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20 papers · ranked by Valyu relevance

01
PPubMed9 Sep 2025
A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection
Bhawna, Swapnava Basu, Syed Yusuf Mian, Sanchi Arora + 6 more
Viruses transit from a low to high multiplicity of infection (MOI) regime in infected tissues. Type-1 interferons (IFNs) enforce a cellular state refractory to virus multiplication, while the death of infected cells eliminates viral replicative niche. Here, we investigated how these two innate antiviral mechanisms…
77relevance
02
PPubMed1 May 2026
A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection
Bhawna, Swapnava Basu, Syed Yusuf Mian, Sanchi Arora + 7 more
Viruses transit from a low to high multiplicity of infection (MOI) regime in infected tissues. Type-1 interferons (IFNs) enforce a cellular state refractory to virus multiplication, while the death of infected cells eliminates viral replicative niche. Here, we investigated how these two innate antiviral mechanisms…
76relevance
03
BbioRxiv9 Sep 2025
A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection
Bhawna, Swapnava Basu, Syed Yusuf Mian, Sanchi Arora + 6 more
Viruses transit from a low to high multiplicity of infection (MOI) regime in infected tissues. Type-1 interferons (IFNs) enforce a cellular state refractory to virus multiplication, while the death of infected cells eliminates viral replicative niche. Here, we investigated how these two innate antiviral mechanisms…
71relevance
04
AarXiv2015
Backward bifurcation underlies rich dynamics in simple disease models
Wenjing Zhang, Pei Yu, Lindi M. Wahl
In this paper, dynamical systems theory and bifurcation theory are applied to investigate the rich dynamical behaviours observed in three simple disease models. The 2- and 3-dimensional models we investigate have arisen in previous investigations of epidemiology, in-host disease, and autoimmunity. These closely related…
70relevance
05
AarXiv2014
Stability and Hopf Bifurcation in a delayed viral infection model with mitosis transmission
Eric Ávila-Vales, Noé Chan-Chí, Gerardo García-Almeida, Cruz Vargas‐De‐León
'Cruz Vargas‐De‐León'] In this paper we study a model of HCV with mitotic proliferation, a saturation infection rate and a discrete intracellular delay: the delay corresponds to the time between infection of a infected target hepatocytes and production of new HCV particles. We establish the global stability of the…
64relevance
06
BbioRxiv3 Feb 2019
Quantifying bacterial fitness in intracellular dynamics^*^
Francisco F. S. Paupério, Erida Gjini
Understanding bacterial infection is challenging because it involves a complex interplay of host, pathogen, and intervention factors. To design successful control measures, mathematical models that quantify such interplay at the level of populations and phenotypes are needed. Here, we study a key aspect of…
63relevance
07
PPubMed14 Feb 2019
Sepsis: mechanisms of bacterial injury to the patient
Hayk Minasyan
In bacteremia the majority of bacterial species are killed by oxidation on the surface of erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing bacteria overcome this mechanism of human innate immunity by versatile respiration, production of antioxidant enzymes, hemolysins, exo- and…
59relevance
08
BbioRxiv23 Nov 2018
Biofilm/Persister/Stationary Phase Bacteria Cause More Severe Disease Than Log Phase Bacteria – II Infection with Persister Forms of *Staphylococcus aureus* Causes a Chronic Persistent Skin Infection with More Severe Lesion that Takes Longer to Heal and is not Eradicated by the Current Recommended Treatment in Mice
Rebecca Yee, Yuting Yuan, Cory Brayton, Andreina Tarff Leal + 4 more
Staphylococcus aureus is an opportunistic pathogen that can cause persistent infections clinically. Treatment for chronic S. aureus infections ranges from at least one week to several months and such infections are prone to relapse likely due to the presence of persistent forms of bacteria such as persister cells.…
58relevance
09
PPubMed23 Jun 2023
Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature
Shanisa Naidoo, Arnold M. Zwane, Ahmed Paruk, Timothy Craig Hardcastle + 1 more
'Timothy Craig Hardcastle' 'Evangelos Terpos'] Background: Skin and soft tissue infections (SSTIs) are common presentations in the emergency department. However, this is less common after contact with contaminated saltwater or freshwater. This review presents the diagnosis and management of water-related soft tissue…
58relevance
10
BbioRxiv5 Nov 2024
Chronic mycobacteria infection triggers macrophage senescence
E. Scarpa, D. Oliveri, G. Moschetti, A. Griego + 11 more
Chronic infections with intracellular pathogens such as Mycobacterium abscessus (Mab) pose significant health challenges due to their capacity to persist within host cells and evade immune responses. This study investigates the cellular responses to chronic Mab infection in macrophages, particularly focusing on…
56relevance
11
AarXiv29 Jan 2022
Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination
Wenjing Zhang
Mycobacterium tuberculosis infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and multidrug-resistant strains. To overcome the constraints of pathogen-directed therapy…
54relevance
12
AarXiv3 May 2018
Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds
Paul Roberts, Ryan M. Huebinger, Emma Keen, Anne Marie Krachler + 1 more
'Sara Jabbari'] As the development of new classes of antibiotics slows, bacterial resistance to existing antibiotics is becoming an increasing problem. A potential solution is to develop treatment strategies with an alternative mode of action. We consider one such strategy: anti-adhesion therapy. Whereas antibiotics…
53relevance
13
CchemRxiv27 Feb 2023
Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein
Aakansha Nangarlia, Farah Fazloon Hassen, Gabriela Canziani, Praneeta Bandi + 10 more
Host cell infection by SARS-CoV-2, similar to that by HIV-1, is driven by a conformationally metastable and highly glycosylated surface entry protein complex, and infection by these viruses has been shown to be inhibited by the mannose-specific lectins Cyanovirin-N (CV-N) and Griffithsin (GRFT). We discovered in this…
53relevance
14
CchemRxiv3 Sep 2021
COVID-19: Invades Erythrocytes through Plasmodium Falciparum Antigen and Complement-Like System
wenzhong liu, hualan li
Malaria symptoms are very similar to those of COVID-19, and infections can be symptomatic or asymptomatic. Common immunodominant epitopes are shared by the SARS-CoV-2 proteins and the Plasmodium falciparum antigen. Through bioinformatics methods such as domain search, this study discovered that the S, ORF3a proteins…
53relevance
15
AarXiv2017
Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host
Hasan Ahmed, Mia Moore, Balaji Manicassamy, Adolfo García‐Sastre + 2 more
'Andreas Handel' 'Rustom Antia'] How important is resource depletion (e.g. depletion of target cells) in controlling infection within a host? And how can we distinguish between resource depletion and other mechanisms that may contribute to decline of pathogen load or lead to pathogen clearance? In this paper we examine…
53relevance
16
AarXiv13 Apr 2020
A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract
Christian Quirouette, Nada P. Younis, Micaela B. Reddy, Catherine A. A. Beauchemin
'Catherine A. A. Beauchemin'] Within the human respiratory tract (HRT), viruses diffuse through the periciliary fluid (PCF) bathing the epithelium, and travel upwards via advection towards the nose and mouth, as the mucus escalator entrains the PCF. While many mathematical models (MMs) to date have described the course…
53relevance
17
BbioRxiv10 Jan 2024
Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive *Escherichia coli* infection
Xiang Li, John Cole, Diane Vaughan, Yinbo Xiao + 2 more
Bacterial infection is a dynamic process resulting in a heterogenous population of infected and uninfected cells. These cells respond differently based on their bacterial load and duration of infection. In the case of infection of macrophages with Crohn’s disease (CD) associated adherent-invasive Escherichia coli…
53relevance
18
AarXiv18 Jan 2024
Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity
Amey Nitin Agharkar, Dipasree Hajra, Durbar Roy, Vivek Jaiswal + 3 more
'Prasenjit Kabi' 'Dipshikha Chakravortty' 'Saptarshi Basu'] The transmission of viruses/ bacteria cause infection predominantly via aerosols. The transmission mechanism of respiratory diseases is complex, including direct or indirect contact, large droplet, and airborne routes apart from close contact transmission.…
52relevance
19
PPubMed16 Oct 2017
An Outbreak of Pseudomonas Aeruginosa Infection Linked to a “Black Friday” Piercing Event
Peter MacPherson, Katherine Valentine, Victoria Chadderton, Evdokia Dardamissis + 7 more
'Evdokia Dardamissis' 'Ian Doig' 'Andrew Fox' 'Sam Ghebrehewet' 'Tom Hampton' 'Ken Mutton' 'Claire Sherratt' 'Catherine M. McCann'] Introduction Outbreaks linked to cosmetic piercing are rare, but can cause significant illness. We report the investigation and management of a point-source outbreak that occurred during a…
51relevance
20
CchemRxiv13 Jan 2026
Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
Authors not listed
Methicillin-resistant Staphylococcus aureus (MRSA) is one of a leading cause of antibiotic-resistant bacterial infections. Based on our previous findings, we utilized thiazole-fused nootkatone hit compounds to develop a simple phenol-substituted thiazole scaffold as potent antibacterial agents, particularly active…
50relevance

Results for saturating infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

Backward bifurcation underlies rich dynamics in simple disease models

Stability and Hopf Bifurcation in a delayed viral infection model with mitosis transmission

Quantifying bacterial fitness in intracellular dynamics^*^

Sepsis: mechanisms of bacterial injury to the patient

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Chronic mycobacteria infection triggers macrophage senescence

Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination

Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

COVID-19: Invades Erythrocytes through Plasmodium Falciparum Antigen and Complement-Like System

Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

An Outbreak of Pseudomonas Aeruginosa Infection Linked to a “Black Friday” Piercing Event

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

Backward bifurcation underlies rich dynamics in simple disease models

Stability and Hopf Bifurcation in a delayed viral infection model with mitosis transmission

Quantifying bacterial fitness in intracellular dynamics^*^

Sepsis: mechanisms of bacterial injury to the patient

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Chronic mycobacteria infection triggers macrophage senescence

Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination

Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

COVID-19: Invades Erythrocytes through Plasmodium Falciparum Antigen and Complement-Like System

Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

An Outbreak of Pseudomonas Aeruginosa Infection Linked to a “Black Friday” Piercing Event

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection

Results for saturating infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

Backward bifurcation underlies rich dynamics in simple disease models

Stability and Hopf Bifurcation in a delayed viral infection model with mitosis transmission

Quantifying bacterial fitness in intracellular dynamics^*^

Sepsis: mechanisms of bacterial injury to the patient

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Chronic mycobacteria infection triggers macrophage senescence

Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination

Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

COVID-19: Invades Erythrocytes through Plasmodium Falciparum Antigen and Complement-Like System

Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive *Escherichia coli* infection

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

An Outbreak of Pseudomonas Aeruginosa Infection Linked to a “Black Friday” Piercing Event

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection

Backward bifurcation underlies rich dynamics in simple disease models

Stability and Hopf Bifurcation in a delayed viral infection model with mitosis transmission

Quantifying bacterial fitness in intracellular dynamics^*^

Sepsis: mechanisms of bacterial injury to the patient

Diagnosis and Management of Severe Water-Related Skin and Soft Tissue Sepsis: A Summative Review of the Literature

Chronic mycobacteria infection triggers macrophage senescence

Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination

Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds

Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein

COVID-19: Invades Erythrocytes through Plasmodium Falciparum Antigen and Complement-Like System

Mathematical analysis of a mouse experiment suggests little role for resource depletion in controlling influenza infection within host

A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive *Escherichia coli* infection

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

An Outbreak of Pseudomonas Aeruginosa Infection Linked to a “Black Friday” Piercing Event

Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection