26 papers · ranked by Valyu relevance
J. Gambini, M. Inglés, G. Olaso, R. Lopez-Grueso + 7 more
'L. Gimeno-Mallench' 'C. Mas-Bargues' 'K. M. Abdelaziz' 'M. C. Gomez-Cabrera' 'J. Vina' 'C. Borras'] Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by…
Betul Catalgol, Saime Batirel, Yavuz Taga, Nesrin Kartal Ozer
Resveratrol is a polyphenol that plays a potentially important role in many disorders and has been studied in different diseases. The research on this chemical started through the “French paradox,” which describes improved cardiovascular outcomes despite a high-fat diet in French people. Since then, resveratrol has…
Shraddha D. Rege, Thangiah Geetha, Gerald D. Griffin, Tom L. Broderick + 1 more
'Tom L. Broderick' 'Jeganathan Ramesh Babu'] Alzheimer’s disease is a chronic neurodegenerative disorder characterized by a progressive loss of cognitive and behavioral abilities. Extracellular senile plaques and intracellular neurofibrillary tangles are hallmarks of AD. Researchers aim to analyze the molecular…
Łukasz Kogut, Czesław Puchalski, Danuta Katryńska, Grzegorz Zaguła + 1 more
Background/Objectives: Resveratrol is a multi-target polyphenolic stilbene widely studied for its antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, immunomodulatory and anticancer properties. This review summarizes current evidence on its molecular mechanisms, therapeutic potential…
Zargham Faisal, Aimen Mazhar, Syeda Ayesha Batool, Noor Akram + 6 more
'Maleeha Hassan' 'Muhammad Usman Khan' 'Muhammad Afzaal' 'Usman Ul Hassan' 'Yasir Abbas Shah' 'Derese Tamiru Desta'] Title: Abstract Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health-promoting properties. It has been demonstrated, after reviewing various…
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu + 1 more
Ovarian cancer is a heterogeneous disease and is also the major cause of death among women from gynecologic malignancies. A combination of surgery and chemotherapy is the major therapy for ovarian cancer. Unfortunately, despite good response rates to initial surgery and chemotherapy, most patients relapse and have a…
Agnieszka Nowacka, Martyna Śniegocka, Wojciech Smuczyński, Sara Liss + 5 more
Resveratrol, a naturally occurring polyphenolic compound found in various plants, has been extensively studied for its broad spectrum of beneficial biological effects. These encompass its potent antioxidant properties, anti-inflammatory activities, anti-aging capabilities, cardioprotective functions, and…
Authors not listed
Trans-resveratrol, a naturally occurring antioxidant, undergoes significant photochemical transformations upon UV irradiation, producing photoisomers and derivatives such as cis-resveratrol, 2,4,6-trihydroxy-phenanthrene (THP), and resveratrone. Using quantum chemical methods, we investigated the photophysical…
Roxana Pop, Adela Daescu, Dumitrita Rugina, Adela Pintea + 1 more
'María P. Portillo'] Due to the confirmed therapeutic potential of resveratrol (Rv) for eye diseases, namely its powerful anti-angiogenic and antioxidant effects, this molecule must be studied more deeply. Nowadays, the pharmaceutic and pharmacokinetic available studies offer a troubling picture because of its low…
Ana Soriano-Lerma, Victoria Sánchez-Martín, Javier Murciano-Calles, Matilde Ortiz-González + 8 more
Resveratrol (RSV) is one of the most studied and used biomolecules, for which many pharmacological effects targeting multiple tissues have been described. However, a common underlying mechanism driving its full pharmacological activity has not been elucidated to date. G-quadruplexes (G4s) are non-canonical nucleic acid…
Juan Carlos Canedo-Santos, Iridian Mora-Martinez, Ingrid Karina Gutierrez-Garcia, Maria Guadalupe Ramirez-Romero + 1 more
Resveratrol consumption has linked with normalization of the risk factors of some diseases such as colon cancer and type 2 diabetes. The antioxidant phenotype caused by resveratrol has recognized as a key piece in the health benefits exerted by this phytochemical. Although the antioxidant activity showed by resveratrol…
Annabell Plauth, Anne Geikowski, Susanne Cichon, Silvia J. Wowro + 9 more
Resveratrol has gained tremendous interest owing to multiple reported health-beneficial effects. However, the underlying key mechanism of action of resveratrol remained largely controversial. Here, we demonstrate that under physiologically relevant conditions major biological effects of resveratrol can be attributed to…
Sophie Béraud-Dufour, Ilona Legroux, Thierry Coppola, Patricia Lebrun + 1 more
Stroke is a leading cause of disability and death worldwide, with ischemic strokes accounting for nearly 80% of cases. Fewer than 5% of patients receive the sole validated pharmacotherapy, intravenous thrombolysis, highlighting the urgent need for novel therapies. Within this landscape, the exploration of natural…
S. Kumar, P. Kumar, M. S. Nair
We report the interaction of resveratrol with an octamer DNA sequence d(CCAATTGG)_2_, present in the promoter region of many oncogenes, using a combination of absorption, fluorescence, calorimetric and nuclear magnetic resonance techniques to probe the binding. Resveratrol binds to the duplex sequence with a binding…
KG Woodman, CA Coles, SL Toulson, M Knight + 3 more
Duchenne muscular dystrophy (DMD) is a progressive and fatal neuromuscular disorder for which there is no treatment. Therapies to restore dystrophin deficiency are not ready for clinical use and long-term efficiency is yet to be established. Therefore, there is a need to develop alternative strategies to treat DMD.…
Ely G. F. de Miranda, Lucas M. Cornetta, Márcio T. do N. Varella
We report a computational study of the anion states of the resveratrol (RV) and resorcinol (RS) molecules, also investigating dissociative electron attachment (DEA) pathways. RV has well known beneficial effects in human health, and its antioxidant activity was previously associated with DEA reactions producing H2. Our…
Sridhar Mahadevan
Large language models can extract local causal claims from text, but those claims become more useful when organized as persistent, navigable world models rather than as flat summaries. We introduce PROMETHEUS, a framework that turns retrieved literature, filings, reviews, reports, agent traces, source data, code…
Bram M. ter Ellen, Nilima Dinesh Kumar, Ellen M. Bouma, Berit Troost + 10 more
The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy. In search for therapeutic options, researchers have proposed resveratrol, a food supplement with known antiviral, anti-inflammatory and anti-oxidant properties…
Jinzhu Jiang, Xianju Liu, Yi Wang, Zhenchang Liang + 1 more
Stilbenoids, a class of compounds with the stilbene skeleton as part of plant secondary metabolism, are renowned for their diverse health benefits. Among them, 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), specifically abundant in the famous medicinal plant Pleuropterus multiflorus, exhibits significant…
Authors not listed
Enzymatic decarboxylation of phenolic acids enables the production of biobased phenolic styrenes under mild reaction conditions. However, the free para-phenolic group can lead to undesirable side products during polymerization, giving protection of the free phenolic OH group critical importance for the application in…
tatsushi nakayama, bunji uno
The reactivity of 5-[(E)-2-(4-hydroxyphenyl)ethen-1-yl]benzene-1,3-diol (trans-resveratrol) and related compounds toward electrogenerated superoxide radical anion (O2•−) was investigated using electrochemistry, in situ electrolytic electron spin resonance, and in situ electrolytic ultraviolet–visible spectral…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Eric Mayor
In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), caloric restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult neurogenesis (NSPAN) are essential examples of these neurotrophic effects. The…
Tatsushi Nakayama, bunji uno
The reactivity of 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol (piceatannol) toward electrochemically generated superoxide radical anion (O2•−) was investigated using electrochemistry and in situ controlled-potential electrolytic electron spin resonance (ESR) measurements in N,N-dimethylformamide with density…
Wherry, Owen H.
Aging is the primary risk factor for nearly all forms of human death, yet pharmaceutical interventions hold the potential to prevent it. Combinations of drugs have been shown to increase the lifespan of model organisms more than individual drugs, and geroprotective histone deacetylase (HDAC) inhibitors that have…
Enrico Catalano
Phytochemicals are plant-derived secondary metabolites, which may exert many biological activities in humans, including anticancer properties. Although recent findings appear to support their role in cancer prevention and treatment, this issue is still controversial. Anti-cancer activity of phytochemicals mainly…