21 papers · ranked by Valyu relevance
Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen + 5 more
'Harry Dolstra' 'Rob J. de Boer' 'Carl G. Figdor' 'Johannes Textor' 'Peter Friedl'] Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a…
Antonio Bevilacqua, Leonardo Petruzzi, Barbara Speranza, Daniela Campaniello + 4 more
Alicyclobacillus acidoterrestris is a spoiling microorganism regarded as one of the most important causes of spoilage of fruit juices and acidic products. In this paper, four strains of A. acidoterrestris (type strain-DSM 3922; two wild strains isolated from soil-C8 and C24; wild strain isolated from a spoiled pear…
Francisco D. C. Guerra Liberal, Shannon J. Thompson, Kevin M. Prise, Stephen J. McMahon
'Stephen J. McMahon'] There is agreement that high-LET radiation has a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it interacts with radiations of different qualities, such as X-rays, is less clear. We sought to clarify these effects by quantifying and modelling responses…
Adriana M. De Mendoza, Soňa Michlíková, Steffen Lange, Paula S. Castro + 3 more
'Paula S. Castro' 'Anni G. Muñoz' 'Lisa Eckhardt' 'Leoni A. Kunz‐Schughart'] Mathematical modeling can offer valuable insights into the behavior of biological systems upon treatment. Different mathematical models (empirical, semi-empirical, and mechanistic) have been designed to predict the efficacy of either…
Laura Espina, Diego García-Gonzalo, Rafael Pagán
In food preservation, the synergistic combination of different technologies aims to maximize the total lethality of the process and minimize the intensity of each hurdle. This is especially the case when at least one of the treatments can cause sublethal (reparable) injury in a great proportion of the population, so…
Anita Sapoznikov, Yentl Evgy, Amir Ben-Shmuel, Arieh Schwartz + 5 more
'Ron Alcalay' 'Moshe Aftalion' 'Alon Ben David' 'Noam Erez' 'Reut Falach'] Ricin, an extremely potent toxin produced from the seeds of castor plant, Ricinus communis, is ribosome-inactivating protein that blocks cell-protein synthesis. It is considered a biological threat due to worldwide availability of castor beans…
Sonwabile Arthur Ngcezu, Hans Rabus
This work aims at elaborating the basic assumptions behind the "track-event theory" (TET) and its derivate "radiation action model based on nanodosimetry" (RAMN) by clearly distinguishing between effects of tracks at the cellular level and the induction of lesions in subcellular targets. It is demonstrated that the…
Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen + 5 more
Cytotoxic T lymphocytes (CTL) eliminate tumor target cells in an antigen and cell-contact dependent manner. Lethal hit delivery occurs as a rapid and binary, “yes/no” process when immunogenicity is very high^1–3^, however in vivo CTL often fail to kill solid tumor cells during 1:1 conjugations^4–6^. Using long-term…
Patrick Ofori Tawiah, Luca Finn Gaessler, Greg M. Anderson, Emmanuel Parkay Oladokun + 1 more
Amplified by the decline in antibiotic discovery, the rise of antibiotic resistance has become a significant global challenge in infectious disease control. Extraintestinal Escherichia coli (ExPEC), known to be the most common instigators of urinary tract infections (UTIs), represent such global threat. Novel…
Authors not listed
Metal–organic frameworks (MOFs) are entering water technologies on the premise that abiotic stability predicts ecological safety. We overturn this assumption by showing that UiO-66—often regarded as chemically and structurally robust- remains intact after 7-day ageing in natural borehole water yet undergoes rapid…
Francesco Cordoni, Marta Missiaggia, A. Attili, Scott M. Welford + 2 more
'Emanuele Scifoni' 'Chiara La Tessa'] The present work introduces a rigorous stochastic model, named Generalized Stochastic Microdosimetric Model (GSM2 ), to describe biological damage induced by ionizing radiation. Starting from microdosimetric spectra of energy deposition in tissue, we derive a master equation…
Sebastian D’Amario, Blaire Magee, Allen A. Champagne, Madison E. Wilson + 3 more
To determine whether repetitive subconcussive impacts in collegiate football are associated with altered white matter microstructure, motor control deficits, and changes in concussion symptoms across a single season. Cohort study with non-contact controls and stratification of contact athletes by head-impact exposure.…
Andrew P. Lavender, Ryusuke Takechi, Keisuke Kawata, Kerry Peek + 1 more
'Thomas George Di Virgilio'] In recent decades, repeated minor head impacts resulting in mild traumatic brain injury (mTBI) or sub-concussion due to its cumulative nature, has attracted attention from clinicians and scientists. Sub-concussive head impacts are common and can arise from participation in popular sports…
Angela M. Boutté, Bharani Thangavelu, John Anagli
Concussion, often referred to as mild traumatic brain injury (mTBI), is a bump or blow to the head that causes damage to the brain. An invisible wound is often not observed ([https://www.cdc.gov/headsup/basics/concussion_whatis.html]()) (1). Concussed patients may experience loss of consciousness, dizziness, headaches…
Sebastian D’Amario, Blaire Magee, Allen A. Champagne, Madison E. Wilson + 3 more
Repetitive subconcussive impacts are a growing concern in contact sports due to their potential cumulative effects on brain structure, despite the absence of overt clinical symptoms. In this study, we investigated the effect of repeated subconcussive impact (RSCI) exposure on white matter (WM) microstructure in…
Authors not listed
To understand fracture behaviour in battery materials, X-ray computed tomography (X-ray CT) has become the primary technique for non-destructive particle analysis. Cracking causes performance decline in polycrystalline NMC811 by exposing new surfaces for parasitic electrolyte reactions and disconnecting active material…
Matthew H. J. Bailey, Mark Wilson
Networks of biopolymers occur often in nature, and are vulnerable to damage over time. In this work, a coarse grained model of collagen IV molecules is applied in a 2D hexagonal network and the mechanisms by which these networks can rupture are explored. The networks are stretched linearly in order to study their…
Karla M. Ramos-Torres, Kazue Takahashi, Kryslaine L. Radomski, Emiri T. Mandeville + 5 more
Traumatic brain injury (TBI) can lead to secondary injury, including axon and myelin damage, which contributes to long-term neurological deficits. The PET tracer [^18^F]3F4AP, a fluorinated derivative of the FDA-approved drug 4-aminopyridine, selectively binds to voltage-gated potassium (K_V_) channels, offering a…
Yi Li, Rebecca A. Frederick, Daniel George, Stuart F. Cogan + 3 more
The safe delivery of electrical current to neural tissue depends on many factors, yet previous methods for predicting tissue damage rely on only a few stimulation parameters. Here, we report the development of a machine learning approach that could lead to a more reliable method for predicting electrical…
Ehigbai Oikeh, Jesse Ziebarth, Daniel Kirchhoff, Yongmei Wang + 1 more
In nature, DNA exists primarily in a highly compacted form. The compaction of DNA in vivo is mediated by cationic proteins; histone in somatic nuclei and protamines in sperm chromatin. The extreme, near-crystalline packaging of DNA by protamines in spermatozoa is thought essential for both efficient genetic delivery as…
Abdelrahman Zayed, Yasser Iturria‐Medina, Arno Villringer, Bernhard Sehm + 1 more
'Bernhard Sehm' 'Christopher J. Steele'] Abstract— With an estimated five million new stroke survivors every year and a rapidly aging population suffering from hyperintensities and diseases of presumed vascular origin that affect white matter and contribute to cognitive decline, it is critical that we understand the…