28 papers · ranked by Valyu relevance
Karla Batista-García-Ramó, Caridad Ivette Fernández-Verdecia
How the human brain works is still a question, as is its implication with brain architecture: the non-trivial structure-function relationship. The main hypothesis is that the anatomic architecture conditions, but does not determine, the neural network dynamic. The functional connectivity cannot be explained only…
Antonín Škoch, Barbora Rehák Bučková, Jan Mareš, Jaroslav Tintěra + 5 more
'Pavel Sanda' 'Lucia Jajcay' 'Jiří Horáček' 'Filip Španiel' 'Jaroslav Hlinka'] The human brain represents a complex computational system, the function and structure of which may be measured using various neuroimaging techniques focusing on separate properties of the brain tissue and activity. We capture the…
Carolyn D. Langen, Tonya White, M. Arfan Ikram, Meike W. Vernooij + 2 more
'Wiro J. Niessen' 'Xi-Nian Zuo'] Structural and functional brain connectivity are increasingly used to identify and analyze group differences in studies of brain disease. This study presents methods to analyze uni- and bi-modal brain connectivity and evaluate their ability to identify differences. Novel visualizations…
Ronald J. Janssen, Max Hinne, Tom Heskes, Marcel A. J. van Gerven
The wiring diagram of the human brain can be described in terms of graph measures that characterize structural regularities. These measures require an estimate of whole-brain structural connectivity for which one may resort to deterministic or thresholded probabilistic streamlining procedures. While these procedures…
David Pascucci, Maria Rubega, Joan Rué-Queralt, Sebastien Tourbier + 2 more
The dynamic repertoire of functional brain networks is constrained by the underlying topology of structural connections: the lack of a direct structural link between two brain regions prevents direct functional interactions. Despite the intrinsic relationship between structural (SC) and functional connectivity (FC)…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh Haghighi + 2 more
The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical structures including…
Arzu HAS SILEMEK, Haitao Chen, Pascal Sati, Wei Gao
The brain’s white matter connections are thought to provide the structural basis for its functional connections between distant brain regions but how our brain selects the best structural routes for effective functional communications remains poorly understood. In this study, we propose a Unified Structural and…
Anand Pathak, Shakti N. Menon, Sitabhra Sinha
In order to understand the complex cognitive functions of the human brain, it is essential to study the structural macro-connectome, i.e., the wiring of different brain regions to each other through axonal pathways, that has been revealed by imaging techniques. However, the high degree of plasticity and…
Danilo Benozzo, Giorgia Baron, Ludovico Coletta, Alessandro Chiuso + 2 more
How the emergent functional connectivity (FC) relates to the underlying anatomy (structural connectivity, SC) is one of the biggest questions of modern neuroscience. At the macro-scale level, no one-to-one correspondence between structural and functional links seems to exist. And we posit that to better understand…
Oualid Benkarim, Casey Paquola, Bo-yong Park, Jessica Royer + 5 more
Ongoing brain function is largely determined by the underlying wiring of the brain, but the specific rules governing this relationship remain unknown. Emerging literature has suggested that functional interactions between brain regions emerge from the structural connections through mono-as well as polysynaptic…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh‐Haghighi + 1 more
'Christoph Simon'] The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical…
Venetia Voutsa, Demian Battaglia, Louise J. Bracken, Andrea Brovelli + 21 more
'Julia Costescu' 'Mario Díaz Muñoz' 'Brian D. Fath' 'Andrea Funk' 'Mel Guirro' 'Thomas Hein' 'Christian Kerschner' 'Christian Kimmich' 'Vinícius Lima' 'Arnaud Messé' 'Anthony J. Parsons' 'John Perez' 'Ronald Pöppl' 'Christina Prell' 'Sonia Recinos Brizuela' 'Yanhua Shi' 'Shubham Tiwari' 'Laura Turnbull' 'John…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh Haghighi + 1 more
The underlying anatomical structure is fundamental to the study of brain networks and is likely to play a key role in the generation of conscious experience. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical structures including the…
Richard F. Betzel
Connectomics and network neuroscience offer quantitative scientific frameworks for modeling and analyzing networks of structurally and functionally interacting neurons, neuronal populations, and macroscopic brain areas. This shift in perspective and emphasis on distributed brain function has provided fundamental…
Chirag Jain, Sravanthi Upadrasta Naga Sita, Avinash Sharma, Bapi Raju Surampudi
The intricate link between brain functional connectivity (FC) and structural connectivity (SC) is explored through models performing diffusion on SC to derive FC, using varied methodologies from single to multiple graph diffusion kernels. However, existing studies have not correlated diffusion scales with specific…
Ittai Shamir, Yaniv Assaf
Despite great progress in uncovering the complex connectivity patterns of the human brain over the last two decades, the field of connectomics still experiences a bias in its viewpoint of the cerebral cortex. Due to a lack of information regarding exact end points of fiber tracts inside cortical gray matter, the cortex…
Joseph C. Griffis, Nicholas V. Metcalf, Maurizio Corbetta, Gordon L. Shulman
Functional connectivity (FC) studies have identified physiological signatures of stroke that correlate with behavior. Using structural and functional MRI data from 114 stroke patients, 24 matched controls, and the Human Connectome Project, we tested the hypothesis that structural disconnection, not damage to critical…
Viljami Sairanen
Combining the functional and structural connectomes of the human brain on macro-scale could provide information on various brain diseases and conditions. Unfortunately, accomplishing such combination is not trivial as the connectomes are usually derived from different imaging and measuring modalities that are based on…
Jean Faber, Priscila Correia Antoneli, Guillem Via, Noemi S. Araújo + 2 more
In recent years, new and important perspectives were introduced in the field of neuroimaging with the emergence of the connectionist approach (Williams and Henson 2018). In this new context, it is important to know not only which brain areas are activated by a particular stimulus but, mainly, how these areas are…
Jui-To Wang, Ching-Po Lin, Huei-Min Liu, Carlo Pierpaoli + 1 more
Traditional brain connectivity studies have focused mainly on structural connectivity, often relying on tractography with diffusion MRI (dMRI) to reconstruct white matter pathways. In parallel, studies of functional connectivity have examined correlations in brain activity using fMRI. However, emerging methodologies…
Daniel Moyer, Boris A. Gutman, Joshua Faskowitz, Neda Jahanshad + 1 more
'Paul M. Thompson'] Abstract. We present a continuous model for structural brain connectivity based on the Poisson point process. The model treats each streamline curve in a tractography as an observed event in connectome space, here a product space of cortical white matter boundaries. We approximate the model…
Christopher Southan
This article assesses a key aspect of data sharing that has the potential to accelerate the progress and impact of medicinal chemistry. To achieve this the community needs to increase the outward flow of experimental results locked-up in millions of published PDFs into structured open databases that explicitly capture…
Mehmet Aziz Yirik, Maria Sorokina, Christoph Steinbeck
The generation of constitutional isomer chemical spaces has been a subject of cheminformatics since the early 1960s, with applications in structure elucidation and elsewhere. In order to perform such a generation efficiently, exhaustively and isomorphism-free, the structure generator needs to ensure the building of…
Authors not listed
Active assembly of matter is a defining trait of living systems, enabling the creation of far-from-equilibrium materials essential for the functionality of life. This is achieved through energy-dissipative, multi-step processes facilitated by various biomolecular agents for chemical and mechanical assembly of matter.…
Authors not listed
Genetic Algorithms are a powerful method to solve optimization problems with complex cost functions over vast search spaces that rely in particular on recombining parts of previous solutions. Crossover operators play a crucial role in this context. Here, we describe a large class of these operators designed for…
Benjamin Ries, Richard J Gowers, James RB Eastwood, Irfan Alibay + 4 more
Alchemical free energy campaigns can be planned using graph theory by building up networks that contain nodes representing molecules that are connected by possible transformations as edges. We introduce Konnektor, an open-source Python package, for systematically planning, modifying, and analyzing free energy…
Authors not listed
Water structure is crucially important to protein function and catalysis and can be conserved throughout related proteins despite differences in sequence. The complex hydrogen bonding networks formed by water molecules and protein residues has been studied extensively, with graph theory-based methods frequently used to…
Authors not listed
Three-dimensional (3D) covalent organic frameworks (COFs) with high connectivity provide an intricate yet robust scaffold for precise enzyme immobilization—striking a balance between substrate accessibility and enzyme protection, both critical for efficient biocatalysis. In this work, we investigate the effects of…