22 papers · ranked by Valyu relevance
Xue Du, Anna G. Butler, Holly Y. Chen
The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of clinically and genetically heterogenous disorders that lead to progressive vision impairment or blindness. Although each disorder is rare, IRD accumulatively cause blindness in up to 5.5 million…
Xinyi He, Júlio César da Costa Moura, Pedro Gil Fernández, Paul Gläser + 4 more
Significant progress has been made in studying the individual steps of retinal signaling, yet a comprehensive understanding of the functional interplay between photoreceptors, as input cells, and retinal ganglion cells (RGCs), as output cells, remains elusive. This connection is crucial to fully unravel the retina’s…
Bruna Caridi, Dilyana Doncheva, Sobha Sivaprasad, Patric Turowski
Diseases of the retina are major causes of visual impairment and blindness in developed countries and, due to an ageing population, their prevalence is continually rising. The lack of effective therapies and the limitations of those currently in use highlight the importance of continued research into the pathogenesis…
Mathieu Quinodoz, Elifnaz Celik, Dhryata Kamdar, Francesca Cancellieri + 27 more
Inherited retinal diseases (IRDs) are rare disorders, typically presenting as Mendelian traits, that result in stationary or progressive visual impairment. They are characterized by extensive genetic heterogeneity, possibly the highest among all human genetic diseases, as well as diverse inheritance patterns. Despite…
Markus Meister
The scientific study of the retina has reached a remarkable state of completion. We can now explain many aspects of early visual processing based on a relatively simple model of neural circuitry in the retina. The same model, with different parameters, produces a great diversity of neural computations. In this article…
Ang Wei, Urmi V. Mehta, Grazyna Palczewska, Anton M. Palma + 7 more
Humans perceive light in the visible portion of electromagnetic radiation. However, visible light is scattered and attenuated by optical media opacities. Because all conventional visual function tests rely on visible light, test results are reduced in patients with optical media opacities like corneal scars, cataracts…
Vimal Prabhu Pandiyan, Xiaoyun Jiang, Aiden Maloney Bertelli, James A. Kuchenbecker + 2 more
Optoretinography – the non-invasive, optical imaging of light-induced functional activity in the retina – stands to provide a critical biomarker for testing the safety and efficacy of new therapies as well as their rapid translation to the clinic. Optical phase change in response to light, as readily accessible in…
Michal Fila, Jan Krekora, Jarosław Drożdż, Kai Kaarniranta + 1 more
Objective This narrative review aims to examine potential associations between migraine and retinal disorders, with particular attention to retinal migraine, age-related macular degeneration (AMD), retinal vascular occlusions, and photophobia. Background The role of retinal pathways in migraine pathophysiology remains…
Gaia Ziraldo, Sara Cupini, Valentina Sesti, Emanuela Delfino + 4 more
The lack of effective therapies for visual restoration in Retinitis pigmentosa and macular degeneration has led to the development of new strategies such as optogenetics and retinal prostheses. However, visual restoration is poor due to the massive light-evoked activation of retinal neurons, regardless of the…
William Ebo Annan, Emmanuel O.A. Asamani, Diana White
Retinal detachment (RD) is the separation of the neural layer from the retinal pigmented epithelium thereby preventing the supply of nutrients to the cells within the neural layer of the retina. In vertebrates, primary photoreceptor cells consisting of rods and cones undergo daily renewal of their outer segment through…
Νικόλας Παπαδόπουλος, Nikos Melanitis, Antonio Lozano, Cristina Soto-Sánchez + 2 more
'Cristina Soto-Sánchez' 'Eduardo Fernández' 'Konstantina S. Nikita'] © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new…
Ungsoo Samuel Kim, Omar A. Mahroo, John D. Mollon, Patrick Yu-Wai-Man
'Patrick Yu-Wai-Man'] Retinal ganglion cells (RGCs) are the bridging neurons that connect the retinal input to the visual processing centres within the central nervous system. There is a remarkable diversity of RGCs and the various subtypes have unique morphological features, distinct functions, and characteristic…
Steven F. Stasheff
Hereditary retinal degenerations result from varied pathophysiologic mechanisms, all ultimately characterized by photoreceptor dysfunction and death. Hence, much research on these diseases has concentrated on the outer retina. Over the past decade or so increasing attention has focused on concomitant changes in complex…
Samuel Chiquita
Neural circuits in the retina divide the incoming visual scene into more than a dozen distinct representations that are sent on to central brain areas, such as the lateral geniculate nucleus and the superior colliculus. The retina can be viewed as a parallel image processor made of a multitude of small computational…
Moussa A. Zouache
Aging is associated with a broad range of visual impairments that can have dramatic consequences on the quality of life of those impacted. These changes are driven by a complex series of alterations affecting interactions between multiple cellular and extracellular elements. The resilience of many of these interactions…
Shounak Datta, Eduardo B. Mariottoni, David Dov, Alessandro A. Jammal + 2 more
'Alessandro A. Jammal' 'Lawrence Carin' 'Felipe A. Medeiros'] Glaucoma is the leading cause of irreversible blindness in the world, affecting over 70 million people. The cumbersome Standard Automated Perimetry (SAP) test is most frequently used to detect visual loss due to glaucoma. Due to the SAP test's innate…
Anthony G. Robson, Josefin Nilsson, Shiying Li, Subhadra Jalali + 4 more
'Anne B. Fulton' 'Alma Patrizia Tormene' 'Graham E. Holder' 'Scott E. Brodie'] Clinical electrophysiological testing of the visual system incorporates a range of noninvasive tests and provides an objective indication of function relating to different locations and cell types within the visual system. This document…
Rickie Xian
Retinitis pigmentosa (RP), one of the leading causes of vision loss and blindness globally, is a progressive retinal disease involving the degradation of photoreceptors (7) and/or retinal pigment epithelial cells (14). Affecting approximately 1 in 4000 people, RP is caused by a series of genetic mutations, each…
Konstantin Komarov, Woojin Park, Seunghoon Lee, Miquel Huix-Rotllant + 1 more
It is demonstrated that significant accuracy improvements of MRSF-TDDFT can be achieved by introducing two different XC functionals for the reference Kohn-Sham DFT and the response part of calculations, respectively. Accordingly, two new exchange-correlation (XC) functionals of DTCAM-VEE and DTCAM-AEE were developed on…
Francesco Talotta, David Lauvergnat, Federica Agostini
The exact factorization of the electron-nuclear wavefunction is applied to the study of the photo- isomerization of a retinal chromophore model. We describe such an ultrafast nonadiabatic process by analyzing the time-dependent potentials of the theory and by mimicking nuclear dynamics with quantum and coupled…
N. Krishna Santosh, Soubhagya Sankar Barpanda
In this paper, we have proposed a new glaucoma classification approach that employs a wavelet neural network (WNN) on optimally enhanced retinal images' features. To avoid tedious and error-prone manual analysis of retinal images by ophthalmologists, computer-aided diagnosis (CAD) substantially aids in robust…
Authors not listed
Channelrhodopsin-2 (ChR2) is a light-gated ion channel widely used in optogenetics, a technique that enables precise control of neuronal activity by genetically engineering light-sensitive proteins into cell membranes. This protein exists in dimeric form, with each monomer containing a retinal Schiff base (RSB) moiety…