22 papers · ranked by Valyu relevance
William G. Hill
Quantitative genetics, or the genetics of complex traits, is the study of those characters which are not affected by the action of just a few major genes. Its basis is in statistical models and methodology, albeit based on many strong assumptions. While these are formally unrealistic, methods work. Analyses using dense…
Jeremy J. Berg, Graham Coop
Adaptation in response to selection on polygenic phenotypes may occur via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed knowledge about the specific loci underlying polygenic traits has begun to emerge from…
Rex Bernardo
The goals of quantitative genetics differ according to its field of application. In plant breeding, the main focus of quantitative genetics is on identifying candidates with the best genotypic value for a target population of environments. Keeping quantitative genetics current requires keeping old concepts that remain…
Erik C Andersen, Matthew V Rockman, M -A Félix
Over the last 20 years, studies of Caenorhabditis elegans natural diversity have demonstrated the power of quantitative genetic approaches to reveal the evolutionary, ecological, and genetic factors that shape traits. These studies complement the use of the laboratory-adapted strain N2 and enable additional discoveries…
Susan E. Johnston, Nancy Chen, Emily B. Josephs
A key goal in studies of ecology and evolution is understanding the causes of phenotypic diversity in nature. Most traits of interest, such as those relating to morphology, life-history, immunity and behaviour are quantitative, and phenotypic variation is driven by the cumulative effects of genetic and environmental…
David J. Cutler, Kiana Jodeiry, Andrew J. Bass, Michael P. Epstein
In this the first of an anticipated four paper series, fundamental results of quantitative genetics are presented from a first principles approach. While none of these results are in any sense new, they are presented in extended detail to precisely distinguish between definition and assumption, with a further emphasis…
Jonathan Flint
Crow’s book is not the only textbook on quantitative genetics. I might have started with Douglas Falconer’s classic Introduction to Quantitative Genetics (1960) (no mention of population genetics there!) . I came across Falconer’s book (in the excellent edition that has Trudy Mackay as a co-author ) later. However, by…
Tim Beissinger, Jochen Kruppa, David Cavero, Ngoc-Thuy Ha + 2 more
Important traits in agricultural, natural, and human populations are increasingly being shown to be under the control of many genes that individually contribute only a small proportion of genetic variation. However, the majority of modern tools in quantitative and population genetics, including genome wide association…
Diethard Tautz, Luisa F Pallares, Leif Andersson, Neda Barghi + 20 more
The long-standing notion that genotypes map to phenotypes through simple one gene-one trait relationships continues to shape both research in the life sciences and public understanding, with implications for policy and funding priorities. Yet this paradigm is increasingly recognized as inadequate for explaining…
Armita Nourmohammad, Torsten Held, Michael Lässig
Molecular traits, such as gene expression levels or protein binding affinities, are increasingly accessible to quantitative measurement by modern high-throughput techniques. Such traits measure molecular functions and, from an evolutionary point of view, are important as targets of natural selection. We review recent…
Elise Tourrette, Olivier Martin
During the founding of the field of quantitative genetics, Fisher formulated in 1918 his "infinitesimal model" that provided a novel mathematical framework to describe the Mendelian transmission of quantitative traits. If the infinitely many genes in that model are assumed to segregate independently during…
Carl Nettelblad, Behrang Mahjani, Sverker Holmgren
We present a new computational scheme that enables efficient and reliable Quantitative Trait Loci (QTL) scans for experimental populations. Using a standard brute-force exhaustive search effectively prohibits accurate QTL scans involving more than two loci to be performed in practice, at least if permutation testing is…
Mark G. Sterken, Roel P. J. Bevers, Rita J. M. Volkers, Joost A. G. Riksen + 2 more
The study of expression quantitative trait loci (eQTL) using natural variation in inbred populations has yielded detailed information about the transcriptional regulation of complex traits. Studies on eQTL using recombinant inbred lines (RILs) led to insights on local and distant regulatory loci of transcript…
B Ashraf, DC Hunter, C Bérénos, PA Ellis + 4 more
Genomic prediction, the technique whereby an individual’s genetic component of their phenotype is estimated from its genome, has revolutionised animal and plant breeding and medical genetics. However, despite being first introduced nearly two decades ago, it has hardly been adopted by the evolutionary genetics…
Chiann-Ling C. Yeh, Andreas Tsouris, Joseph Schacherer, Maitreya J. Dunham
How natural variation affects phenotype is difficult to determine given our incomplete ability to deduce the functional impact of the polymorphisms detected in a population. Although current computational and experimental tools can predict and measure allele function, there has previously been no assay that does so in…
Jeremy J. Berg, Graham Coop
Adaptation in response to selection on polygenic phenotypes occurs via subtle allele frequencies shifts at many loci. Current population genomic techniques are not well posed to identify such signals. In the past decade, detailed knowledge about the specific loci underlying polygenic traits has begun to emerge from…
S. J. Anderson, S. D. Côté, J. H. Richard, A.B.A. Shafer
Characterization of the complex genomic architecture underlying quantitative traits can provide valuable insights into the study, conservation, and management of natural populations. This is particularly true for fitness-related traits such as body size and male ornamentation in mammals because as indicators of quality…
Masaaki Sudo, Masahiro Osakabe
PCR techniques, both quantitative (qPCR) and non-quantitative, have been used to estimate allele frequency in a population. However, the labor required to sample more individuals and handle each sample makes it difficult to quantify rare mutations, such as pesticide-resistance genes at the early stages of resistance…
Authors not listed
Large-scale de novo nucleic acid synthesis is a powerful tool enabling researchers to better understand and engineer biological systems. Fields ranging from genomics to nucleic acid therapeutics to synthetic biology make use of high-throughput experimental approaches requiring access to large pools or libraries of DNA…
Authors not listed
The COVID-19 pandemic underscored the global need for rapid, sensitive, and multiplexed diagnostic assays for viral detection. RT-qPCR remains the standard for SARS-CoV-2 RNA detection, while antigen-based protein assays provide faster, though less sensitive, alternatives. Here, we present a novel diagnostic platform…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Authors not listed
State of the art in silico ∆∆G predictions for antibody-antigen complexes achieve an accuracy of ±1 kcal/mol. While this is sufficient for high throughput screening or affinity maturation, it is insufficient for assessing the criticality of post-translational modifications (PTMs) during clinical development. PTMs that…