24 papers · ranked by Valyu relevance
Peter Verstraelen, Michiel Van Dyck, Marlies Verschuuren, Nachiket D. Kashikar + 3 more
'Nachiket D. Kashikar' 'Rony Nuydens' 'Jean-Pierre Timmermans' 'Winnok H. De Vos'] Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic connectivity. In dementia, synapse dysfunction…
Justin T. Savage, Juan Ramirez, W. Christopher Risher, Dolores Irala + 1 more
The formation of precise numbers of neuronal connections, known as synapses, is crucial for brain function. Therefore, synaptogenesis mechanisms have been one of the main focuses of cellular and molecular neuroscience. Immunohistochemistry is a common tool for labeling and visualization of synapses. Thus, quantifying…
Yoav Printz, Pritish Patil, Mathias Mahn, Asaf Benjamin + 4 more
The medial prefrontal cortex (mPFC) mediates a variety of complex cognitive functions via its vast and diverse connections with cortical and subcortical structures. Understanding the patterns of synaptic connectivity that comprise the mPFC local network is crucial for deciphering how this circuit processes information…
Huisheng Liu, Edwin R. Chapman, Camin Dean, Anna Dunaevsky
Autapses are connections between a neuron and itself. These connections are morphologically similar to “normal” synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission. However, this has not been directly tested. Here, using a micro-island culture assay in…
Robert Layous, Bálint Tamás, Arpad Mike, Eszter Sipos + 6 more
The hippocampal CA3 region is thought to play crucial roles in episodic memory functions because of the extensive recurrent connections between CA3 pyramidal cells (CA3PCs). However, different methods provided contradicting observations about the synaptic connectivity between CA3PCs. Therefore, we estimated the…
Eleni Vasilaki, Michèle Giugliano
Recent evidence in rodent cerebral cortex and olfactory bulb suggests that short-term dynamics of excitatory synaptic transmission is correlated to the occurrence of stereotypical connectivity motifs. In particular, it was observed that neurons with short-term facilitating synapses form predominantly reciprocal…
Ryota Kobayashi, Shigeru Shinomoto
Review Authors: ['Ryota Kobayashi' 'Shigeru Shinomoto'] This article presents a mini-review about the progress in inferring monosynaptic connections from spike trains of multiple neurons over the past twenty years. First, we explain a variety of meanings of "neuronal connectivity" in different research areas of…
Françoise Chanut
Synapses, the connections that link neurons into circuits, can be plastic or stable in the mammalian brain. Right after birth, synapses form and dissolve among nascent neurons at breakneck speed as the animal adapts to its new surroundings. But, over time, while some plasticity remains and allows for learning, most…
Meiyi Zhang, Jinjian Yu, Louis Tao, Yuxiu Shao
Recent breakthroughs in synaptic-resolution network connectomics have revealed that brain circuits feature fine-scale structural connectivity, such as pairs of correlated synaptic couplings known as second-order motifs. Large-scale recordings of neuronal activity in networks containing nonlinear neurons reveal…
Jonathan W. Garcia, Thomas M. Bartol, Terrence J. Sejnowski
Chemical synapses exhibit a diverse array of internal mechanisms that affect the dynamics of transmission efficacy. Many of these processes, such as release of neurotransmitter and vesicle recycling, depend strongly on activity-dependent influx and accumulation of Ca^2+^. To model how each of these processes may affect…
Daniele Poli, Vito P. Pastore, Paolo Massobrio
Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental…
Dasiel O. Borroto-Escuela, Emmanuell Gonzalez-Cristo, Verty Ochoa-Torres, Emilio M. Serra-Rojas + 3 more
'Verty Ochoa-Torres' 'Emilio M. Serra-Rojas' 'Patrizia Ambrogini' 'Luis E. Arroyo-García' 'Kjell Fuxe'] The histochemical Falck-Hillarp method for the localization of dopamine (DA), noradrenaline (NA) and serotonin in the central nervous system (CNS) of rodents was introduced in the 1960s. It supported the existence of…
Johanna Senk, Birgit Kriener, Mikael Djurfeldt, Nicole Voges + 6 more
'Han-Jia Jiang' 'Lisa Schüttler' 'Gabriele Gramelsberger' 'Markus Diesmann' 'Hans Ekkehard Pleßer' 'Sacha J. van Albada'] Sustainable research on computational models of neuronal networks requires published models to be understandable, reproducible, and extendable. Missing details or ambiguities about mathematical…
Felix Z. Hoffmann, Jochen Triesch
Overrepresentation of bidirectional connections in local cortical networks has been repeatedly reported and is in the focus of the ongoing discussion of non-random connectivity. Here we show in a brief mathematical analysis that in a network in which connection probabilities are symmetric in pairs, Pij = Pji, the…
Giuseppe Chindemi, Marwan Abdellah, Oren Amsalem, Ruth Benavides-Piccione + 14 more
Long-term potentiation (LTP) and long-term depression (LTD) of pyramidal cell connections are among the key mechanisms underlying learning and memory in the brain. Despite their important role, only a few of these connections have been characterized in terms of LTP/LTD dynamics, such as the one between layer 5…
Pascale P. Quilichini, Christophe Bernard
Neuronal firing pattern, which includes both the frequency and the timing of action potentials, is a key component of information processing in the brain. Although the relationship between neuronal output (the firing pattern) and function (during a task/behavior) is not fully understood, there is now considerable…
Sebastian Curti, Federico Davoine, Antonella Dapino, Xinbo Li
Simple Summary Relevant brain functions, such as perception, organization of behavior, and cognitive processes, are the outcome of information processing by neural circuits. Within these circuits, communication between neurons mainly relies on two modalities of synaptic transmission: chemical and electrical. Moreover…
Tzitzitlini Alejandre-García, Samuel Kim, Jesús Pérez-Ortega, Rafael Yuste
Neuronal ensembles are coactive groups of cortical neurons, found in both spontaneous and evoked activity, which can mediate perception and behavior (12; 8; 9; 34). To understand the mechanism that lead to the formation of neuronal ensembles, we generated optogenetically artificial photo-ensembles in layer 2/3…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…
Sven Jahnke, Marc Timme, Raoul-Martin Memmesheimer
Sparse random networks contain structures that can be considered as diluted feed-forward networks. Modeling of cortical circuits has shown that feed-forward structures, if strongly pronounced compared to the embedding random network, enable reliable signal transmission by propagating localized (sub-network) synchrony.…
Authors not listed
Membrane fusion underpins many fundamental cellular processes, yet the design of artificial fusogens that can interact with specific cell surface markers in a precise and predictable manner remains a major challenge. Here we demonstrate that cholera toxin B-subunit (CTB), a naturally occurring glycolipid-binding…