24 papers · ranked by Valyu relevance
Artur V. Cideciyan, Samuel G. Jacobson, Alejandro J. Roman, Alexander Sumaroka + 6 more
'Alexander Sumaroka' 'Vivian Wu' 'Jason Charng' 'Brianna Lisi' 'Malgorzata Swider' 'Gustavo D. Aguirre' 'William A. Beltran'] A common inherited retinal disease is caused by mutations in RHO expressed in rod photoreceptors that provide vision in dim ambient light. Approximately half of all RHO mutations result in a…
Koji M. Nishiguchi, Kosuke Fujita, Enrico Cristante, James W. Bainbridge + 4 more
Cone photoreceptors mediate daylight vision and are the primary cells responsible for vision in humans. Cone dysfunction leads to poor quality daylight vision because rod photoreceptors become saturated and non-functional at high light levels. Here we demonstrate that in mice lacking cone function, AAV-mediated…
Mary Anne Garner, Meredith G. Hubbard, Evan R. Boitet, Seth T. Hubbard + 5 more
NUDC (nuclear distribution protein C) is a mitotic protein involved in nuclear migration and cytokinesis across species. Considered a cytoplasmic dynein (henceforth dynein) cofactor, NUDC was shown to associate with the dynein motor complex during neuronal migration. NUDC is also expressed in postmitotic vertebrate rod…
Patricia D. A. Rohs, Jackson Buss, Sue Sim, Georgia Squyres + 9 more
Cell elongation in rod-shaped bacteria is mediated by the Rod system, a conserved morphogenic complex that spatially controls cell wall (CW) assembly. In Escherichia coli, alterations in a CW synthase component of the system called PBP2 were identified that overcome other inactivating defects. Rod system activity was…
Randy M. Morgenstein, Benjamin P. Bratton, Joshua W. Shaevitz, Zemer Gitai
Cell shape in bacteria is determined by the cell wall, which is synthesized by a variety of proteins whose actions are coordinated by the actin-like MreB protein. MreB uses local geometric cues of envelope curvature to avoid the cell poles and localize to specific regions of the cell body. However, it remains unclear…
Xufeng Dai, Hua Zhang, Ying He, Yan Qi + 3 more
'Stephan C.F. Neuhauss'] Early studies on Rpe65 knockout mice reported that remaining visual function was attributable to cone function. However, this finding has been challenged more and more as time has passed. Electroretinograms (ERGs) showed that rd12 mice, a spontaneous animal model of RPE65 Leber’s congenital…
Federica Genovese, Johannes Reisert, Vladimir J. Kefalov
The past decades have seen tremendous progress in our understanding of the function of photoreceptors and olfactory sensory neurons, uncovering the mechanisms that determine their properties and, ultimately, our ability to see and smell. This progress has been driven to a large degree by the powerful combination of…
Meet K. Patel, Warlen Piedade, Jakub K. Famulski
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be associated with the incidence of cone-rod dystrophy and recapitulated in mouse…
János Lelkes, Bendegúz Dezső Bak, Tamás Kalmár-Nagy
Functionally graded materials have broad engineering applications including mechanical engineering, electronics, chemistry, and biomedical engineering. One notable advantage of such materials is that their stiffness distribution can be optimized to avoid stress concentration. A novel approach for solving the equations…
Simon R. Eugster, Jonas Harsch
The standard in rod finite element formulations is the Bubnov–Galerkin projection method, where the test functions arise from a consistent variation of the ansatz functions. This approach becomes increasingly complex when highly nonlinear ansatz functions are chosen to approximate the rod's centerline and cross-section…
Carlo Alessi, Camilla Agabiti, Daniele Caradonna, Cecilia Laschi + 2 more
'Federico Renda' 'Egidio Falotico'] Continuum and soft robots can positively impact diverse sectors, from biomedical applications to marine and space exploration, thanks to their potential to adaptively interact with unstructured environments. However, the complex mechanics exhibited by these robots pose diverse…
Ignacio Romero, Cristian Guillermo Gebhardt
The present article studies variational principles for the formulation of static and dynamic problems involving Kirchhoff rods in a fully nonlinear setting. These results, some of them new, others scattered in the literature, are presented in a systematic way, helping to clarify certain aspects that have remained…
Suman Maharjan, Ryan Sloan, Jada Lusk, Rose Bevienguevarr + 2 more
The bacterial actin-homolog MreB is a crucial component of the rod-system (elongasome) that maintains rod shape in many bacteria. It is localized beneath the inner membrane where it organizes the elongasome complex. Depletion or deletion of mreB results in loss of rod shape and cell death; however, the mechanism of how…
Linjing Li, Kollu N. Rao, Hemant Khanna
X-linked retinitis pigmentosa 2 (XLRP2) patients and Rp2null mice exhibit severe cone photoreceptor degeneration. However, due to the paucity of cones in mammalian model systems, it is not clear how cones respond to the loss of RP2. Here we have used the Nrl-/- mice, which develop a rodless and short wavelength (S)…
Oxana Shamilyan, Ievgen Kabin, Zoya Dyka, Oleksandr Sudakov + 3 more
Many technical solutions are bio-inspired. Octopus-inspired robotic arms belong to continuum robots which are used in minimally invasive surgery or for technical system restoration in areas difficult-toaccess. Continuum robot missions are bounded with their motions, whereby the motion of the robots is controlled by…
Tongjia Zheng, Qing Han, Hai Lin
— State estimation of robotic systems is essential to implementing feedback controllers which usually provide better robustness to modeling uncertainties than open-loop controllers. However, state estimation of soft robots is very challenging because soft robots have theoretically infinite degrees of freedom while…
Ashley A. Rowe, Mauricio J. Velasquez, Jacob W. Aumeier, Sofia Reyes + 4 more
'Tiffany Yee' 'Emily R. Nettesheim' 'Jeffrey G. McDonald' 'Katherine J. Wert'] Neurodegenerative disorders such as Alzheimer’s disease and macular degeneration represent major sources of human suffering, yet factors influencing disease severity remain poorly understood. Sex has been implicated as one modifying factor.…
Giulio G. Giusteri, Eliot Fried
We discuss how the shape of a special Cosserat rod can be represented as a path in the special Euclidean algebra. By shape we mean all those geometric features that are invariant under isometries of the three-dimensional ambient space. The representation of the shape as a path in the special Euclidean algebra is…
Meet K. Patel, Warlen Piedade, Jakub K. Famulski
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be associated with the incidence of cone-rod dystrophy and recapitulated in mouse…
Meet K. Patel, Warlen Piedade, Jakub K. Famulski
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be associated with the incidence of cone-rod dystrophy and recapitulated in mouse…
Authors not listed
We present a coupled-oscillator toy model that describes the low-frequency lattice-like vibrations observed in Raman and inelastic neutron scattering spectra of β-sheet structures found in amyloid fibrils. In this model, the strands of the fibril β-sheet structures are treated as harmonically oscillating rods with…
Authors not listed
Fluorescent dye-loaded polymeric nanoparticles have been extensively developed for cellular imaging as they are bright and versatile tools with large choice of polymers, dyes and surface chemistry. Here, we report preparation of fluorescent polymeric nanomaterials with high aspect ratio – nanorods, and study their…
James Hooper, Darshita Budhadev, Dario Fernandez Ainaga Ainaga, Nicole Hondow + 2 more
Multivalent lectin-glycan interactions (MLGIs) are widespread and vital for biology, and also hold the key to many therapeutic applications. However, the underlying structural and biophysical mechanisms for many MLGIs remain poorly understood, limiting our ability to design glycoconjugates that can potently target…
Amelia Carolina Sparavigna
Previous studies (Sparavigna, 2023) have demonstrated the Tsallis q-Gaussian functions suitable for the analysis of Raman spectra. Here we consider two asymmetric forms of them, with the aim of further improving the fitting of Raman spectra. The first asymmetric form, that we are here proposing for the first time, is a…