20 papers · ranked by Valyu relevance
Peter M.J. Quinn, Jan Wijnholds
The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling of cell density sensing to downstream cell signaling pathways, and in regulating junctional structures and cell adhesion. The Crumbs complex acts as a conductor orchestrating multiple downstream signaling pathways in…
Anne Vielle, Yuna K. Park, Conner Secora, M. Natalia Vergara
The cumulative knowledge of retina development has been instrumental in the generation of retinal organoid systems from pluripotent stem cells; and these three-dimensional organoid models, in turn, have provided unprecedented opportunities for retinal research and translational applications, including the ability to…
Bochen Liu, Yi Liu, Haiyan Zhang, Jing Huang + 1 more
Inherited retinal diseases (IRDs) constitute a complex and heterogeneous group of rare disorders characterized by significant genetic diversity. These conditions often lead to the degeneration of photoreceptor cells, resulting in severe visual impairment. A major challenge in the study and treatment of IRDs is the lack…
Kristen E. Ashworth, Jessica Weisbrod, Brian G. Ballios, Chloe M. Stanton
'Chloe M. Stanton'] Inherited retinal diseases (IRDs) are a large group of genetically and clinically diverse blinding eye conditions that result in progressive and irreversible photoreceptor degeneration and vision loss. To date, no cures have been found, although strides toward treatments for specific IRDs have been…
Ashley M. Rasys, Shana H. Pau, Katherine E. Irwin, Sherry Luo + 4 more
The fovea, a pit in the retina, is believed to be important for high-acuity vision and is a feature found in the eyes of humans and a limited number of vertebrate species that include certain primates, birds, lizards, and fish. At present, model systems currently used for ocular research lack a foveated retina and…
Cristina Garcia-Frigola, Maria Isabel Carreres, Celia Vegar, Eloisa Herrera
'Eloisa Herrera'] Background The neural retina is a highly structured tissue of the central nervous system that is formed by seven different cell types that are arranged in layers. Despite much effort, the genetic mechanisms that underlie retinal development are still poorly understood. In recent years, large-scale…
Alessandro Bellapianta, Ana Cetkovic, Matthias Bolz, Ahmad Salti + 1 more
'Settimio Rossi'] Despite the progress of modern medicine in the last decades, millions of people diagnosed with retinal dystrophies (RDs), such as retinitis pigmentosa, or age-related diseases, such as age-related macular degeneration, are suffering from severe visual impairment or even legal blindness. On the one…
Kiara C. Eldred, Sierra J. Edgerton, Isabel Ortuño-Lizarán, Juliette Wohlschlegel + 7 more
Non-mammalian vertebrates maintain a proliferative stem cell population at the far periphery of their retina called the ciliary marginal zone (CMZ), which gives rise to all retinal cell types and contributes to retinal regeneration upon injury. Humans do not maintain a proliferative CMZ into adulthood; however, it is…
Alexander Muacevic, John R Adler, Yash V Lath, Archana R Thool + 1 more
'Indrayani Jadhav'] Retinitis pigmentosa and age-related macular degeneration are the most frequent causes of irreversible visual impairment in the world. Existing therapeutic methods could be more effective, underscoring the necessity of new treatments. Reconstructing the retinal photoreceptors through the…
Erping Long, Xiayin Zhang, Zhenzhen Liu, Xiaohang Wu + 13 more
Sensitive periods and experience-dependent plasticity have become core issues in visual system development. Converging evidence indicates that visual experience is an indispensable factor in establishing mature visual system circuitry during sensitive periods and the visual system exhibits substantial plasticity when…
Tatiana V. Tkatchenko, Tatyana V. Michurina, Stanislav I. Tomarev, Naoki Nakaya + 2 more
It is generally accepted that retinal neurogenesis in mammals ceases shortly after birth and that stem/progenitor cells found in the postnatal eyes of mice and humans are in the quiescent state. In the present study, we have investigated postnatal retinal neurogenesis and its modulation by visual experience in the…
Sophie Creuzet, Heather Etchevers
Afin d'appréhender les mécanismes qui sous-tendent la physiologie de la vision, la connaissance des bases embryologiques du développement de l'œil et de ses annexes est un prérequis indispensable. La morphogénèse oculaire débute au cours de la quatrième semaine de vie embryonnaire, alors que l'ébauche oculaire…
Jennifer Crodelle, Wei P. Dai
Spontaneous waves are ubiquitous during early brain development and are hypothesized to drive the development of receptive fields (RFs). Different stages of spontaneous waves in the retina have been observed to coincide with the development of the retinotopic map, ON-OFF segregation, and orientation selectivity in the…
Katja A. Salbaum, Elijah Shelton, Friedhelm Serwane
With a kind of magnetism, the human retina draws the eye of neuroscientist and physicist alike. It is attractive as a self-organizing system, which forms as a part of the central nervous system via biochemical and mechanical cues. The retina is also intriguing as an electro-optical device, converting photons into…
Mathieu Quinodoz, Elifnaz Celik, Dhryata Kamdar, Francesca Cancellieri + 27 more
Inherited retinal diseases (IRDs) are rare disorders, typically presenting as Mendelian traits, that result in stationary or progressive visual impairment. They are characterized by extensive genetic heterogeneity, possibly the highest among all human genetic diseases, as well as diverse inheritance patterns. Despite…
William Ebo Annan, Emmanuel O.A. Asamani, Diana White
Retinal detachment (RD) is the separation of the neural layer from the retinal pigmented epithelium thereby preventing the supply of nutrients to the cells within the neural layer of the retina. In vertebrates, primary photoreceptor cells consisting of rods and cones undergo daily renewal of their outer segment through…
Devrım Toslak, Felix Y. Chau, Muhammet Kazım Erol, Changgeng Liu + 3 more
'R.V. Paul Chan' 'Taeyoon Son' 'Xincheng Yao'] Abstract: This study is to test the feasibility of using trans-pars-planar illumination for ultrawide field pediatric fundus photography. Fundus examination of the peripheral retina is essential for clinical management of pediatric eye diseases. However, current pediatric…
Rickie Xian
Retinitis pigmentosa (RP), one of the leading causes of vision loss and blindness globally, is a progressive retinal disease involving the degradation of photoreceptors (7) and/or retinal pigment epithelial cells (14). Affecting approximately 1 in 4000 people, RP is caused by a series of genetic mutations, each…
Konstantin Komarov, Woojin Park, Seunghoon Lee, Miquel Huix-Rotllant + 1 more
It is demonstrated that significant accuracy improvements of MRSF-TDDFT can be achieved by introducing two different XC functionals for the reference Kohn-Sham DFT and the response part of calculations, respectively. Accordingly, two new exchange-correlation (XC) functionals of DTCAM-VEE and DTCAM-AEE were developed on…
Francesco Talotta, David Lauvergnat, Federica Agostini
The exact factorization of the electron-nuclear wavefunction is applied to the study of the photo- isomerization of a retinal chromophore model. We describe such an ultrafast nonadiabatic process by analyzing the time-dependent potentials of the theory and by mimicking nuclear dynamics with quantum and coupled…