20 papers · ranked by Valyu relevance
Rui Zhan, Han Gong, Ying Li, Yuanyuan Cui + 3 more
Most bacteria are surrounded by a peptidoglycan (PG) matrix that maintains cell shape and provides protection against turgor pressure. In many rod-shaped bacteria, synthesis of PG along the cell cylinder is organized by the elongasome, also called the Rod complex, which consists of six highly conserved proteins…
Feifei Wang, Alexander V. Kolesnikov, Shinya Sato, Aneal Singh + 3 more
The function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral composition and overall intensity. One notable example is the…
Nazarul Hasan, Mattia D. Paolo, Maureen A. McCall, Ronald G. Gregg
Vision depends on the transfer of photoreceptor signals through the retina and then to many CNS visual nuclei. While the most common inherited retinal diseases (IRDs) involve defects in rod and/or cone function, another group (referred to as congenital stationary night blindness (CSNB)) results from defects in…
Fei Gao, Yuqiang Zheng, Tianyi Wang, Mingqi Zhang + 4 more
Retinal degeneration (RD) is an intractable ophthalmic disorder with no effective treatments, and its pathogenesis is complex, involving multiple genes. Endoplasmic reticulum (ER) stress and neuronal apoptosis are key factors that drive neurodegeneration in retinal degeneration. B cell receptor-associated protein 31…
Feifei Wang, Alexander V. Kolesnikov, Shinya Sato, Aneal Singh + 3 more
The function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral composition and overall intensity. One notable example is the…
Khanh Chau Le
This study utilizes the variational-asymptotic method to establish a onedimensional theory for functionally graded rods characterized by general anisotropy from the three-dimensional elasticity theory. A distinctive feature of this dimension reduction procedure is the numerical solution of dual crosssectional problems…
Chi Sun, Charles W. Pfeifer, Yiqiao Zheng, Rajendra S. Apte + 1 more
CRX is a transcription factor essential for photoreceptor differentiation and functional development. Two missense mutations in CRX homeodomain, CRX^E80A^ and CRX^K88N^, are linked to early-onset dominant retinopathies. Molecular studies have revealed distinct profiles of perturbed gene expression in differentiating…
Suman Maharjan, Ryan Sloan, Jada Lusk, Rose Bevienguevarr + 3 more
The bacterial actin-homolog MreB is a crucial component of the Rod-system (elongasome) that maintains rod shape in many bacteria. It is localized beneath the cytoplasmic membrane, where it organizes the elongasome complex. Depletion or deletion of mreB results in loss of rod shape and cell death; however, the mechanism…
Fu-Sheng Tang, Miao-Miao Kong, Ya-Ru Luo, Zi-Xuan Wang + 12 more
How conserved neural circuits are modified during mammalian evolution remains poorly understood. Here we combine cross-species single-cell transcriptomics, in situ validation, retinal physiology, and conditional genetics to identify a superorder-associated adrenergic module in the mammalian retina. We find that ADRB1…
Trong Thuan Ung, Gillian N. Huskin, Sanford Boye, Yuchen Wang
Synaptic dysfunction and neurite remodeling are early features of many inherited retinal diseases, but whether synaptic function can be restored after circuit remodeling remains unclear. We evaluated the therapeutic potential of adeno-associated virus (AAV)-mediated α2δ4 gene supplementation in a mouse model of…
James M. Ferguson, Mengyu Fu, Fábio Ramos
— Previous on-manifold approaches to continuum robot state estimation have typically adopted simplified Cosserat rod models, which cannot directly account for actuation inputs or external loads. We introduce a general framework that incorporates uncertainty models for actuation (e.g., tendon tensions), applied forces…
Navid Feizi, Filipe C. Pedrosa, Rajni V. Patel, Jagadeesan Jayender
Modeling concentric tube robots (CTRs) involves complex nonlinear continuum mechanics, and despite recent progress, physics-based models often lack an accurate representation of the experimental setups. To overcome these limitations, deep neural network-based models have been explored as alternatives with superior…
Nazarul Hasan, Ronald G. Gregg
LRIT3 is a leucine-rich repeat (LRR) protein that is expressed in the retina, and its absence causes complete congenital stationary night blindness (cCSNB), a genetically diverse disorder characterized by impaired low-light vision, myopia, and nystagmus. LRIT3 is expressed in rod and cone photoreceptors, and it…
Chi Sun, Michael Fitzpatrick, Daniel Kerschensteiner, Shiming Chen
Cone-rod dystrophies (CoRD) are inherited retinal diseases (IRDs) with variable ages of onset, characterized by the progressive loss of cones, followed by secondary degeneration of rods. Cone-rod homeobox (CRX) is a transcription factor that regulates gene expression essential for photoreceptor development and…
Yan, Mingjia, M. Warda, Balázs Németh + 2 more
Slender structures are ubiquitous in biological and physical systems, from bacterial flagella to soft robotic arms. The Cosserat rod provides a mathematical framework for slender bodies that can stretch, shear, twist and bend. In viscous fluid environments at low Reynolds numbers—as encountered in soft matter physics…
Adree Songco Aguas, Fred Rieke, Gabrielle J. Gutierrez
Under mesopic conditions, such as dawn or dusk, signals from both rod and cone photoreceptors contribute to perception. These parallel inputs are combined within the retina before being sent to subsequent visual areas. The integration of these kinetically-distinct parallel signals poses unique challenges for human…
Thomas Lessinnes
The equilibrium equations of elastic rods can be obtained by balancing forces and moments, or by rendering a potential energy stationary. For complex filaments the energy route asks less of one's mechanical intuition. However, in the classical Hamiltonian picture, the components of the generalized momenta are…
Meet K. Patel, Warlen Piedade, Jakub K. Famulski
Cone rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell photoreceptor degeneration and subsequently of rod photoreceptors. Mutations in CDHR1, a photoreceptor specific cadherin have been found to be associated with the incidence of cone-rod dystrophy and recapitulated in mouse…
Chris Quiñones, Peter D. Olmsted
In this work we develop constitutive equations for a dense, sheared suspension of frictionally interacting rods by applying Onsager's variational method as formulated by Doi. We treat both solid friction, of the Amontons-Coulomb form; and lubricated friction, which scales with relative tangential velocity at the…
Athira Ramesh, Suganya Sivagurunathan, Navya Valavath Baburajan, Subbulakshmi Chidambaram
The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood…