11 papers · ranked by Valyu relevance
Eliezer Masliah
How transient neural representations become integrated and stable enough to function as internal neural models remains incompletely understood. Grounded in efficient coding, Bayesian and predictive frameworks, recurrent and attractor dynamics, neural state-space models, and systems neuroscience, the Principle of…
Fernando Castro‐Prado, Javier Costas, Dominic Edelmann, Wenceslao González‐Manteiga + 1 more
Understanding epistasis (genetic interaction) may shed some light on the genomic basis of common diseases, including disorders of maximum interest due to their high socioeconomic burden, like schizophrenia. Distance correlation is an association measure that characterizes general statistical independence between random…
Lianne Gahan, Adélaïde Raguin, Partho Sakha De
Lignin’s complex and highly branched architecture plays a critical role in biomass utilisation. Yet, unravelling the intricate relation between lignin’s measurable structural features and the underlying biosynthesis dynamics remains a major challenge. This difficulty stems from the variability in monolignol and bond…
Daniel S. Malawsky, Laura Hegemann, Olivia Wootton, Alexandra Karoline Havdahl + 2 more
Parental genotypes may influence offspring outcomes through the environments parents provide, a process known as genetic nurture, but estimating such effects from polygenic scores is complicated jointly by measurement error, unobserved genetic variation, and assortative mating. Here, we introduce RAVEL, a structural…
Xiaoyue Hu, Yuhao Ma, Ruixing Ming, Heping Zhang + 1 more
Identifying essential biomarkers remains a core challenge in elucidating the pathogenic mechanisms and achieving precise diagnosis of complex diseases. Deep neural networks offer immense predictive power, yet their lack of interpretability severely limits downstream biological insight. Here, we introduce DeepVaris, an…
Alexei Iakhiaev
Tissue Factor (TF) is a tightly regulated transmembrane protein that maintains its encrypted state on the cell surface with an unknown conformation. Generation of TF conformational ensembles by the co-folding method using alphafold3 and boltz2 software revealed two mechanisms of TF self-regulation and corresponding…
Wouter Muijres, Maarten Afschrift, Renaud Ronsse, Tom Van Wouwe + 1 more
The high metabolic cost of walking in individuals with a transtibial amputation is often attributed to reduced ankle propulsion. However, the cost of stabilizing walking may also increase after amputation, potentially explaining why restoring ankle propulsion does not always normalize metabolic cost. Because the…
Cristiano Ialongo
Title: Graphical abstract
Manasi Bora, Prokriti Paul, Sanchaita Rajkhowa, Harshita Sonar + 4 more
The rapid rise of multidrug-resistant (MDR) Klebsiella pneumoniae has created a major global health challenge due to the limited availability of conserved therapeutic targets effective across diverse resistant strains. In this study, an integrative computational target-discovery and drug-repurposing framework was…
Yanick Aqua Stong Tangan, G Takop Nchanji, Marcel Nyuylam Moyeh, Teke Mary Efeti + 15 more
Hookworm disease, primarily caused by Necator americanus, affects about 472 million people worldwide and contributes substantially to global disease burden, yet no approved vaccine is currently available. The clinical failure of Na-ASP-2 protein due to IgE-mediated hypersensitivity highlights the need for safe…
Bach Tran Nguyen, Aurélie Barrail-Tran, Moreno Ursino, Sébastien Goutal + 6 more
First-in-human studies require dose extrapolation from pharmacokinetic animal studies combined with safety assessments. Subtherapeutic doses of radiolabelled drugs can be administered in preclinical and early clinical development to gain a dynamic pharmacokinetic understanding, potentially informing…