25 papers · ranked by Valyu relevance
Greg Wilson, Francis Ouellette
While the final design should be leveled, the process used to create it almost certainly won’t be. Studies of expert designers have found that they constantly drill down from high-level ideas to concrete implications to find out whether their plan will work or not . Replacing a low-level test with a function as shown…
Reza Rahimi
It could be understood from the above definition that to design something related to make artifacts which could be used for special purpose. In brief the purpose of design is to produce a solution to the problem. Another interesting point about the root of the word design is its relation to the word signature. One…
Aydin Homay
—Design is a fundamental aspect of engineering, enabling the creation of products, systems, and organizations to meet societal and/or business needs. However, the absence of a scientific foundation in design often results in subjective decision-making, reducing both efficiency and innovation. This challenge is…
Sabah Al‐Fedaghi
—From a software design perspective, a clear definition of design can enhance project success and development productivity. Even though the focus is on software engineering, in this paper, we view the notion of design from the wider point of view of poiesis, the field of the study of the phenomena of creation and…
Paul Ralph
Understanding software design practice is critical to understanding modern information systems development. New developments in empirical software engineering, information systems design science and the interdisciplinary design literature combined with recent advances in process theory and testability have created a…
Christopher L. Simons, Ian C. Parmee
—Design is fundamental to software development but can be demanding to perform. Thus to assist the software designer, evolutionary computing is being increasingly applied using machine-based, quantitative fitness functions to evolve software designs. However, in nature, elegance and symmetry play a crucial role in the…
Maria Anjum, David Budgen, Le Zhang
Software services offer the opportunity to use a component-based approach for the design of applications. However, this needs a deeper understanding of how to develop service-based applications in a systematic manner, and of the set of properties that need to be included in the ‘design model’. We have used a realistic…
Eda Ozcan, Damla Topalli, Gul Tokdemir, Nergiz Ercil Cagiltay + 1 more
'Luca Ardito'] System design is recognized as one of the most critical components of a software system that bridges system requirements and coding. System design also has a significant impact on testing and maintenance activities, and on further improvements during the lifespan of the software system. Software design…
Casey Grun, Justin Werfel, David Yu Zhang, Peng Yin
Dynamic DNA nanotechnology provides a promising avenue for implementing sophisticated assembly processes, mechanical behaviours, sensing and computation at the nanoscale. However, design of these systems is complex and error-prone, because the need to control the kinetic pathway of a system greatly increases the number…
Falk Schreiber, Tobias Czauderna, Dimitar Garkov, Niklas Gröne + 4 more
'Karsten Klein' 'Matthias Lange' 'Uwe Scholz' 'Björn Sommer'] Title: Abstract Sustainable software development requires the software to remain accessible and maintainable over long time. This is particularly challenging in a scientific context. For example, fewer than one third of tools and platforms for biological…
Federico Cabitza, Carla Simone
As often reported in the specialist literature in the last thirty years or so, and even recently (e.g., Lyytinen and Robey, 1999; Shapiro, 2005; Pan et al, 2008; Warkentin et al, 2009) with a tinge of disgruntled resignation, approximately half to two-thirds (if not more) Information Systems (IS) projects fail. Of…
George Dimitriadis, Ella Svahn, Andrew MacAskill, Athena Akrami
To realise a research project idea, an experimenter faces a series of conflicting design and implementation considerations, regarding both its hardware and software components. For instance, the ease of implementation, in time and expertise, should be balanced against the ease of future reconfigurability and number of…
Thomas A. Hopf, Artem Gazizov, Sergio Garcia Busto, Ethan Eschbach + 9 more
Machine learning methods for protein engineering are rarely interoperable, require bespoke workflows, and remain inaccessible to non-experts. Yet the design problems that matter most – conditional design subject to real-world constraints, multi-objective optimization, and iterative lab-in-the-loop workflows where…
Evgeny Pyshkin
This paper follows a discourse on software recognized as a product of art and human creativity progressing probably for as long as software exists. A retrospective view on computer science and software philosophy development is introduced. In so doing we discover parallels between software and various branches of human…
Jonas Schaub, Julian Zander, Achim Zielesny, Christoph Steinbeck
The concept of molecular scaffolds as defining core structures of organic molecules is utilised in many areas of chemistry and cheminformatics, e.g. drug design, chemical classification, or the analysis of high-throughput screening data. Here, we present Scaffold Generator, a comprehensive open library for the…
Nathan Braniff, Taylor Pearce, Zixuan Lu, Michael Astwood + 3 more
Modelling in systems and synthetic biology relies on accurate parameter estimates and predictions. Accurate model calibration relies, in turn, on data, and on how well-suited the available data is to a particular modelling task. Optimal experimental design (OED) techniques can be used to identify experiments and data…
Tristan Zaborniak, Noora Azadvari, Qiyao Zhu, S.M. Bargeen A. Turzo + 3 more
Although canonical protein design has benefited from machine learning methods trained on databases of protein sequences and structures, synthetic heteropolymer design still relies heavily on physics-based methods. The Rosetta software, which provides diverse physics-based methods for designing sequences, exploring…
Miguel Á. Valderrama-Gómez, Jason G. Lomnitz, Rick A. Fasani, Michael A. Savageau
Mechanistic models of biochemical systems provide a rigorous kinetics-based description of various biological phenomena. They are indispensable to elucidate biological design principles and to devise and engineer systems with novel functionalities. To date, mathematical analysis and characterization of these models…
Authors not listed
In experimental chemistry, actions are adjusted based on what we see—such as dosing until dissolution, heating until melting, or stirring until mixing is complete. However, current self-driving labs (SDLs) do not monitor these visual cues. HeinSight 4.0 fills this gap by integrating computer vision into SDLs to enable…
Lucas P. Merlicek, Jannik Neumann, Abbie Lear, Vivian Degiorgi + 4 more
The ability to create new-to-nature enzymes would substantially advance bioengineering, medicine, and the chemical industry. Despite recent breakthroughs in protein design and structure prediction, designing biocatalysts with activities rivaling those of natural enzymes remains challenging. Here, we present AI.zymes, a…
Erin Looney, Andre Buscariolli, Maria Yang, Geoffrey Raymond + 2 more
Hardware-based startups risk having longer times-to-market, deterring investment in critical fields such as cleantech, medical devices, and automation. We interviewed 55 leaders at hardware startups, mapped their development timelines, and found prototyping to be the longest development step (median of 19 weeks per…
Anna Matuszyńska, Oliver Ebenhöh, Matias D. Zurbriggen, Daniel C. Ducat + 1 more
Synthetic biology designs and constructs new biological parts, devices and systems with predetermined functionalities. With the unlimited ability to synthesise any DNA and RNA and transfer it to almost any organism, we are at the dawn of a new era in which biology is being recreated in ways never before possible. It…
Thomas Scott, Christian Alan Paul Smethurst, Yvonne Westermaier, Moriz Mayer + 22 more
Given the role of human intuition in current drug design efforts, crowd-sourced 'citizen scientist' games have the potential to greatly expand the pool of potential drug designers. Here, we introduce ‘Drugit', the small molecule design mode of the online ‘citizen science’ game Foldit. We demonstrate its utility for…
Yan C. Leyva, Marcelo D. T. Torres, Carlos A. Oliva, Cesar de la Fuente-Nunez + 1 more
Computational protein and peptide design is emerging as a transformative framework for engineering macromolecules with precise structures and functions, offering innovative solutions in medicine, biotechnology, and materials science. However, current methods predominantly rely on generative models, which are expensive…
Aniket Chitre, David Woods, Alexei Lapkin
Liquid formulations design typically involves searching a high-dimensional space, owing to the combinatorial selection of ingredients from a larger subset of available ingredients, with a relatively limited experimental budget. Therefore, we need to efficiently select the most informative experiments. These experiments…