24 papers · ranked by Valyu relevance
Wojciech Zakrzewski, Maciej Dobrzyński, Maria Szymonowicz, Zbigniew Rybak
'Zbigniew Rybak'] In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The…
Ioannis Alexandros Charitos, Andrea Ballini, Stefania Cantore, Mariarosaria Boccellino + 6 more
'Mariarosaria Boccellino' 'Marina Di Domenico' 'Elisa Borsani' 'Riccardo Nocini' 'Michele Di Cosola' 'Luigi Santacroce' 'Lucrezia Bottalico'] Stem cells can be used to replace damaged cells or regenerate organs and have broadened our knowledge of the development and progression of certain diseases. Despite significant…
Antonio Liras
There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells, both embryonic as adult stem cells, for several therapeutic indications (cardiovascular and ischemic diseases, diabetes, hematopoietic diseases, liver…
Roopa R Nadig
While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the…
Afsoon Aghlmandi, Aylin Nikshad, Reza Safaralizadeh, Majid Ebrahimi Warkiani + 2 more
'Majid Ebrahimi Warkiani' 'Leili Aghebati-Maleki' 'Mehdi Yousefi'] The recent years have been passed with significant progressions in the utilization of microfluidic technologies for cellular investigations. The aim of microfluidics is to mimic small-scale body environment with features like optical transparency.…
Maria Elena Padín-Iruegas, Rafael López López
Stem cells are a scientific field of interest due to their therapeutic potential. There are different groups, depending on the differentiation state. We can find lonely stem cells, but generally they distribute in niches. Stem cells don't survive forever. They are affected for senescence. Cancer stem cells are best…
Sumit Gautam, Neeraj Verma, Siddharth Manvati, Pawan K. Dhar
Stem cells are extraordinary cells with a unique ability of self-renewal and differentiation into various cell types such as muscle, nerve, bone, and blood cells. Historically, they have found significant applications in the biotech and pharma sectors. To grow and maintain stem cells artificially, researchers use basal…
Alireza Ebrahimi, Hanie Ahmadi, Zahra Pourfraidon Ghasrodashti, Nader Tanideh + 4 more
'Nader Tanideh' 'Reza Shahriarirad' 'Amirhossein Erfani' 'Keivan Ranjbar' 'Soheil Ashkani-Esfahani'] Title: ABSTRACT Stem cell therapy has been used to treat several types of diseases, and it is expected that its therapeutic uses shall increase as novel lines of evidence begin to appear. Furthermore, stem cells have…
Haim Bar, Huyen N. Nguyen, Joanne C. Conover
Stem cells are characterized by their ability to self-renew, as well as to differentiate and give rise to new populations of cells. Stem cell divisions are crucial for generative processes that occur during early development, and later in adulthood to support tissue regenerative capabilities. This property of stemness…
Mashal Daud, Zaina Sajid, Tooba Ali
The utilization of stem cells (SCs) has led the way into a new era of therapeutics known as regenerative medicine. Their renewal property offers exciting possibilities in reversing tissue damage caused by metabolic and degenerative changes. Research should be conducted increasingly to explore the possibilities of SC…
Eric Werner
We present a general computational theory of stem cell networks and their developmental dynamics. Stem cell networks are special cases of developmental control networks. Our theory generates a natural classification of all possible stem cell networks based on their network architecture. Each stem cell network has a…
Ren-Yi Sun, Michael H. Heggeness, Tanghong Jia, Sunaina Shrestha + 2 more
We have recently identified a population of cells within the peripheral nerves of adult mice that can respond to BMP-2 exposure or physical injury to rapidly proliferate. More importantly, these cells exhibited embryonic differentiation potentials that could be induced into osteoblastic and endothelial cells in vitro.…
Divyanjali Shanmuganathan, Nivethika Sivakumaran
In the middle of the last century, it has been known that neural stem cells (NSCs) play a key role in regenerative medicine to cure the neurodegenerative disease. This review article covers about the introduction to neural stem cell biology and the isolation, differentiation and transplantation methods/techniques of…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Xuelian Su, Jizeng Wang, Guangjie Bao, Haijing Zhou + 4 more
Stem cell apoptosis exists widely in embryonic development, tissue regeneration, repair, aging and pathophysiology of disease. The molecular mechanism of stem cell apoptosis has been extensively investigated. However, alterations in biomechanics and nanomorphology have rarely been studied. Therefore, an apoptosis model…
Myret Ghabriel, Ahmed El Hosseiny, Ahmed Moustafa, Asma Amleh
Mesenchymal stromal/stem cells (MSCs) are multipotent cells residing in multiple tissues with the capacity for self-renewal and differentiation into various cell types. These properties make them promising candidates for regenerative therapies. MSC identification is critical in yielding pure populations for successful…
Eric Werner
Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different from normal stem cells. The difference between cancer stem…
Nivethika Sivakumaran, Imesha Rashmini Rathnayaka, Rashida Shabbir, Sasini Sandareka Wimalsinghe + 4 more
'Sasini Sandareka Wimalsinghe' 'J. A. Sumalimina Jayakody' 'Mahisha Chandrasekaran' 'Mawatha' 'Sri Lanka'] Cord Blood Banking (CBB) is the storing of the umbilical cord blood which is collected immediately after the delivery of the baby. Great care and concern is needed for proper storage of these progenitor cells…
Hannah Donnelly, Ewan Ross, Yinbo Xiao, Rio Hermantara + 15 more
Long-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via allogeneic stem cell transplantation (alloSCT), to engraft and repopulate the blood system. The very low abundance of LT-HSCs and their rapid differentiation during in vitro culture hinders their clinical utility.…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Authors not listed
The advancement of the cell-culture industry toward a circular bioeconomy is driving a growing demand for simple and cost-effective analytical technologies to support the quality control of culture media. Here, we present a hypothesis-free, data-driven sensing strategy that employs an array of synthetic polymer probes…
Lixia Wang, Gang Jin, Qiuping Zhou, Yanyan Liu + 4 more
Long-term antitumor efficacy of chimeric antigen receptor (CAR)-T cells depends on their functional persistence in vivo. T cells with stem-like property show better persistence, but factors conferring T cells bona fide stemness remain to be determined. Here, we demonstrate the induction of CAR-T cells into an…
Authors not listed
In this report, we examine the extensive research landscape of CRISPR with an emphasis on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up-to-date scientific information consisting of more than 53,000 publications encompassing academic journal articles and patents, spanning nearly…