11 papers · ranked by Valyu relevance
Alex Miranda, Phineas T Hamilton, Allen W Zhang, Etienne Becht + 5 more
Regulatory programs that control the function of stem cells are active in cancer and confer properties that promote progression and therapy resistance. However, the impact of a stem cell-like tumor phenotype (“sternness”) on the immunological properties of cancer has not been systematically explored. Using gene…
Weiwei Zhou, Minghai Su, Tiantongfei Jiang, Yunjin Xie + 6 more
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features, which are potential culprit in immunotherapy resistance. Although the state-of-art predictive computational methods have facilitated predicting the cancer stemness, currently there is no…
Min Zhang, Yang Liu, Lihua Shi, Lei Fang + 2 more
Tumorigenicity and pluripotent differentiation potential are kernel cell properties for tumorgenesis and embryogenesis. A growing number of studies have demonstrated that neural stemness is the source of the two cell properties, because neural stem cells and cancer cells share cell features and regulatory networks and…
LE. Carter, DP. Cook, CW. McCloskey, T. Dang + 4 more
The ovarian surface epithelium (OSE) is a monolayer of epithelial cells covering the surface of the ovary. During ovulation, the OSE is ruptured to allow release of the oocyte. This wound is quickly repaired, but mechanisms of this repair are poorly understood. The contribution of tissue-resident stem cells in the…
Michael A. Sun, Rui Yang, Heng Liu, Wenzhe Wang + 13 more
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the stemness and suppressed the propagation of primary BTIC cultures bearing PDGFRA…
Tasnim Zerin, Paola Ruiz-Duarte, Ann-Kathrin Schürholz, Theresa Schlamp + 9 more
At the basis of plant developmental plasticity are continuously active pluripotent stem cells, which fuel the life-long post-embryonic formation of new organs. Since plant cells are encased in cell walls and thus immotile, their individual fate-specification program is dependent on their relative position within the…
Ben D MacArthur, Philip Greulich
To self-renew, stem cells must precisely balance proliferation and differentiation. Typically this is achieved under feedback from the niche; yet many stem cells also possess an intrinsic self-renewal program that allows them to do so autonomously, if required. However, because self-renewal implies a stable equilibrium…
Deli Hong, Andrew J. Fritz, Kristiaan H. Finstad, Mark P. Fitzgerald + 5 more
Recent studies have revealed that mutations in the transcription factor Runx1 are prevalent in breast tumors. Yet, how loss of Runx1 contributes to breast cancer (BCa) remains unresolved. We demonstrate for the first time that Runx1 represses the breast cancer stem cell (BCSC) phenotype and consequently, functions as a…
Natalie M Clark, Eli Buckner, Adam P Fisher, Emily C Nelson + 8 more
Stem cells are responsible for generating all of the differentiated cells, tissues, and organs in a multicellular organism and, thus, play a crucial role in cell renewal, regeneration, and organization. A number of stem cell type-specific genes have a known role in stem cell maintenance, identity, and/or division. Yet…
Ernesto Llamas, Salvador Torres-Montilla, Hyun Ju Lee, María Victoria Barja + 7 more
The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues^1-3^. Protein homeostasis, or proteostasis, is required for cell function and viability^4-7^. However, the link between proteostasis and plant…
Sharma Nidhi, Liu Tie
In Arabidopsis, the genes SHOOT MERISTEMLESS (STM) and CLAVATA3 (CLV3) antagonistically regulate shoot meristem development. STM is essential for both development and maintenance of the meristem, as stm mutants fail to develop a shoot meristem during embryogenesis. CLV3, on the other hand, negatively regulates meristem…