20 papers · ranked by Valyu relevance
George Kastellakis, Panayiota Poirazi
In the study of memory engrams, synaptic memory allocation is a newly emerged theme that focuses on how specific synapses are engaged in the storage of a given memory. Cumulating evidence from imaging and molecular experiments indicates that the recruitment of synapses that participate in the encoding and expression of…
Jens P. Weber, Bertalan K. Andrásfalvy, Marina Polito, Ádám Magó + 2 more
'Balázs B. Ujfalussy' 'Judit K. Makara'] Nonlinear interactions between coactive synapses enable neurons to discriminate between spatiotemporal patterns of inputs. Using patterned postsynaptic stimulation by two-photon glutamate uncaging, here we investigate the sensitivity of synaptic Ca2+ signalling and long-term…
Bruce P Graham, Ausra Saudargiene, Stuart Cobb
We use a computational model to investigate the possible cooperativity between coactive synapses, both within and between input pathways, in determining plasticity outcomes at individual synapses on a hippocampal CA1 pyramidal cell (PC). The detailed compartmental model of the PC, based on a reconstructed morphology…
Aseel Shomar, Lukas Geyrhofer, Noam E. Ziv, Naama Brenner + 1 more
'Kim T. Blackwell'] Synapses are dynamic molecular assemblies whose sizes fluctuate significantly over time-scales of hours and days. In the current study, we examined the possibility that the spontaneous microscopic dynamics exhibited by synaptic molecules can explain the macroscopic size fluctuations of individual…
Jan Karbowski, Paulina Urban
We investigate a mutual relationship between information and energy during early phase of LTP induction and maintenance in a large-scale system of mutually coupled dendritic spines with discrete internal states and probabilistic dynamics within the framework of nonequilibrium stochastic thermodynamics. In order to…
Jan Karbowski, Paulina Urban
We investigate a mutual relationship between information and energy during early phase of LTP induction and maintenance in a large-scale system of mutually coupled dendritic spines, with discrete internal states and probabilistic dynamics, within the framework of nonequilibrium stochastic thermodynamics. In order to…
Moritz F. P. Becker, Christian Tetzlaff
The maintenance of synaptic changes resulting from long-term potentiation (LTP) is essential for brain functions. Different LTP phases have been associated with diverse molecular processes and pathways, and the molecular underpinnings of LTP on the time scales of a few minutes or of several hours are well established.…
Victor Matveev, Richard Betram, Arthur Sherman
Interaction between calcium nanodomains of individual voltage-dependent calcium channels in triggering exocytosis in neurons and endocrine cells is of significant importance for understanding localized calcium signaling in general and synaptic physiology in particular. Such channel domain interaction (overlap) is often…
Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson + 10 more
supralinear effects on the vesicle fusion rate Authors: ['Sebastiaan Schotten' 'Marieke Meijer' 'Alexander Matthias Walter' 'Vincent Huson' 'Lauren Mamer' 'Lawrence Kalogreades' 'Mirelle ter Veer' 'Marvin Ruiter' 'Nils Brose' 'Christian Rosenmund' 'Jakob Balslev Sørensen' 'Matthijs Verhage' 'Lennart Niels Cornelisse'…
Moritz Deger, Alexander Seeholzer, Wulfram Gerstner
Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of dendritic spine shape and volume, a correlate of synaptic strength, can be tracked in vivo for weeks. Here, we present a combined model of spike-timing dependent…
Everton J. Agnes, Tim P. Vogels
The brain’s functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity they also affect each other. The nature of such “codependency” is difficult to disentangle experimentally, because multiple synapses must be monitored simultaneously. To help understand the experimentally…
Mariana Nunes, Natália Madeira, Rosalina Fonseca
Synapses change their weights in response to neuronal activity and in turn, neuronal networks alter their response properties and ultimately allow the brain to store information as memories. As for memories, not all events are maintained over time. Maintenance of synaptic plasticity depends on the interplay between…
Anita Mehta
We first review traditional approaches to memory storage and formation, drawing on the literature of quantitative neuroscience as well as statistical physics. These have generally focused on the fast dynamics of neurons; however, there is now an increasing emphasis on the slow dynamics of synapses, whose weight changes…
Authors not listed
Protein-protein interactions (PPIs) play an essential role in biological processes. Molecules that stabilize or induce PPIs in ternary complexes have received growing attention for their therapeutic potential in engaging ’undruggable’ targets and their high selectivity. Here, we investigate the kinetics and thermody-…
Sang-Yoon Kim, Woochang Lim
We consider a two-population network consisting of both inhibitory (I) interneurons and excitatory (E) pyramidal cells. This I-E neuronal network has adaptive dynamic I to E and E to I interpopulation synaptic strengths, governed by interpopulation spike-timing-dependent plasticity (STDP). In previous works without…
Tzitzitlini Alejandre-García, Samuel Kim, Jesús Pérez-Ortega, Rafael Yuste
Neuronal ensembles are coactive groups of cortical neurons, found in both spontaneous and evoked activity, which can mediate perception and behavior (12; 8; 9; 34). To understand the mechanism that lead to the formation of neuronal ensembles, we generated optogenetically artificial photo-ensembles in layer 2/3…
Rafael R. Borges, Fernando S. Borges, Ewandson L. Lameu, Antônio M. Batista + 4 more
'Antônio M. Batista' 'Kelly C. Iarosz' 'Iberê L. Caldas' 'Ricardo L. Viana' 'Miguel A. F. Sanjuán'] In this paper, we study the effects of spike timing-dependent plasticity on synchronisation in a network of Hodgkin-Huxley neurons. Neuron plasticity is a flexible property of a neuron and its network to change…
Stephanie Wankowicz, James Fraser
During protein folding, proteins transition from a disordered polymer into a globular structure, markedly decreasing their conformational degrees of freedom and consequently leading to a substantial reduction in entropy. Nonetheless, folded proteins still retain significant entropy as they fluctuate between the…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…