27 papers · ranked by Valyu relevance
Yuichi Katori, Kazuhiro Sakamoto, Hajime Mushiake, Kazuyuki Aihara
Synaptic transmission efficacy transiently changes in a short period of time with generation of presynaptic spikes. Depending on changes in releasable neurotransmitters and calcium concentration in presynaptic terminals, the transmission efficacy of the dynamic synapses decreases (short-term depression) or increases…
Bin Wang, Olga K. Dudko
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters into the synaptic cleft within just milliseconds of the action potential. Yet neurotransmitter release lacks a theoretical framework that is both phenomenologically accurate and…
Srdjan Ostojic, Stefano Fusi
Often we need to perform tasks in an environment that changes stochastically. In these situations it is important to learn the statistics of sequences of events in order to predict the future and the outcome of our actions. The statistical description of many of these sequences can be reduced to the set of…
Abed Ghanbari, Naixin Ren, Christian Keine, Carl Stoelzel + 3 more
Information transmission in neural networks is influenced by both short-term synaptic plasticity (STP) as well as non-synaptic factors, such as after-hyperpolarization currents and changes in excitability. Although these effects have been widely characterized in vitro using intracellular recordings, how they interact…
Vladislav Volman, Herbert Levine, Terrence J. Sejnowski, Lyle J. Graham
'Lyle J. Graham'] The sensitivity of a neuron to its input can be modulated in several ways. Changes in the slope of the neuronal input-output curve depend on factors such as shunting inhibition, background noise, frequency-dependent synaptic excitation, and balanced excitation and inhibition. However, in early…
Bin Wang, Olga K Dudko, Timothy E Behrens, Timothy E Behrens
Rapid and precise neuronal communication is enabled through a highly synchronous release of signaling molecules neurotransmitters within just milliseconds of the action potential. Yet neurotransmitter release lacks a theoretical framework that is both phenomenologically accurate and mechanistically realistic. Here, we…
Tjeerd V. olde Scheper, Rhiannon M. Meredith, Huibert D. Mansvelder, Jaap van Pelt + 1 more
'Jaap van Pelt' 'Arjen van Ooyen'] Spike Timing-Dependent Plasticity has been found to assume many different forms. The classic STDP curve, with one potentiating and one depressing window, is only one of many possible curves that describe synaptic learning using the STDP mechanism. It has been shown experimentally that…
Rui Ponte Costa, Beatriz E.P. Mizusaki, P. Jesper Sjöström, Mark C. W. van Rossum
Experimental evidence has shown that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we discuss some of the functional consequences of this diversity in expression loci. In particular, using a biologically tuned model of…
Ranjita Dutta Roy, Melanie I. Stefan, Christian Rosenmund
Hippocampal neurons show different types of short-term plasticity (STP). Some exhibit facilitation of their synaptic responses and others depression. In this review we discuss presynaptic biophysical properties behind heterogeneity in STP in hippocampal neurons such as alterations in vesicle priming and docking…
Ewandson L. Lameu, Elbert E. N. Macau, Fernando S. Borges, Kelly C. Iarosz + 5 more
'Kelly C. Iarosz' 'Iberê L. Caldas' 'Rafael R. Borges' 'Paulo R. Protachevicz' 'Ricardo L. Viana' 'Antônio M. Batista'] Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on…
Attila Szücs, Fulvia Berton, Thomas Nowotny, Pietro Sanna + 2 more
'Walter Francesconi' 'Vladimir Brezina'] Neurons display a high degree of variability and diversity in the expression and regulation of their voltage-dependent ionic channels. Under low level of synaptic background a number of physiologically distinct cell types can be identified in most brain areas that display…
Chelsy R. Eddings, Shigeki Watanabe
Neural circuitry depends on excitatory and inhibitory regulation of activity to yield functional outputs. However, examinations of synaptic vesicle recycling have focused heavily on excitatory synapses, leaving many questions unanswered for inhibitory synapse dynamics. Here we show that both excitatory and inhibitory…
Stefano Fusi
Memory is often defined as the mental capacity of retaining information about facts, events, procedures and more generally about any type of previous experience. Memories are remembered as long as they influence our thoughts, feelings, and behavior at the present time. Memory is also one of the fundamental components…
Stefano Fusi
Memory is a complex phenomenon that involves several distinct mechanisms. These mechanisms operate at different spatial and temporal levels. This chapter focuses on the theoretical framework and the mathematical models that have been developed to understand how these mechanisms are orchestrated to store, preserve and…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…
Grit Bornschein, Simone Brachtendorf, Abdelmoneim Eshra, Robert Kraft + 3 more
Synaptotagmin 1 (Syt1) and Syt2 are the main Ca^2+^ sensors triggering synchronous release in the brain. The Ca^2+^-sensitivity of Syt2-triggered release has been studied in detail. However, for Syt1, the dominating isoform in the neocortex, quantitative detail is lacking. We measured the Ca^2+^-dependency of…
Cian O’Donnell
Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1—100 ms) and organism behaviour during learning (seconds—minutes). What mechanisms bridge this timescale gap? What are the…
Felicitas Bruentgens, Laura Moreno Velasquez, Alexander Stumpf, Daniel Parthier + 5 more
Synapsins are highly abundant presynaptic proteins that play a crucial role in neurotransmission and plasticity via the clustering of synaptic vesicles. The synapsin III isoform is usually downregulated after development, but in hippocampal mossy fiber boutons it persists in adulthood. Mossy fiber boutons express…
Thi Kim Thoa Thieu, Roderick Melnik
> Abstract. Working memory (WM) has been intensively used to enable the temporary storing of information for processing purposes, playing an important role in the execution of various cognitive tasks. Recent studies have shown that information in WM is not only maintained through persistent recurrent activity but also…
Yoichi Araki, Kacey E. Rajkovich, Elizabeth E. Gerber, Timothy R. Gamache + 6 more
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in SYNGAP1 in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous Syngap1 knockout mice display deficits in synaptic plasticity, learning…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…
James H. Scully, Jassem Bourahmah, David E. Bloom, Andrey Shilnikov
The purpose of this paper is trifold – to serve as an instructive resource and a reference catalog for biologically plausible modeling with i) conductance-based models, coupled with ii) strength-varying slow synapse models, culminating in iii) two canonical pair-wise rhythm-generating networks. We document the…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
Farzaneh Asadpour, Xinwei Zhang, Mohammad Mazloum-Ardakani, Maysam Mirzaei + 2 more
We used liposomes loaded with different monoamines, dopamine (DA) and serotonin (5-HT), to simulate vesicular release and to monitor the dynamics of chemical release from isolated vesicles during vesicle impact electrochemical cytometry (VIEC). The release of DA from liposomes presents a longer release time compared to…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…