G. Gannon, Eliza M. Grames + 11 more
The proliferation of biological data with large numbers of samples and many dimensions is kindling hope that life scientists will be able to fit statistical and machine learning models that are highly predictive and interpretable. However, large biological data sets are commonly burdened with an inherent trade-off…
Prashanth Athri, Vidhya Murali, Pradyumna Y Muralidhar, Cassandra Königs + 4 more
- 1. Department of Computer Science and Engineering, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Bengaluru, India - 2. PES Center for Pattern Recognition, Department of Computer Science and Engineering, PES University, Bengaluru, India - 3. Bioinformatics and Medical Informatics, Bielefeld University…
Fuzhan Rahmanian, Robert M. Lee, Dominik Linzner, Kathrin Michel + 4 more
Predicting and monitoring battery life early and across chemistries is a significant challenge due to the plethora of degradation paths, form factors, and electrochemical testing protocols. Existing models typically translate poorly across different electrode, electrolyte, and additive materials, mostly require a fixed…
John Mark Agosta, Robert F. Horton
With the explosion of applications of Data Science, the field is has come loose from its foundations. This article argues for a new program of applied research in areas familiar to researchers in Bayesian methods in AI that are needed to ground the practice of Data Science by borrowing from AI techniques for model…
Areen Arabiat, Hamza Abu Owida, Suhaila Abuowaida, Nawaf Alshdaifat + 2 more
This study emphasizes the potential of computational techniques in cancer risk assessment, highlighting opportunities for specific and data-driven healthcare solutions. It examines the use of artificial intelligence (AI), machine learning (ML), and deep learning (DL) approaches to improve cancer risk assessment using a…
Gonçalo Mateus, Cláudia Soares, João Leitão, António Rodrigues
The use of machine learning for time series prediction has become increasingly popular across various industries thanks to the availability of time series data and advancements in machine learning algorithms. However, traditional methods for time series forecasting rely on pre-optimized models that are ill-equipped to…
Authors not listed
Machine learning holds significant promise for accelerating biomarker discovery in clinical proteomics, yet its real-world impact remains limited by widespread methodological pitfalls and unrealistic expectations. In this perspective, we critically examine the integration of machine learning into clinical proteomics…
Raquel Costa, Bruno de Sousa, Thomas Kneib, Rui Martins + 1 more
Clinical prediction models play a crucial role in advancing personalized care for mental health disorders, providing essential insights for diagnosis, prognosis and intervention planning. This work examines the current methodological approaches used to develop such models, emphasizing their application to mental health…
Rajeev Jaundoo, Jack A. Tuszynski, Travis J.A. Craddock
Interactions between drugs can lead to adverse side effects for patients taking combination therapies to treat complex diseases such as cancer. Knowledge of drug-action towards a receptor would allow these drug-drug interactions to be predicted, and in this study, we trained a total of 5 different machine learning…
Michal Bozděch
Not only in sports is a neural network the most used type of artificial intelligence. With software development, anyone can create a neural network model, but little is known about how to prepare the data and how to set up the model algorithms to their maximum performance. For these reasons, this study aims to…
Tilda Herrgårdh, Elizabeth Hunter, Kajsa Tunedal, Håkan Örman + 5 more
One of the more interesting ideas for achieving personalized, preventive, and participatory medicine is the concept of a digital twin. A digital twin is a personalized computer model of a patient. So far, digital twins have been constructed using either mechanistic models, which can simulate the trajectory of…
Authors not listed
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two important targets in current drug discovery, mainly due to the COVID-19 pandemic and the MERS-CoV outbreaks in recent years. An important target of both SARS-CoV-2 and MERS-CoV is the main…
Authors not listed
The use of hybrid models, combing mechanistic and machine learning (ML), has emerged as a promising approach, contributing to the development of Industry 4.0. This work presents a hybrid model that forecasts minibioreactor (MBR) production runs of mammalian cell culture recombinant for monoclonal antibodies (mAbs)…
David Quesada, Pedro Larrañaga, Concha Bielza
When we face patients arriving to a hospital suffering from the effects of some illness, one of the main problems we can encounter is evaluating whether or not said patients are going to require intensive care in the near future. This intensive care requires allotting valuable and scarce resources, and knowing…
Husam Abdulnabi, J. Timothy Westwood
A quantitative measurement can have variation, referred to here as measurement variation, which is a probability distribution. Machine Learning models typically produce a prediction corresponding to the mode of the measurement variation. The Deviation Error is a novel metric, described here, to assess predictions that…
Anni S. Halkola, Kaisa Joki, Tuomas Mirtti, Marko M. Mäkelä + 2 more
In many real-world applications, such as those based on patient electronic health records, prognostic prediction of patient survival is based on heterogeneous sets of clinical laboratory measurements. To address the trade-off between the predictive accuracy of a prognostic model and the costs related to its clinical…