26 papers · ranked by Valyu relevance
Leili Shahriyari, Natalia L. Komarova, Aditya Bhushan Pant
Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types…
Leili Shahriyari, Natalia L. Komarova
Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types…
Yanli Wang, Wing-Cheong Lo, Ching-Shin Chou
Stem cells are important to generate all specialized tissues at an early life stage, and in some systems, they also have repair functions to replenish the adult tissues. Repeated cell divisions lead to the accumulation of molecular damage in stem cells, which are commonly recognized as drivers of ageing. In this paper…
Muhammed Burak Bener, Mayu Inaba
Asymmetric cell division (ACD) has been extensively studied in various stem cell systems as a fundamental mechanism that ensures the balance between stem cell self-renewal and differentiation. ACD allows one daughter cell to retain stem cell identity while the other commits to differentiation, thereby maintaining…
Joep Beumer, Hans Clevers
Title: Summary All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to…
Valerio Lupperger, Carsten Marr, Prisca Chapouton, Catarina C. Homem
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, are poorly understood. In particular, it is unclear how the activity of single stem cells is coordinated within the population or if cells divide in a purely random fashion. We…
Ben D MacArthur, Philip Greulich
To self-renew, stem cells must precisely balance proliferation and differentiation. Typically this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic self-renewal program that allows them to do so autonomously, if required. However, because self-renewal implies a stable equilibrium…
Fumio Arai, Patrick S. Stumpf, Yoshiko M. Ikushima, Kentaro Hosokawa + 4 more
Changes in the ability of individual stem cells to self-renew based on their developmental history may underpin aging. Here, we developed a high-throughput paired daughter cell assay that combines single cell profiling with machine learning and mathematical modeling to probe in detail how multivariate gene expression…
Zhijie Wu, Yuman Wang, Kun Wang, Da Zhou
In order to fulfill cell proliferation and differentiation through cellular hierarchy, stem cells can undergo either asymmetric or symmetric divisions. Recent studies pay special attention to the effect of different modes of stem cell division on the lifetime risk of cancer, and report that symmetric division is more…
Haim Bar, Huyen N. Nguyen, Joanne C. Conover
Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in adulthood to support tissue regenerative capabilities. This property of stemness…
Leili Shahriyari, Ali Mahdipour–Shirayeh
Studying the stem cell niche architecture is a crucial step for investigating the process of oncogenesis and obtaining an effective stem cell therapy for various cancers. Recently, it has been observed that there are two groups of stem cells in the stem cell niche collaborating with each other to maintain tissue…
Lisa Van den Broeck, Ryan J. Spurney, Adam P. Fisher, Michael Schwartz + 6 more
'Michael Schwartz' 'Natalie M. Clark' 'Thomas T. Nguyen' 'Imani Madison' 'Mariah Gobble' 'Terri Long' 'Rosangela Sozzani'] Stem cells give rise to the entirety of cells within an organ. Maintaining stem cell identity and coordinately regulating stem cell divisions is crucial for proper development. In plants, mobile…
Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý + 2 more
'Eva Benková' 'Jiří Friml'] Title: Summary Patterning in plants relies on oriented cell divisions and acquisition of specific cell identities. Plants regularly endure wounds caused by abiotic or biotic environmental stimuli and have developed extraordinary abilities to restore their tissues after injuries. Here, we…
Huyen T. K. Nguyen, Haim Bar, Zhiyi Chi, Vladimir Pozdnyakov
Stem cells, through their ability to produce daughter stem cells and differentiate into specialized cells, are essential in the growth, maintenance, and repair of biological tissues. Understanding the dynamics of cell populations in the proliferation process not only uncovers proliferative properties of stem cells, but…
Sahand Hormoz
Cycling tissues such as the intestinal epithelium, germ line, and hair follicles, require a constant flux of differentiated cells. These tissues are maintained by a population of stem cells, which generate differentiated progenies and self-renew. Asymmetric division of each stem cell into one stem cell and one…
Najme Khorasani, Mehdi Sadeghi, Abbas Nowzari-Dalini
Stem cells, with their capacity to self-renew and to differentiate to more specialized cell types, play a key role to maintain homeostasis in adult tissues. To investigate how, in the dynamic stochastic environment of a tissue, non-genetic diversity and the precise balance between proliferation and differentiation are…
Amit Jangid, Suriya Selvarajan, Ram Ramaswamy
We study a population based cellular model starting from a single stem cell which stochastically divides to give rise to either daughter stem cells or differentiated daughter cells. There are three main components in the model: nucleus position, gene-regulatory network, and stochastic segregation of transcription…
Derek C. H. Chan, Ana Vujovic, Joshua Xu, Victor Gordon + 9 more
How hematopoietic stem cells (HSCs) coordinate their divisional axis relative to supportive niche cells and whether or not their divisional orientation is important for stem cell-driven hematopoiesis is poorly understood. Single cell RNA sequencing data from patients with the inherited bone marrow failure…
Jinzhi Lei
Stem cell regeneration is a crucial biological process for most selfrenewing tissues during the development and maintenance of tissue homeostasis. In developing the mathematical models of stem cell regeneration and tissue development, cell division is the core process connecting different scale biological processes and…
Dominic K Devlin, Austen RD Ganley, Nobuto Takeuchi
Morphogenesis of complex body shapes is reproducible despite the noise inherent in the underlying morphogenetic processes. However, how these morphogenetic processes work together to achieve this reproducibility remains unclear. Here, we ask how morphogenetic reproducibility is realised by developing a computational…
Authors not listed
Vertex models have been established as powerful tools for the cell-based simulation of epithelial tissues as they allow a detailed description of their mechanical development with respect to the properties of individual cells. Thus, they suit the challenges of simulating intestinal organoids which arise from the…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Tomoya Maruyama, Jing Gong, Masahiro Takinoue
Bio-soft matter droplets formed via liquid-liquid phase separation (LLPS) of biopolymers have been found in living cells. Synthetic LLPS droplets have recently been employed in nanobiotechnology for artificial cell construction, molecular robotics, molecular computing, diagnosis, and therapeutics. Controlling the…
Authors not listed
The advancement of the cell-culture industry toward a circular bioeconomy is driving a growing demand for simple and cost-effective analytical technologies to support the quality control of culture media. Here, we present a hypothesis-free, data-driven sensing strategy that employs an array of synthetic polymer probes…