21 papers · ranked by Valyu relevance
Lucie Laplane, Eric Solary
The characteristic properties of stem cells - notably their ability to self-renew and to differentiate - have meant that they have traditionally been viewed as distinct from most other types of cells. However, recent research has blurred the line between stem cells and other cells by showing that the former display a…
Tânia Barata, Isabel Duarte, Matthias E. Futschik, Allison D. Ebert
Stem cells encompass a variety of different cell types which converge on the dual capacity to self-renew and differentiate into one or more lineages. These characteristic features are key for the involvement of stem cells in crucial biological processes such as development and ageing. To decipher their underlying…
Alex Miranda, Phineas T Hamilton, Allen W Zhang, Etienne Becht + 5 more
Regulatory programs that control the function of stem cells are active in cancer and confer properties that promote progression and therapy resistance. However, the impact of a stem cell-like tumor phenotype (“sternness”) on the immunological properties of cancer has not been systematically explored. Using gene…
Weiwei Zhou, Minghai Su, Tiantongfei Jiang, Yunjin Xie + 6 more
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features, which are potential culprit in immunotherapy resistance. Although the state-of-art predictive computational methods have facilitated predicting the cancer stemness, currently there is no…
Min Zhang, Yang Liu, Lihua Shi, Lei Fang + 2 more
Tumorigenicity and pluripotent differentiation potential are kernel cell properties for tumorgenesis and embryogenesis. A growing number of studies have demonstrated that neural stemness is the source of the two cell properties, because neural stem cells and cancer cells share cell features and regulatory networks and…
LE. Carter, DP. Cook, CW. McCloskey, T. Dang + 4 more
The ovarian surface epithelium (OSE) is a monolayer of epithelial cells covering the surface of the ovary. During ovulation, the OSE is ruptured to allow release of the oocyte. This wound is quickly repaired, but mechanisms of this repair are poorly understood. The contribution of tissue-resident stem cells in the…
Tasnim Zerin, Paola Ruiz-Duarte, Ann-Kathrin Schürholz, Theresa Schlamp + 9 more
At the basis of plant developmental plasticity are continuously active pluripotent stem cells, which fuel the life-long post-embryonic formation of new organs. Since plant cells are encased in cell walls and thus immotile, their individual fate-specification program is dependent on their relative position within the…
Leili Shahriyari, Natalia L. Komarova
Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types…
Debee Prasad Sahoo, Lon J. Van Winkle, Rocío I. Díaz de la Garza, Joseph G. Dubrovsky
'Joseph G. Dubrovsky'] In multicellular organisms, tissue generation, maintenance, and homeostasis depend on stem cells. Cellular metabolic status is an essential component of different differentiated states, from stem to fully differentiated cells. Threonine (Thr) metabolism has emerged as a critical factor required…
Maria Elena Padín-Iruegas, Rafael López López
Stem cells are a scientific field of interest due to their therapeutic potential. There are different groups, depending on the differentiation state. We can find lonely stem cells, but generally they distribute in niches. Stem cells don't survive forever. They are affected for senescence. Cancer stem cells are best…
Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi + 4 more
'Youyuan Deng' 'Mohit Kumar Jolly' 'José N. Onuchic' 'Herbert Levine'] 1 Center for Theoretical Biological Physics, Rice University, Houston, TX 77005, USA 2 Department of Chemistry, Rice University, Houston, TX 77005, USA 3 PhD Program in Systems, Synthetic, and Physical Biology, Rice University, Houston, TX 77005…
Agata Burian
A genetic continuity of living organisms relies on the germline which is a specialized cell lineage producing gametes. Essential in the germline functioning is the protection of genetic information that is subjected to spontaneous mutations. Due to indeterminate growth, late specification of the germline, and unique…
Liu Hong, Jennifer C. Fletcher, Massimiliano Sassi, Giovanna Sessa
The development of both animals and plants relies on populations of pluripotent stem cells that provide the cellular raw materials for organ and tissue formation. Plant stem cell reservoirs are housed at the shoot and root tips in structures called meristems, with the shoot apical meristem (SAM) continuously producing…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Xi Chen, Chang Guo, Xingle Li, Meiting Wang + 2 more
The stem, a crucial organ that connects the root and aboveground parts, is responsible for transporting water and nutrients. This review synthesizes the current understanding of stem development in ornamental plants. We first outline the morphological and physiological characteristics of stem elongation and stem…
Jinzhi Lei
Stem cell regeneration is a crucial biological process for most selfrenewing tissues during the development and maintenance of tissue homeostasis. In developing the mathematical models of stem cell regeneration and tissue development, cell division is the core process connecting different scale biological processes and…
Eric Werner
Cancer stem cells are controlled by developmental networks that are often topologically indistinguishable from normal, healthy stem cells. The question is why cancer stem cells can be both phenotypically distinct and have morphological effects so different from normal stem cells. The difference between cancer stem…
Jinzhi Lei
Stem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of epigenetic states. The model generalizes the classical G0 cell cycle model, and…
Alexandra Jilkine, Ryan N. Gutenkunst
Accumulating evidence suggests that many tumors have a hierarchical organization, with the bulk of the tumor composed of relatively differentiated short-lived progenitor cells that are maintained by a small population of undifferentiated long-lived cancer stem cells. It is unclear, however, whether cancer stem cells…
Authors not listed
The demand for high-resolution imaging of nanomaterials continues to grow across disciplines. However, conventional support films for transmission and scanning transmission electron microscopy (TEM/STEM) are often limited by low beam resistance, suboptimal resolution, toxicity concerns, and high production costs. This…