27 papers · ranked by Valyu relevance
Oliver J. Gurney-Champion, Faisal Mahmood, Marcel van Schie, Robert Julian + 5 more
'Robert Julian' 'Ben George' 'Marielle E.P. Philippens' 'Uulke A. van der Heide' 'Daniela Thorwarth' 'Kathrine R. Redalen'] Title: Highlights 1. • Quantitative imaging (QI) is promising for radiotherapy. 2. • The key points from the QI track of the 2nd ESTRO Physics Workshop are discussed. 3. • QI biomarkers may be…
Wonmo Sung
The Special Issue of Tomography is a collection of articles focused on the quantitative imaging methods in clinical oncology. Cancer is a leading cause of death. The gene mutation in cancer cells accelerates cell division or inhibits normal controls. As the tumor grows rapidly, it can disturb proper organ function. If…
Lori R. Arlinghaus, Xia Li, Mia Levy, David Smith + 3 more
The current state-of-the-art assessment of treatment response in breast cancer is based on the response evaluation criteria in solid tumors (RECIST). RECIST reports on changes in gross morphology and divides response into one of four categories. In this paper we highlight how dynamic contrast-enhanced magnetic…
John C. Dickson, Ian S. Armstrong, Pablo Minguez Gabiña, Ana M. Denis-Bacelar + 5 more
'Ana M. Denis-Bacelar' 'Aron K. Krizsan' 'Jonathan M. Gear' 'Tim Van den Wyngaert' 'Lioe-Fee de Geus-Oei' 'Ken Herrmann'] Title: Abstract Purpose Quantitative SPECT-CT is a modality of growing importance with initial developments in post radionuclide therapy dosimetry, and more recent expansion into bone, cardiac and…
Yan Liu, Huitian Xia, Nancy A. Obuchowski, Richard Laforest + 3 more
Department of Biomedical Engineering, Washington University, St. Louis, MO, USA Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, USA Department of Radiology, University of British Columbia, Vancouver, Canada School of…
Nicolò Lauciello, Giorgio Russo, Alessandro Stefano, Goorak Kwon
Quantitative preclinical imaging enables non-invasive characterization of physiological, molecular, and functional processes providing measurable biomarkers for longitudinal and translational studies. This review systematically analyzes 60 studies published between 2015 and 2025, covering major imaging modalities…
Yoonjae Chung, SeHyun LEE, Hervé Hugonnet, Chulmin Oh + 4 more
Brightfield microscopy is central to wide range of biology, engineering, and histopathology; but is inherently limited to two-dimensional qualitative imaging, systematically investigating three-dimensional (3D) volumetric architecture. Here we introduce quantitative absorption tomography (QAT), a computational approach…
Robert J. Nordstrom
Precision medicine is a healthcare model that seeks to incorporate a wealth of patient information to identify and classify disease progression and to provide tailored therapeutic solutions for individual patients. Interventions are based on knowledge of molecular and mechanistic causes, pathogenesis and pathology of…
Ohyun Kwon, Sean P. Jollota, Adedamola O. Adeniyi, Justin J. Jeffery + 9 more
Autoradiography provides microscale mapping of radionuclide distributions, a promising approach to complement nuclear medicine imaging for small-scale radiopharmaceutical therapy (RPT) research. However, quantitative protocols for β-emitters remain under-established compared to those for α-emitters. In this work, the…
YoungJu Jo, Hyungjoo Cho, Sang‐Yun Lee, Gunho Choi + 3 more
'Hyun‐Seok Min' 'YongKeun Park'] Abstract— Recent advances in quantitative phase imaging (QPI) and artificial intelligence (AI) have opened up the possibility of an exciting frontier. The fast and label-free nature of QPI enables the rapid generation of large-scale and uniform-quality imaging data in two, three, and…
Erik Fredenberg
Spectral imaging is an umbrella term for energy-resolved x-ray imaging in medicine. The technique makes use of the energy dependence of x-ray attenuation to either increase the contrast-to-noise ratio, or to provide quantitative image data and reduce image artefacts by so-called material decomposition. Spectral imaging…
Sayan Kahali, Satya V.V.N. Kothapalli, Xiaojian Xu, Ulugbek S. Kamilov + 1 more
To introduce a Deep-Learning-Based Accelerated and Noise-Suppressed Estimation (DANSE) method for reconstructing quantitative maps of biological tissue cellular-specific, R2t^^ and hemodynamic-specific, R2′ from Gradient-Recalled-Echo (GRE) MRI data with multiple gradient-recalled echoes. DANSE method adapts supervised…
Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, Gabriel Popescu
Tissue refractive index provides important information about morphology at the nanoscale. Since the malignant transformation involves both intra- and inter-cellular changes in the refractive index map, the tissue disorder measurement can be used to extract important diagnosis information. Quantitative phase imaging…
Darina Roitshtain, Lauren Wolbromsky, Evgeny Bal, Hayit Greenspan + 2 more
'Lisa L. Satterwhite' 'Natan T. Shaked'] We present cytometric classification of live healthy and cancer cells by using the spatial morphological and textural information found in the label-free quantitative phase images of the cells. We compare both healthy cells to primary tumor cell and primary tumor cells to…
Thomas Beyer, Luc Bidaut, John Dickson, Marc Kachelriess + 6 more
'Fabian Kiessling' 'Rainer Leitgeb' 'Jingfei Ma' 'Lalith Kumar Shiyam Sundar' 'Benjamin Theek' 'Osama Mawlawi'] Oncological diseases account for a significant portion of the burden on public healthcare systems with associated costs driven primarily by complex and long-lasting therapies. Through the visualization of…
Stephane Chauvie, Lorenzo Nicola Mazzoni, Jim O’Doherty, Emilio Quaia
Imaging biomarkers (IBs) have been proposed in medical literature that exploit images in a quantitative way, going beyond the visual assessment by an imaging physician. These IBs can be used in the diagnosis, prognosis, and response assessment of several pathologies and are very often used for patient management…
Masanori Takabayashi, Hassaan Majeed, Andre Kajdacsy-Balla, Gabriel Popescu
We propose a new intrinsic cancer marker in fixed tissue biopsy slides, which is based on the local spatial autocorrelation length obtained from quantitative phase images. The spatial autocorrelation length in a small region of the tissue phase image is sensitive to the nanoscale cellular morphological alterations and…
Shuyan Zhang, Joseph Yong Xin Cheng, Jian Jun Chua, Malini Olivo
The optical properties of quantum dots were extensively characterized using a hyperspectral fluorescence microscopy system. The system provides a single excitation wavelength in the ultraviolet and 311 emission wavelength channels in the visible. This allows detection of multiple fluorophores (e.g. different quantum…
Authors not listed
A thorough understanding of drug pharmacokinetics and target interaction within complex biological environments is critical for successful drug discovery. Quantitative matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI; qMSI) presents a promising avenue for such investigations. While…
Jonghee Yoon, Kyoohyun Kim, HyunJoo Park, Chulhee Choi + 2 more
'Seongsoo Jang' 'YongKeun Park'] 1Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea 2Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea 3 Department of Laboratory Medicine, University of Ulsan…
Han Sang Park, Hillel Price, Silvia Ceballos, Jen-Tsan Chi + 1 more
Holographic cytometry is introduced as an ultra-high throughput implementation of quantitative phase image based on off-axis interferometry of cells flowing through parallel microfluidic channels. Here, it is applied for characterizing morphological changes of red blood cells during storage under regular blood bank…
Kanda Borgognoni, Bradley Guilliams, Rachel Cohen, Christopher Ackerson
A cloneable NanoParticle (cNP) is an inorganic nanoparticle that is synthesized by a protein. The protein determines the elemental composition, size, morphology, and other properties of the nanoparticle. Here, we describe the use of a cloneable Selenium NanoParticle (cSeNP) as a cloneable imaging contrast agent in…
Authors not listed
The ability to track therapeutic cells is critical for advancing adoptive cell therapy (ACT). Positron emission tomography (PET) offers sensitive and quantitative imaging, yet improved cell radiolabeling strategies are sorely needed. We report a metabolic glycoengineering (MGE) approach that installs azide moieties on…
Richard Edwards, Hannah Greenwood, Timothy Witney
Purpose : (S)-4-(3- 18 F-Fluoropropyl)-ʟ-Glutamic Acid ([ 18 F]FSPG) is a radiolabeled non-natural amino acid that is used for positron emission tomography (PET) imaging of the glutamate/cystine antiporter, system x C - , whose expression is upregulated in many cancer types. To increase the clinical adoption of this…
Yuan Ge, Donal O'Shea
The term “fluorescence” was first proposed nearly two centuries ago, yet its application in Medicine has a relatively brief history of only 70 years. Nowadays, as fluorescence was gradually approaching into more medicine studies, fluorescence image-guided surgery has become the new arena for this technology. It allows…
Ryosuke Ota, Sun Il Kwon, Eric Berg, Fumio Hashimoto + 6 more
'Izumi Ogawa' 'Y. Tamagawa' 'T. Omura' 'Tomoyuki Hasegawa' 'Simon R. Cherry'] Abstract: Positron emission tomography, like many other tomographic imaging modalities, relies on an image reconstruction step to produce cross-sectional images from projection data. Detection and localization of the back-to-back annihilation…
Rananjaya Gamage, Bradley Smith
Indocyanine Blue (ICB) is the deep-red, pentamethine analogue of the widely used clinical near-infrared heptamethine cyanine dye, Indocyanine Green (ICG). The two fluorophores have the same number of functional groups and molecular charge and vary only by a single vinylene unit in the polymethine chain which produces a…