20 papers · ranked by Valyu relevance
Ruth Benavides-Piccione, Blazquez-Llorca, Asta Kastanauskaite, Isabel Fernaud + 2 more
The basic building block of the cerebral cortex, the pyramidal cell, has been shown to be characterized by a markedly different dendritic structure among layers, cortical areas, and species. Functionally, differences in the structure of their dendrites and axons are critical in determining how neurons integrate…
Alberto A. Rasia-Filho, Kétlyn T. Knak Guerra, Carlos Escobar Vásquez, Aline Dall’Oglio + 3 more
Human cortical and subcortical areas integrate emotion, memory, and cognition when interpreting various environmental stimuli for the elaboration of complex, evolved social behaviors. Pyramidal neurons occur in developed phylogenetic areas advancing along with the allocortex to represent 70-85% of the neocortical gray…
Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen + 4 more
'Liang Zhang' 'Peter L. Carlen' 'Shreejoy J. Tripathy' 'Taufik A. Valiante'] In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To characterize this potential distinctiveness, we use in…
Alberto Sanchez-Aguilera, Diek W. Wheeler, Teresa Jurado-Parras, Manuel Valero + 8 more
'Manuel Valero' 'Miriam S. Nokia' 'Elena Cid' 'Ivan Fernandez-Lamo' 'Nate Sutton' 'Daniel García-Rincón' 'Liset M. de la Prida' 'Giorgio A. Ascoli' 'Thomas Klausberger'] Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This…
Homeira Moradi Chameh, Lihua Wang, Scott Rich, Liang Zhang + 3 more
In the human neocortex, coherent theta oscillations between superficial and deep cortical layers are driven by deep layer neurons, suggesting distinct intrinsic electrophysiological properties of neurons across cortical layers. Here, we used in vitro whole-cell recordings to characterize pyramidal cells in layer 2/3…
Jochen Kerdels, Gabriele Peters
About a decade ago grid cells were discovered in the medial entorhinal cortex of rat. Their peculiar firing patterns, which correlate with periodic locations in the environment, led to early hypothesis that grid cells may provide some form of metric for space. Subsequent research has since uncovered a wealth of new…
Nick Y. Larsen, Xixia Li, Xueke Tan, Gang Ji + 7 more
'Grazyna Rajkowska' 'Jesper Møller' 'Ninna Vihrs' 'Jon Sporring' 'Fei Sun' 'Jens R. Nyengaard'] Techniques involving three-dimensional (3D) tissue structure reconstruction and analysis provide a better understanding of changes in molecules and function. We have developed AutoCUTS-LM, an automated system that allows the…
Anh Duong Vo, Elisabeth Abs, Pau Vilimelis Aceituno, Benjamin F. Grewe + 1 more
'Benjamin F. Grewe' 'Katharina A. Wilmes'] Recent research has revealed the unique functionality of cortical pyramidal cell subtypes, namely intratelencephalic neurons (IT) and pyramidal-tract neurons (PT). How these two populations interact with each other to fulfill their functional roles remains poorly understood.…
Данко Георгиев, Stefan K. Kolev, Eliahu Cohen, James F. Glazebrook
The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information…
Andreas D. Christoffersen, Jesper Møller, Heidi S. Christensen
For modelling the location of pyramidal cells in the human cerebral cortex we suggest a hierarchical point process in R 3 that exhibits anisotropy in the form of cylinders extending along the z-axis. The model consists first of a generalised shot noise Cox process for the xy-coordinates, providing cylindrical clusters…
Thomas Crockett, Nathaniel Wright, Stephen Thornquist, Michael Ariel + 2 more
'Ralf Wessel' 'Maurice J. Chacron'] A detailed inventory of the constituent pieces in cerebral cortex is considered essential to understand the principles underlying cortical signal processing. Specifically, the search for pyramidal neuron subtypes is partly motivated by the hypothesis that a subtype-specific division…
Julie Jézéquel, Giuseppe Condomitti, Tim Kroon, Fursham Hamid + 5 more
In the mammalian neocortex, excitatory pyramidal cells are assembled into distinct subnetworks, which project to different brain areas. GABAergic interneurons were long thought to connect promiscuously and extensively to pyramidal neurons, but recent evidence supports the existence of a cell type-specific inhibitory…
Tomofumi Oga, Guy N. Elston, Ichiro Fujita
Pyramidal cells in the primate cerebral cortex, particularly those in layer III, exhibit regional variation in both the time course and magnitude of postnatal growth and pruning of dendrites and spines. Less is known about the development of pyramidal cell dendrites and spines in other cortical layers. Here we studied…
Mototaka Suzuki, Jaan Aru
Technological advances in the past decades have begun to enable neuroscientists to address fundamental questions about consciousness in an unprecedented way. Here we review remarkable recent progress in our understanding of cellular-level mechanisms of conscious processing in the brain. Of particular interest are the…
Joram Keijser, Henning Sprekeler
Cortical inhibitory interneurons form a broad spectrum of subtypes. This diversity suggests a division of labour, in which each cell type supports a distinct function. In the present era of optimisation-based algorithms, it is tempting to speculate that these functions were the evolutionary or developmental driving…
Niklas Schwarz, Betül Uysal, Marc Welzer, Jacqueline C Bahr + 13 more
'Nikolas Layer' 'Heidi Löffler' 'Kornelijus Stanaitis' 'Harshad PA' 'Yvonne G Weber' 'Ulrike BS Hedrich' 'Jürgen B Honegger' 'Angelos Skodras' 'Albert J Becker' 'Thomas V Wuttke' 'Henner Koch' 'Inna Slutsky' 'Eve Marder'] Most of our knowledge on human CNS circuitry and related disorders originates from model…
Jean Simonnet, Mérie Nassar, Federico Stella, Ivan Cohen + 4 more
Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here we examine how thalamic afferents…
Gabriele Scheler, Jean‐Marc Fellous
Recent electrophysiological experiments have shown that dopamine (D1) modulation of pyramidal cells in prefrontal cortex reduces spike frequency adaptation and enhances NMDAtransmission. Using four models, from multicompartmental to integrate and fire, we examine the effects of these modulations on sustained (delay)…
Kristina D. Micheva, Marianna Kiraly, Marc M. Perez, Daniel V. Madison
Parvalbumin-containing (PV+) basket cells are specialized cortical interneurons that regulate the activity of local neuronal circuits with high temporal precision and reliability. PV+ interneuron disfunction is associated with numerous psychiatric disorders, including schizophrenia and autism spectrum disorders. To…
Authors not listed
Scanning ion conductance microscopy (SICM) offers non-contact, label-free imaging of live cells with nanometer-scale resolution. However, its conventional imaging mode is inherently slow due to repeated vertical scanning, limiting temporal resolution and causing inertial issues. Here, we present Scanning Counter Ion…