26 papers · ranked by Valyu relevance
Shaked Tayouri, Vladislav Kogan, Jacob Beal, Tal Levy + 7 more
Biosecurity screening of synthetic DNA orders is a key defense against malicious actors and careless enthusiasts producing dangerous pathogens or toxins. It is important to evaluate biosecurity screening tools for potential vulnerabilities and to work responsibly with providers to ensure that vulnerabilities can be…
Anne Andermann
Background Screening for the social determinants of health in clinical practice is still widely debated. Methods A scoping review was used to (1) explore the various screening tools that are available to identify social risk, (2) examine the impact that screening for social determinants has on health and social…
Amanda Scudder, Richard Rosin, Becky Baltich Nelson, Edwin D. Boudreaux + 1 more
Background According to the Centers for Disease Control and Prevention, suicidality and suicidal behavior among youth continues to increase significantly each year. Many of those who die by suicide interact with health services in the year before death. This systematic review sought to identify and describe empirically…
Aderibigbe Oluwakemi Olanike, Christopher M Perlman
The needs of people diagnosed with Mental Neurological and Substance-Use (MNS) conditions are complex including interactions physical, social, medical and environmental factors. Treatment requires a multidisciplinary approach including health and social services at different levels of care. However, due to inadequate…
Xinyu Mao, Teerapong Leelanupab, Harrisen Scells, Guido Zuccon
based on Dense Retrieval Authors: ['Xinyu Mao' 'Teerapong Leelanupab' 'Harrisen Scells' 'Guido Zuccon'] Abstract. Screening is a time-consuming and labour-intensive yet required task for medical systematic reviews, as tens of thousands of studies often need to be screened. Prioritising relevant studies to be screened…
Althea Hansel-Harris, Andreas Tillack, Diogo Santos-Martins, Matthew Holcomb + 1 more
Virtual screening using molecular docking is now routinely used for the rapid evaluation of very large ligand libraries. As such, it has become an increasingly common approach in early-stage drug discovery. These screenings generate large amounts of data proportional to the size of the compound library used, which must…
Marta Truchado-Garcia, Richard M. Harland, Michael J. Abrams
Developmental biology requires rapid embryo injections and screening. We applied new affordable high-resolution 3D-printing to create five easily modifiable stamp-mold tools that greatly increase injection and screening speed, while simultaneously reducing the harmful aspects of these processes. We designed two stamps…
Tyler S. Laird, Kevin Flyangolts, Craig Bartling, Bryan T. Gemler + 14 more
Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious intent to cause harm. Thus, this technology needs to be…
Phil Palmer, Nikki Teran, Nicole Wheeler, Jaime Yassif
As biological AI models become more powerful, practical biosecurity approaches are needed to support beneficial applications while reducing misuse risks. Sequence-similarity-based screening approaches are no longer adequate to safeguard biological AI models because these models can design molecules with novel sequences…
Andrew N Tolopko, John P Sullivan, Sean D Erickson, David Wrobel + 8 more
Background Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access…
Alan Roger Santos-Silva, Joel B. Epstein, Luiz P. Kowalski, Thaís Cristina Esteves-Pereira + 5 more
Title: Simple Summary Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, with a disproportionate burden in low- and middle-income countries and among underserved populations in high-income settings. Tobacco and alcohol consumption are historically the primary risk factors, and primary…
Hyun-Hwan Jeong, Seon Young Kim, Maxime WC Rosseaux, Huda Y Zoghbi + 1 more
We present a user-friendly, cloud-based, data analysis pipeline for the deconvolution of pooled screening data. This tool, termed SAVE for Screening Analysis Visual Explorer, serves a dual purpose of extracting, clustering and analyzing raw next generation sequencing files derived from pooled screening experiments…
Halim Abbas, F. Garberson, Eric Glover, Dennis P. Wall
Existing screening tools for early detection of autism are expensive, cumbersome, time-intensive, and sometimes fall short in predictive value. In this work, we apply Machine Learning (ML) to gold standard clinical data obtained across thousands of children at risk for autism spectrum disorders to create a low-cost…
Sabine Baker, Danielle Gallegos, Megan A. Rebuli, Amanda J. Taylor + 2 more
'Ray Mahoney' 'Keturah R. Faurot'] Household food insecurity has significant negative implications across the lifespan. While routine screening is recommended, particularly in healthcare, guidelines are lacking on selection of screening tools and best-practice implementation across different contexts in…
Aleksi Huotala, Miikka Kuutila, Paul Ralph, Mika Mäntylä
Process of Systematic Reviews Authors: ['Aleksi Huotala' 'Miikka Kuutila' 'Paul Ralph' 'Mika Mäntylä'] Context: Systematic review (SR) is a popular research method in software engineering (SE). However, conducting an SR takes an average of 67 weeks. Thus, automating any step of the SR process could reduce the effort…
Antoine Lacour, Hamza Ibrahim, Andrea Volkamer, Anna K. H. Hirsch
In this study, we introduce DockM8, an innovative open-source platform designed for consensus virtual screening in drug design. Leveraging various docking algorithms and scoring functions, DockM8 provides a highly customizable workflow for structure-based virtual screening. In rigorous evaluations across the DEKOIS…
Shanmukh Reddy Manne, Kiran Kumar Vupparaboina, Gowtham Chowdary Gudapati, Ram Anudeep Peddoju + 5 more
'Gowtham Chowdary Gudapati' 'Ram Anudeep Peddoju' 'Chandra Prakash Konkimalla' 'Abhilash Goud' 'Sarforaz Bin Bashar' 'Jay Chhablani' 'Soumya Jana'] Background and Objective: A variety of vision ailments are associated with geographic atrophy (GA) in the foveal region of the eye. In current clinical practice, the…
Authors not listed
Shinyscreen is an R package and Shiny-based web application designed for the exploration, visualization, and quality assessment of raw data from high resolution mass spectrometry instruments. Its versatile compound or mass list-based approach supports the curation of data starting from either known or “suspected”…
Davide Boldini, Lukas Friedrich, Daniel Kuhn, Stephan Sieber
Efficient prioritization of bioactive compounds from high throughput screening campaigns is a fundamental challenge for accelerating drug development efforts. In this study, we present the first data-driven approach to simultaneously detect assay interferents and prioritize true bioactive compounds. By analyzing the…
Justus T. Metternich, Sujit K. Patjoshi, Tanuja Kistwal, Sebastian Kruss
Optical sensors/probes are powerful tools to identify and image (biological) molecules. Because of their optoelectronic properties, nanomaterials are often used as building blocks. Such nanosensors are assembled from an optically sensitive nanomaterial, a (biological) recognition unit, and linker chemistry that…
Minhaj Nur Alam, David Le, Jennifer I. Lim, R.V. Paul Chan + 1 more
'Xincheng Yao'] Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical…
Marcia Russell
Over the years, the methods employed to develop evidence-based guidelines for clinical practice have matured. To take full advantage of these advances, the current USPSTF formed a methods subcommittee, the Methods Work Group, to evaluate procedures that were used to develop recommendations and to identify issues for…
Juerg Straubhaar, Alexandria D’Souza, Zachary Niziolek, Bogdan Budnik
Single-cell analysis has clearly established itself in biology and biomedical fields as an invaluable tool that allows one to comprehensively understand the relationship between cells, including their types, states, transitions, trajectories, and spatial position. Scientific methods such as fluorescence labeling…
Mingze Bai, Jingwen Deng, Chengxin Dai, Julianus Pfeuffer + 1 more
Testing for significant differences in quantities on protein level is a common goal of many LFQ-based mass spectrometry proteomics experiments. Starting from a table of protein and/or peptide quantities from a fixed proteomics quantification software, there exists a multitude of tools and R packages to perform the…
Thanh Nguyen, Luiz Fernando F. P. de Lima, Maria Teresa Badassarre, Ronnie de Souza Santos
Software Industry Adoption Authors: ['Thanh Nguyen' 'Luiz Fernando F. P. de Lima' 'Maria Teresa Badassarre' 'Ronnie de Souza Santos'] Context: The increasing integration of artificial intelligence and machine learning into software systems has highlighted the critical importance of ensuring fairness in these…
Francesca Farina, Nicola Cirillo, I-Ta Lee
Title: Simple Summary This article discusses the potential benefits and limitations of oral cancer screening. While early detection can be beneficial, there is limited evidence that screening programs significantly reduce deaths from oral cancer. The issue lies partly in how the effectiveness of screening programs is…