28 papers · ranked by Valyu relevance
Antonín Škoch, Barbora Rehák Bučková, Jan Mareš, Jaroslav Tintěra + 5 more
'Pavel Sanda' 'Lucia Jajcay' 'Jiří Horáček' 'Filip Španiel' 'Jaroslav Hlinka'] The human brain represents a complex computational system, the function and structure of which may be measured using various neuroimaging techniques focusing on separate properties of the brain tissue and activity. We capture the…
Oualid Benkarim, Casey Paquola, Bo-yong Park, Jessica Royer + 5 more
Ongoing brain function is largely determined by the underlying wiring of the brain, but the specific rules governing this relationship remain unknown. Emerging literature has suggested that functional interactions between brain regions emerge from the structural connections through mono-as well as polysynaptic…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh‐Haghighi + 1 more
'Christoph Simon'] The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh Haghighi + 2 more
The underlying anatomical structure is fundamental to the study of brain networks, but the role of brainstem from a structural perspective is not very well understood. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical structures including…
Arzu HAS SILEMEK, Haitao Chen, Pascal Sati, Wei Gao
The brain’s white matter connections are thought to provide the structural basis for its functional connections between distant brain regions but how our brain selects the best structural routes for effective functional communications remains poorly understood. In this study, we propose a Unified Structural and…
Javier Palma-Espinosa, Sebastián Orellana Villouta, Carlos Coronel-Oliveros, Jean Paul Maidana + 1 more
The brain’s ability to transition between functional states while maintaining both flexibility and stability is shaped by its structural connectivity. Understanding the relationship between brain structure and neural dynamics is a central challenge in neuroscience. Prior studies link neural dynamics to local noisy…
Danilo Benozzo, Giorgia Baron, Ludovico Coletta, Alessandro Chiuso + 2 more
How the emergent functional connectivity (FC) relates to the underlying anatomy (structural connectivity, SC) is one of the biggest questions of modern neuroscience. At the macro-scale level, no one-to-one correspondence between structural and functional links seems to exist. And we posit that to better understand…
Salma Salhi, Youssef Kora, Gisu Ham, Hadi Zadeh Haghighi + 1 more
The underlying anatomical structure is fundamental to the study of brain networks and is likely to play a key role in the generation of conscious experience. We conduct a computational and graph-theoretical study of the human structural connectome incorporating a variety of subcortical structures including the…
Selena Wang, Yi‐Ting Wang, Frederick H. Xu, Li Shen + 1 more
Brain structural connectivity, capturing the white matter fiber tracts among brain regions inferred by diffusion MRI (dMRI), provides a unique characterization of brain anatomical organization. One fundamental question to address with structural connectivity is how to properly summarize and perform statistical…
Peiyu Chen, Hang Yang, Xin Zheng, Hai Jia + 7 more
The human cerebral cortex is organized into functionally segregated but synchronized regions bridged by the structural connectivity of white matter pathways. While structure-function coupling has been implicated in cognitive development and neuropsychiatric disorders, it remains unclear to what extent the…
Chirag Jain, Sravanthi Upadrasta Naga Sita, Avinash Sharma, Bapi Raju Surampudi
The intricate link between brain functional connectivity (FC) and structural connectivity (SC) is explored through models performing diffusion on SC to derive FC, using varied methodologies from single to multiple graph diffusion kernels. However, existing studies have not correlated diffusion scales with specific…
Zhen-Qi Liu, Bertha Vázquez-Rodríguez, R. Nathan Spreng, Boris C. Bernhardt + 2 more
The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally…
Ittai Shamir, Yaniv Assaf
Despite great progress in uncovering the complex connectivity patterns of the human brain over the last two decades, the field of connectomics still experiences a bias in its viewpoint of the cerebral cortex. Due to a lack of information regarding exact end points of fiber tracts inside cortical gray matter, the cortex…
Viljami Sairanen
Combining the functional and structural connectomes of the human brain on macro-scale could provide information on various brain diseases and conditions. Unfortunately, accomplishing such combination is not trivial as the connectomes are usually derived from different imaging and measuring modalities that are based on…
Jui-To Wang, Ching-Po Lin, Huei-Min Liu, Carlo Pierpaoli + 1 more
Traditional brain connectivity studies have focused mainly on structural connectivity, often relying on tractography with diffusion MRI (dMRI) to reconstruct white matter pathways. In parallel, studies of functional connectivity have examined correlations in brain activity using fMRI. However, emerging methodologies…
Vanessa Cool, Niels Aage, Ole Sigmund
Topology optimization facilitates the automated design of high-performance structures across various engineering fields but, if unconstrained, often produces designs that are complex and difficult to manufacture. A key attribute of the resulting designs is connectivity, which involves controlling the presence of solid…
Aura Reggiani
This paper highlights the relevance of connectivity and its architecture as a general conceptual framework which underlies and integrates the concepts of network vulnerability, complexity, and resilience. In particular, it will be pointed out that connectivity architecture can be considered an explicit key element for…
Oriol Artime, Marco Grassia, Manlio De Domenico, James P. Gleeson + 4 more
Complex networks are ubiquitous: a cell, the human brain, a group of people and the Internet are all examples of interconnected manybody systems characterized by macroscopic properties that cannot be trivially deduced from those of their microscopic constituents. Such systems are exposed to both internal, localized…
Tong Lu, Yuan Zhang, Peter Kochunov, Elliot Hong + 1 more
Brain connectome analysis commonly compresses high-resolution brain scans (typically composed of millions of voxels) down to only hundreds of regions of interest (ROIs) by averaging within-ROI signals. This huge dimension reduction improves computational speed and the morphological properties of anatomical structures…
Arsham Ghavasieh, Giulia Bertagnolli, Manlio De Domenico
Microscopic structural damage, such as lesions in neural systems or disruptions in urban transportation networks, can impair the dynamics crucial for systems' functionality, such as electrochemical signals or human flows, or any other type of information exchange, respectively, at larger topological scales. Damage is…
David Papo, Javier M. Buldú
Representing the brain as a complex network typically involves approximations of both biological detail and network structure. Here, we discuss the sort of biological detail that may improve network models of brain activity and, conversely, how standard network structure may be refined to more directly address…
Luka Blagojević, Márton Pósfai
Data describing the three-dimensional structure of physical networks is increasingly available, leading to a surge of interest in network science to explore the relationship between the shape and connectivity of physical networks. We contribute to this effort by standardizing and analyzing 15 data sets from different…
Authors not listed
Active assembly of matter is a defining trait of living systems, enabling the creation of far-from-equilibrium materials essential for the functionality of life. This is achieved through energy-dissipative, multi-step processes facilitated by various biomolecular agents for chemical and mechanical assembly of matter.…
Authors not listed
Genetic Algorithms are a powerful method to solve optimization problems with complex cost functions over vast search spaces that rely in particular on recombining parts of previous solutions. Crossover operators play a crucial role in this context. Here, we describe a large class of these operators designed for…
Benjamin Ries, Richard J Gowers, James RB Eastwood, Irfan Alibay + 4 more
Alchemical free energy campaigns can be planned using graph theory by building up networks that contain nodes representing molecules that are connected by possible transformations as edges. We introduce Konnektor, an open-source Python package, for systematically planning, modifying, and analyzing free energy…
Authors not listed
Water structure is crucially important to protein function and catalysis and can be conserved throughout related proteins despite differences in sequence. The complex hydrogen bonding networks formed by water molecules and protein residues has been studied extensively, with graph theory-based methods frequently used to…
Authors not listed
Three-dimensional (3D) covalent organic frameworks (COFs) with high connectivity provide an intricate yet robust scaffold for precise enzyme immobilization—striking a balance between substrate accessibility and enzyme protection, both critical for efficient biocatalysis. In this work, we investigate the effects of…
Richard Apodaca
Despite its widespread use, Simplified Molecular Input Line Entry System (SMILES) remains underspecified. The lack of a detailed specification encourages improvisation by software developers, complicates data standardization efforts, and undermines extension development. Balsa, a reformulation of SMILES, addresses…