22 papers · ranked by Valyu relevance
George W Breslauer, Kenneth J Breslauer, Yannis Yortsos
A biophysical chemist and a political scientist team up to explore striking parallels between the requisites of “stability” and the causes of instability within both the cellular/molecular world of biophysical chemistry and the world of social and political organization of self-assembled, societal structures, such as…
Giuseppe Destefanis, Silvia Bartolucci, Daniel Graziotin, Rumyana Neykova + 1 more
'Rumyana Neykova' 'Marco Ortu'] Drawing from engineering systems and control theory, we introduce a framework to understand repository stability, which is a repository activity capacity to return to equilibrium following disturbances - such as a sudden influx of bug reports, key contributor departures, or a spike in…
Zachary C Williams, Dylan E McNamara
Empirical diagnosis of stability has received considerable attention, often focused on variance metrics for early warning signals of abrupt system change or delicate techniques measuring Lyapunov spectra. The theoretical foundation for the popular early warning signal approach has been limited to relatively simple…
Hendrik Reimann, Sjoerd M. Bruijn
The walking human body is mechanically unstable. Loss of stability and falling is more likely in certain groups of people, such as older adults or people with neuromotor impairments, as well as in certain situations, such as when experiencing conflicting or distracting sensory inputs. Stability during walking is often…
J. A. Scott Kelso
Multistable coordination dynamics exists at many levels, from multifunctional neural circuits in vertebrates and invertebrates to large-scale neural circuitry in humans. Moreover, multistability spans (at least) the domains of action and perception, and has been found to place constraints upon, even dictating the…
Jean‐François Arnoldi, Bart Haegeman
We exhibit a fundamental relationship between measures of dynamical and structural stability of equilibriums, arising from real dynamical systems. We show that dynamical stability, quantified via systems local response to external perturbations, coincides with the minimal internal perturbation able to destabilize the…
Kasper Tolborg, Johan Klarbring, Alex M. Ganose, Aron Walsh
What is the likelihood that a hypothetical material - the combination of a composition and crystal structure - can be formed? Underpinning the reliability of predictions for local or global crystal stability is the choice of thermodynamic potential. Here, we discuss recent advances in free energy descriptions for…
ZbigniewBartosiewicz
It is shown that a positive linear system on a time scale with a bounded graininess is uniformly exponentially stable if and only if the characteristic polynomial of the matrix defining the system has all its coefficients positive. Then this fact is used to find necessary and sufficient conditions of positive…
Susanne Pettersson, Van M. Savage, Martin Nilsson Jacobi
Dynamical shifts between the extremes of stability and collapse are hallmarks of ecological systems. These shifts are limited by and change with biodiversity, complexity, and the topology and hierarchy of interactions. Most ecological research has focused on identifying conditions for a system to shift from stability…
Yong Tan, André Platzer
Stability is required for real world controlled systems as it ensures that those systems can tolerate small, real world perturbations around their desired operating states. This paper shows how stability for continuous systems modeled by ordinary differential equations (ODEs) can be formally verified in differential…
Vijay M. Tangde, Anil A. Bhalekar, Bjarne Andresen, Miguel Rubi
Three approaches for determining the thermodynamic stability of irreversible processes are described in generalized formulations. The simplest is the Gibbs-Duhem theory, specialized to irreversible trajectories, which uses the concept of virtual displacement in the reverse direction. Its only drawback is that even a…
Anne Chao, Robert K. Colwell, Johnny Shia, Simon Thorn + 12 more
When biodiversity–stability relationships are assessed from temporal patterns of species (or species assemblages) biomass or other key variables, ecological stability is commonly quantified as the inverse of the coefficient of variation (CV) or its square. However, just as biodiversity cannot be fully characterized by…
Veerupaksh Singla, Qiyuan Zhao, Brett Savoie
The absence of computational methods to predict stressor-specific degradation susceptibilities represents a significant and costly challenge to the introduction of new materials into applications. Here, a machine-learning framework is developed that predicts stressor-specific stability scores from computationally…
Jonathan Fine, Prageeth R Wijewardhane, Sheik Dawood Beer Mohideen, Katelyn Smith + 6 more
Chemical and physical stabilities are two key features considered in pharmaceutical development. Chemical stability is typically reported as a combination of potency and degradation product. For peptide products, it is common to measure physical stability via aggregation or fibrillation using the fluorescent reporter…
Jean-François Arnoldi, Michel Loreau, Bart Haegeman
Empirical knowledge of ecosystem stability and diversity-stability relationships is mostly based on the analysis of temporal variability of population and ecosystem properties. Variability, however, often depends on external factors that act as disturbances, making it difficult to compare its value across systems and…
Charlotte Kunze, Dominik Bahlburg, Maren Striebel, Toni Schott + 2 more
Understanding the relationship between biodiversity and both the functioning and stability of ecosystems has been a central focus of ecologists for decades. A step-change in our understanding of the biodiversity–ecosystem functioning relationship was enabled by explicit measurement of the additional functioning…
Jing Ling, Yong Du, W. Peter Wuelfing, Nicole Buist + 4 more
Protein drugs exhibit challenges of biophysical and biochemical instability due to their structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by increasing molecular rigidity within the formulation matrix, representing a primary category of drug products alongside sterile liquid…
Paul Kirk, Delphine Rolando, Adam L. MacLean, Michael P. H. Stumpf
There has been a long-standing and at times fractious debate whether complex and large systems can be stable. In ecology, the so-called 'diversity-stability debate' [1] arose because mathematical analyses of ecosystem stability were either specific to a particular model (leading to results that were not general), or…
Alexander Alecio
We consider a model for systemic risk comprising of a system of diffusion processes, interacting through their empirical mean. Each process is subject to a confining double-well potential with some uncertainty in the coefficients, corresponding to fluctuations in height of the potential barrier seperating the two…
Authors not listed
Free energy calculations based on molecular dynamics simulations offer a quantitative assessment of biomolecule binding and stability. This chapter discusses accurately estimating the free energy differences employing nonequilibrium alchemy. We cover the theoretical background, technical aspects of free energy…
Yoshiharu Mukouyama, Kenya Tanaka, Shuji Nakanishi, Yoshihiro Nakato
The present work reveals that a prebiotic chemical system can generate self-organizing ability that leads to highly ordered structures and an active character such as free independent harmonious behavior. This result is the properties of natural things that have long been overlooked since Darwin’s theory of evolution…
John G. Milton, Toru Ohira, Juan Luis Cabrera, Ryan M. Fraiser + 7 more
Stick balancing at the fingertip is a powerful paradigm for the study of the control of human balance. Here we show that the mean stick balancing time is increased by about two-fold when a subject stands on a vibrating platform that produces vertical vibrations at the fingertip (0.001 m, 15-50 Hz). High speed motion…